Occurrence and toxicity of a fusarium mycotoxin, zearalenone

Rai, Ankita; Das, Mukul; Tripathi, Anurag

doi:10.1080/10408398.2019.1655388

Cited by 241 publications

(157 citation statements)

References 198 publications

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“…In animals, including mice, pigs and cattle, ZEA can damage the reproductive organs and cause reproductive disorders [113,114]. Toxicokinetic studies prove that ZEA is absorbed in the digestive tract, and then metabolized and distributed to various parts of the body [120]. Zearalenone is a competitive substrate for enzymes involved in the synthesis and metabolism of steroids, and therefore can potentially act as a factor disturbing hormonal balance [121].…”

Section: Zearalenonementioning

confidence: 99%

Fusarium Head Blight, Mycotoxins and Strategies for Their Reduction

2020

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Mycotoxins are secondary metabolites of microscopic fungi, which commonly contaminate cereal grains. Contamination of small-grain cereals and maize with toxic metabolites of fungi, both pathogenic and saprotrophic, is one of the particularly important problems in global agriculture. Fusarium species are among the dangerous cereal pathogens with a high toxicity potential. Secondary metabolites of these fungi, such as deoxynivalenol, zearalenone and fumonisin B1 are among five most important mycotoxins on a European and world scale. The use of various methods to limit the development of Fusarium cereal head diseases and grain contamination with mycotoxins, before and after harvest, is an important element of sustainable agriculture and production of safe food. The applied strategies utilize chemical and non-chemical methods, including agronomic, physical and biological treatments. Biological methods now occupy a special place in plant protection as an element of biocontrol of fungal pathogens by inhibiting their development and reducing mycotoxins in grain. According to the literature, Good Agricultural Practices are the best line of defense for controlling Fusarium toxin contamination of cereal and maize grains. However, fluctuations in weather conditions can significantly reduce the effectiveness of plants protection methods against infection with Fusarium spp. and grain accumulation of mycotoxins.

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Section: Zearalenonementioning

confidence: 99%

Fusarium Head Blight, Mycotoxins and Strategies for Their Reduction

2020

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“…most important agro-economic and public health classes of mycotoxins are aflatoxins, ochratoxin A (OTA), zearalenone (ZEA), trichothecenes (TCTs), fumonisins (FUMs), patulin (PT), Alternaria toxins and ergot toxins. They are produced by species of Fusarium, Penicillium, Aspergillus, Claviceps and Alternaria (Liew and Mohd-Redzwan, 2018;Rai et al, 2019). Some of them can produce more than one mycotoxin, and some mycotoxins are produced by more than one fungal species (Marin et al, 2013) ( Table 1).…”

Section: Most Susceptible Cropsmentioning

confidence: 99%

“…Zearalenone (ZEA) is one of the most prevalent nonsteroidal oestrogenic mycotoxins produced by Fusarium genera such as Fusarium graminearum, Fusarium culmorum, Fusarium crookwellense, Fusarium semitectum and Fusarium equiseti, which are distributed worldwide (Rai et al, 2019). ZEA and its major alcohol metabolites, α-zearalenol (α-ZOL), β-zearalenol (β-ZOL), α-zearalanol (α-ZAL, zeranol) and β-zearalanol (β-ZAL, tarelanol) share structural similarity with the sex hormone, 17β-estradiol, and can be found naturally or as result of metabolism of humans and animals (Danicke, 2015).…”

Section: Zearalenonementioning

confidence: 99%

Current Status of Mycotoxin Contamination of Food and Feeds and Associated Public Health Risk in Serbia

Milićević¹,

Udovički²,

Petrović³

et al. 2020

Meat Technology

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Mycotoxins are chemical hazards of microbiological origin, produced mainly by filamentous fungi during their secondary metabolism. The role of mycotoxins has been recognized in the aetiology of a number of diseases, particularly cancers that belong to non-communicable diseases (NCDs). The NCDs have a leading and growing contribution to preventable deaths and disability across the globe. The NCDs are known as chronic diseases, tend to be of long duration and are the result of a combination of genetic, physiological, environmental and behavioural factors. Following the increased interest in health effects caused by synergisms between natural and synthetic contaminants along the food chain, mycotoxin contamination will continue to be an area of concern for producers, manufacturers, regulatory agencies, researchers and consumers in the future. Considering that their presence in food depends strongly on climatic conditions, in Serbia, recent drought and then flooding confirmed that mycotoxins are one of the foodborne hazards most susceptible to climate change. In this article, we review key aspects of mycotoxin contamination of the food supply chain and attempt to highlight the latest trends and projections for mycotoxin reduction from a Serbian perspective.

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“…It appears as a contaminant in crops, cereal-based products (e.g., flour, bakery goods, and beer), and in other commodities (Rogowska et al 2019). Despite its nonsteroidal structure, ZEN can bind to estrogen receptors (Loi et al 2017;Shier et al 2001) causing reproductive disorders, as well as its potential genotoxic, hepatotoxic, teratogenic, and immunotoxic effects are also suggested (Rai et al 2019;Rogowska et al 2019). The involvement of ZEN in the development of breast and esophageal cancers has been emerged; however, ZEN is classified as a group 3 carcinogen by the IARC (Rai et al 2019).…”

Section: Introductionmentioning

confidence: 99%

“…ZEN is extensively biotransformed in mammals (Rai et al 2019). Its reduction by hydroxysteroid dehydrogenases leads to the formation of αand β-zearalenols (α-and β-ZELs), zearalanone (ZAN, Fig.…”

Section: Introductionmentioning

confidence: 99%

Interactions of zearalanone, α-zearalanol, β-zearalanol, zearalenone-14-sulfate, and zearalenone-14-glucoside with serum albumin

et al. 2020

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The xenoestrogenic mycotoxin zearalenone is a Fusarium-derived food and feed contaminant. In mammals, the reduced (e.g., zearalanone, α-zearalanol, and β-zearalanol) and conjugated (e.g., zearalenone-14-sulfate) metabolites of zearalenone are formed. Furthermore, filamentous fungi and plants are also able to convert zearalenone to conjugated derivatives, including zearalenone-14-sulfate and zearalenone-14-glucoside, respectively. Serum albumin is the dominant plasma protein in the circulation; it interacts with certain mycotoxins, affecting their toxicokinetics. In a previous investigation, we demonstrated the remarkable species differences regarding the albumin binding of zearalenone and zearalenols. In the current study, the interactions of zearalanone, α-zearalanol, β-zearalanol, zearalenone-14-sulfate, and zearalenone-14-glucoside with human, bovine, porcine, and rat serum albumins were examined, employing fluorescence spectroscopy and affinity chromatography. Zearalanone, zearalanols, and zearalenone-14-sulfate form stable complexes with albumins tested (K = 9.3 × 103 to 8.5 × 105 L/mol), while the albumin binding of zearalenone-14-glucoside seems to be weak. Zearalenone-14-sulfate formed the most stable complexes with albumins examined. Considerable species differences were observed in the albumin binding of zearalenone metabolites, which may have a role in the interspecies differences regarding the toxicity of zearalenone.

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Occurrence and toxicity of a fusarium mycotoxin, zearalenone

Cited by 241 publications

References 198 publications

Fusarium Head Blight, Mycotoxins and Strategies for Their Reduction

Fusarium Head Blight, Mycotoxins and Strategies for Their Reduction

Current Status of Mycotoxin Contamination of Food and Feeds and Associated Public Health Risk in Serbia

Interactions of zearalanone, α-zearalanol, β-zearalanol, zearalenone-14-sulfate, and zearalenone-14-glucoside with serum albumin

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