Occurrence, Distribution, and Characteristics of Boscalid-Resistant <i>Corynespora cassiicola</i> in China

Zhu, Fadi; Shi, Yanxia; Xie, Xuewen; Chai, Ali; Li, Baoju

doi:10.1094/pdis-11-17-1760-re

Cited by 37 publications

(40 citation statements)

References 23 publications

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“…Resistance to boscalid was found in cucumber C. cassiicola isolates in Japan (Miyamoto et al, 2009(Miyamoto et al, , 2010. HNS or resistant C. cassiicola isolates from Soya bean were reported in Brazil to fluxapyroxad and boscalid fungicides (Teramoto et al, 2017); and in China, the resistance of C. cassiicola isolates from cucumber to boscalid is widespread (Zhu et al, 2019).…”

Section: Benzimidazoles and Thiophanates Are Among Methyl Benzimidazolementioning

confidence: 99%

“…The use of SDHI fungicides to manage C. cassiicola on cucumber was discouraged in certain areas of the country to avoid the emergence of multi-resistance (Miyamoto et al, 2010;Zhu et al, 2019).…”

Section: Benzimidazoles and Thiophanates Are Among Methyl Benzimidazolementioning

confidence: 99%

“…Resistance to boscalid was found in cucumber C. cassiicola isolates in Japan (Miyamoto et al., 2009, 2010). HNS or resistant C. cassiicola isolates from Soya bean were reported in Brazil to fluxapyroxad and boscalid fungicides (Teramoto et al., 2017); and in China, the resistance of C. cassiicola isolates from cucumber to boscalid is widespread (Zhu et al., 2019). The use of SDHI fungicides to manage C. cassiicola on cucumber was discouraged in certain areas of the country to avoid the emergence of multi‐resistance (Miyamoto et al., 2010; Zhu et al., 2019).…”

Section: Introductionmentioning

confidence: 99%

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The fungal pathogen Corynespora cassiicola: A review and insights for target spot management on cotton and Soya bean

Rondon

Lawrence

2021

Journal of Phytopathology

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Section: Benzimidazoles and Thiophanates Are Among Methyl Benzimidazolementioning

confidence: 99%

Section: Benzimidazoles and Thiophanates Are Among Methyl Benzimidazolementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The fungal pathogen Corynespora cassiicola: A review and insights for target spot management on cotton and Soya bean

Rondon

Lawrence

2021

Journal of Phytopathology

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“…Most current SDHI compounds have similar structures of amide bridge (Fig. 1(a)), which results in the single binding mode with SDH, 16–20 and consequently causes resistance issues 21,22 . Moreover, the lack of activity against oomycetes led to current bottleneck of SDHI fungicides 15 .…”

Section: Introductionmentioning

confidence: 99%

Design, synthesis and antifungal/anti‐oomycete activity of pyrazolyl oxime ethers as novel potential succinate dehydrogenase inhibitors

Wang

Chen

et al. 2021

Pest Management Science

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BACKGROUND Succinate dehydrogenase inhibitors (SDHIs) play an increasingly important role in controlling plant diseases. However, the similar structures of SDHIs result in rapid development of cross‐resistance development and a clear bottleneck of poor activity against oomycetes, therefore the need to seek new SDHI fungicides with novel structures is urgent. RESULTS Innovative pyrazolyl oxime ethers were designed by replacing amide with oxime ether based on the succinate dehydrogenase (SDH) structure, and 19 pairs of Z‐ and E‐isomers were efficiently prepared for the discovery of SDHI compounds with a novel bridge. Their biological activities against four fungi and two oomycetes were evaluated, and substantial differences were observed between the Z‐ and E‐ isomers of the title compounds. Furthermore, most of these compounds exhibited remarkable activities against Rhizoctonia solani with EC50 values of less than 10 mg L−1 in vitro, and bioassay in vivo further confirmed that E‐I‐6 exhibited good protective efficacy (76.12%) at 200 mg L−1. In addition, Z‐I‐12 provided better activity against the oomycetes Pythium aphanidermatum and Phytophthora capsici (EC50 = 1.56 and 0.93 mg L−1) than those of boscalid. Moreover, E‐I‐12 exhibited excellent SDH inhibition (IC50 = 0.21 mg L−1) thanks to its good binding ability to the SDH by hydrogen‐bonding interactions, π‐cation interaction and hydrophobic interactions. CONCLUSION Novel pyrazolyl oxime ethers have the potential as SDHI compounds for future development, and the strategy of replacing an amide bond with oxime ether may offer an alternative option in SDHI fungicide discovery.

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“…azoxystrobin and pyraclostrobin) (China Pesticide Information Network 2020: http://www.chinapesticide.org.cn/hysj/index.jhtml). Because of the extensive and repeated application of these fungicides, resistance has occurred in populations of C. cassiicola in China 3,4 . The rapid development of fungicide resistance in C. cassiicola has also been documented in Japan 5–8 …”

Section: Introductionmentioning

confidence: 99%

Two adjacent mutations in the conserved domain of SdhB confer various resistance phenotypes to fluopyram in Corynespora cassiicola

Shi

Zhu

Sun

et al. 2021

Pest Management Science

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BACKGROUND For Corynespora cassiicola (Berk. & M.A. Curtis) C.T. Wei, a necrotrophic pathogen with a broad host range and a worldwide distribution, resistance to fluopyram has been attributed to mutations in SdhB/C/D subunit of the succinate dehydrogenase (SDH) complex. In our previous study, two point mutations in SdhB from isoleucine to valine at position 280 (I280V) and histidine to tyrosine at position 278 (H278Y) showed different resistance phenotypes to fluopyram and boscalid. This research was conducted to explore the correlation between the mutation of SdhB‐I280V or SdhB‐H278Y and resistance to fluopyram or boscalid and its effect on the fitness characteristics of C. cassiicola. RESULTS The sdhB gene in a succinate dehydrogenase inhibitor (SDHI)‐sensitive C. cassiicola strain (wild type) was successfully replaced with the mutant sdhB gene (GTT at position 280, SdhB‐I280V) or with the mutant sdhB gene (TAC at position 278, SdhB‐H278Y,). Compared with the wild‐type strain, the replacement mutants exhibited significantly different resistance phenotypes, with SdhB‐V280 demonstrating moderate resistance to fluopyram and low resistance to boscalid, while SdhB‐Y278 was supersensitive to fluopyram and very highly resistant to boscalid. Both of the mutants exhibited decreased sensitivity to salt stress and increased SDH activity. These two mutations had no effect on the mycelial growth rate, sporulation ability, pathogenicity in vivo, sensitivity to osmotic stress and oxidative stress, cell wall damaging agents, or SHAM. CONCLUSION Two adjacent mutations in the SdhB gene conferred different resistance phenotypes to SDHIs in C. cassiicola, which is important for the development of alternative antifungal fungicides and fluopyram resistance management. © 2021 Society of Chemical Industry.

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Occurrence, Distribution, and Characteristics of Boscalid-Resistant Corynespora cassiicola in China

Cited by 37 publications

References 23 publications

The fungal pathogen Corynespora cassiicola: A review and insights for target spot management on cotton and Soya bean

The fungal pathogen Corynespora cassiicola: A review and insights for target spot management on cotton and Soya bean

Design, synthesis and antifungal/anti‐oomycete activity of pyrazolyl oxime ethers as novel potential succinate dehydrogenase inhibitors

Two adjacent mutations in the conserved domain of SdhB confer various resistance phenotypes to fluopyram in Corynespora cassiicola

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