Occurrence and transfer of a cyanobacterial neurotoxin β-methylamino-l-alanine within the aquatic food webs of Gonghu Bay (Lake Taihu, China) to evaluate the potential human health risk

Jiao, Yiying; Chen, Qiankun; Chen, Xu; Wang, Xin; Liao, Xuewei; Jiang, Lijuan; Wu, Jun; Yang, Liuyan

doi:10.1016/j.scitotenv.2013.08.064

Cited by 81 publications

(61 citation statements)

References 34 publications

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“…Bioaccumulation is evident in the food web as organisms at higher trophic levels have been reported to contain greater concentrations of BMAA. Jiao et al (2014) found greater BMAA concentrations in fish muscle tissue than in invertebrates, particularly during times of cyanobacterial bloom outbreak and decline. Furthermore during bloom decline fish muscle contained higher BMAA levels than the cyanobacteria.…”

Section: Introductionmentioning

confidence: 84%

“…Therefore free BMAA increased with bloom decline. Jiao et al (2014) sampled cyanobacterial blooms three times during the season in eutrophic Lake Taihu, China, and reported that total (free and protein-associated) BMAA concentrations in cyanobacterial fractions were higher during bloom outbreak and decline than during bloom emergence. These authors suggested that Microcystis spp.…”

Section: Discussionmentioning

confidence: 99%

“…5, No. 1; flagelliforme) (Jiao et al, 2014). When livestock drink water from farm dugouts or ditches containing algal blooms, a possible risk of tainted meat and milk may ensue, and BMAA may promote chronic animal intoxication (Metcalf et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

“…BMAA has been found in every aquatic trophic level in ecosystems affected by cyanobacterial blooms (Jiao et al, 2014). Submerged macrophytes such as Myriophyllum and Ceratophyllum may assimilate BMAA by direct absorption (Al-Sammak, Hoagland, Cassada, & Snow, 2014), and BMAA may also be produced by algal epiphytes on plant surfaces.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore during bloom decline fish muscle contained higher BMAA levels than the cyanobacteria. In fish this toxin increases with age (Lage et al, 2015), and carnivorous, filter-feeding and some omnivorous species are associated with the greatest biomagnifications, as are bottom feeding species (Jiao et al, 2014). A number of workers (Caller et al,2009(Caller et al, , 2012Bradley et al, 2013) have reviewed the putative links between regions subject to cyanobacterial blooms, for example proximity to lakes, agricultural lagoons or consumption of local fish, and clusters of ALS occurrence in the human population.…”

Section: Introductionmentioning

confidence: 99%

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Seasonal Nearshore Occurrence of the Neurotoxin β N methylamino L alanine (BMAA) in Lake Winnipeg, Canada

Pip¹,

Munford²,

Bowman³

2016

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Seasonal fluctuation patterns of the neurotoxic amino acid β-N-methylamino-L-alanine (BMAA) were examined at four-day intervals during the ice-free season in water at three nearshore stations in the south basin of Lake Winnipeg, Canada. BMAA patterns were significantly exponentially correlated with concurrent phaeophytin, and inversely with chlorophyll a, indicating that free BMAA concentrations increased as blooms declined. BMAA was also significantly related to preceding microcystin concentrations, and as chlorophyll a declined, the proportion of BMAA relative to microcystin increased. Cross correlations identified significant relationships between BMAA and immediately preceding nitrate-N/inorganic phosphorus ratios, nitrate-N, rainfall, and a marginal inverse correlation with inorganic phosphorus. Total suspended solids levels were also significantly associated with BMAA, likely due to shading effects. A very high BMAA concentration was found under collapse of intense bloom conditions. These results have implications for water quality monitoring, nutrient management strategies and public health.

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Section: Introductionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Seasonal Nearshore Occurrence of the Neurotoxin β N methylamino L alanine (BMAA) in Lake Winnipeg, Canada

Pip¹,

Munford²,

Bowman³

2016

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Extraction and Quantification of BMAA from Water Samples

Bruno,

Messineo

2023

Protocols for Cyanobacteria Sampling and Detection of Cyanotoxin

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Cyanotoxins: producing organisms, occurrence, toxicity, mechanism of action and human health toxicological risk evaluation

et al. 2017

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Cyanobacteria were present on the earth 3.5 billion years ago; since then they have colonized almost all terrestrial and aquatic ecosystems. They produce a high number of bioactive molecules, among which some are cyanotoxins. Cyanobacterial growth at high densities, forming blooms, is increasing in extension and frequency, following anthropogenic activities and climate changes, giving rise to some concern for human health and animal life exposed to cyanotoxins. Numerous cases of lethal poisonings have been associated with cyanotoxins ingestion in wild animal and livestock. In humans few episodes of lethal or severe human poisonings have been recorded after acute or short-term exposure, but the repeated/chronic exposure to low cyanotoxin levels remains a critical issue. The properties of the most frequently detected cyanotoxins (namely, microcystins, nodularins, cylindrospermopsin and neurotoxins) are here critically reviewed, describing for each toxin the available information on producing organisms, biosynthesis/genetic and occurrence, with a focus on the toxicological profile (including kinetics, acute systemic toxicity, mechanism and mode of action, local effects, repeated toxicity, genotoxicity, carcinogenicity, reproductive toxicity; human health effects and epidemiological studies; animal poisoning) with the derivation of health-based values and considerations on the risks for human health.

show abstract

Occurrence and transfer of a cyanobacterial neurotoxin β-methylamino-l-alanine within the aquatic food webs of Gonghu Bay (Lake Taihu, China) to evaluate the potential human health risk

Cited by 81 publications

References 34 publications

Seasonal Nearshore Occurrence of the Neurotoxin β N methylamino L alanine (BMAA) in Lake Winnipeg, Canada

Seasonal Nearshore Occurrence of the Neurotoxin β N methylamino L alanine (BMAA) in Lake Winnipeg, Canada

Extraction and Quantification of BMAA from Water Samples

Cyanotoxins: producing organisms, occurrence, toxicity, mechanism of action and human health toxicological risk evaluation

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