Occurrence, fate and environmental risk assessment of pharmaceutical compounds in soils amended with organic wastes

Bastos, Marília Camotti; Soubrand, Marilyne; Guet, Thibaut Le; Floch, Éloi Le; Joussein, Emmanuel; Baudu, Michel; Casellas, Magali

doi:10.1016/j.geoderma.2020.114498

Cited by 31 publications

(5 citation statements)

References 45 publications

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“…CBZ was found in all samples at almost the same concentrations (7.77 ng g −1 dm in digested sludge and 2.77 ng g −1 dm in compost), as described by Bastos et al, (2020) [12], who reported concentrations of 224 ng g −1 dm in digested sludge and 112 ng g −1 dm in compost. Concentrations of 10-OH CBZ measured in digested sludge (9.4 ng g −1 dm) and compost (1.4 ng g −1 dm) were similar to those of its parent compound.…”

Section: Compoundsupporting

confidence: 78%

“…Most of the studies have been focused on the evaluation of the adsorption of parent compounds in soil [10,11]. These studies evaluated the adsorption of PhCs in soils, without considering their amendment, and were focused on a limited number of compounds, mainly antibiotics [12]. For example, Wang et al, (2015) [10] confirmed the increase of the sorption capacity of sulphonamides in soils amended with manure.…”

Section: Introductionmentioning

confidence: 99%

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Pharmaceuticals and Their Main Metabolites in Treated Sewage Sludge and Sludge-Amended Soil: Availability and Sorption Behaviour

Martín¹,

Mejías²,

Santos³

et al. 2021

Molecules

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This work evaluated the availability and sorption behaviour of four pharmaceuticals and eight of their metabolites in sewage sludge and sludge-amended soil. Digested sludge and compost were evaluated. The highest levels found in digested sludge corresponded to caffeine (up to 115 ng g−1 dm), ibuprofen (45 ng g−1 dm) and carbamazepine (9.3 ng g−1 dm). The concentrations measured in compost were even lower than in digested sludge. No compound was detected in sludge-amended soils. This fact could be due to the dilution effect after sludge application to soil. Different adsorption capacities in sludge–soil mixtures were measured for the studied compounds at the same spike concentration. In general, except for paraxanthine and 3-hydroxycarbamazepine, the metabolite concentrations measured in the mixtures were almost two-fold lower than those of their parent compounds, which can be explained by their mobility and lixiviation tendency. The log Kd ranged from −1.55 to 1.71 in sludge samples and from −0.29 to 1.18 in soil–sludge mixtures. The log Kd values calculated for compost were higher than those calculated for digested sludge. The obtained results implied that the higher organic carbon content of compost could influence soil contamination when it is applied to soil.

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Section: Compoundsupporting

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Pharmaceuticals and Their Main Metabolites in Treated Sewage Sludge and Sludge-Amended Soil: Availability and Sorption Behaviour

Martín¹,

Mejías²,

Santos³

et al. 2021

Molecules

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show abstract

“…The pollution of surface runoff by pharmaceuticals is related with various activities: the use of solid sludge from WWTP for soil amendments, the use of reclaimed wastewater for soil irrigation, the use of slurry and liquid manure as fertilizers, and urination and defecation of grazing animals and pets (Li 2014;Bastos et al 2020). A minor source is the use of antibiotics for the treatment of plant disease.…”

Section: Surface Runoff and Stormwatermentioning

confidence: 99%

How to decrease pharmaceuticals in the environment? A review

Caban

Stepnowski

2021

Environ Chem Lett

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The global problem of the presence of human and veterinary pharmaceuticals in the environment is under investigation. Despite the increase in the knowledge of its sources, fates and impacts, the assessment of risks and the derived prevention actions are limited to single cases. The predicted increasing trend in the usage of pharmaceuticals forces the various parties involved to think about comprehensive mitigation actions. There are many areas of daily human life and industrial operations where such actions should take place. Thereby, in the presented review, such actions were summarized and divided into the following groups: A. design, synthesis and production of pharmaceuticals, B. prescription, sales and waste handling, C. control of the sources with advanced technologies. As the total amount of proposed actions was found to be quite high, a ranking according to the term of effects was proposed using the pyramid of needs. The advantages of actions taken in the first steps of the pharmaceutical life cycle (acting on the upstream) over end-of-pipe actions and the application of advanced technologies (the downstream option) were discussed, with reference to expert opinions.

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“…Soil microorganisms play a major role in soil quality and longterm sustainability of agricultural terrestrial ecosystems since they control the breakdown of organic matter and hence the net fluxes of carbon and nutrients through the decomposition, mineralization, and immobilization processes (Pankhurst et al, 1996;Nannipieri et al, 2003). However, most studies concerning the impact of emergent contaminants such as antibiotics on terrestrial ecosystems are focused on their presence, behaviour, and risk assessment on human health and aquatic systems (Li, 2014;Bastos et al, 2020;Aydin et al, 2022). It is well known that antimicrobials for veterinary and human medicine can drastically modify non-target organisms living in the agricultural soils and hence alter biodiversity and ecosystem functions.…”

Section: Introductionmentioning

confidence: 99%

Microbial Communities as Affected by Clarithromycin Addition in Four Acid Soils (NW Iberian Peninsula)

et al. 2023

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A laboratory experiment was carried out to investigate the response of the microbial communities in acid agricultural soils located in the NW Iberian Peninsula to the presence of clarithromycin. Four soils, with different organic C content and similar pH, and seven different concentrations of clarithromycin (0.49, 1.95, 7.81, 31.25, 125, 500 and 2,000 mg kg−1 of soil) were used, and microbial estimates were made after 8 and 42 incubation days. The phospholipid fatty acids (PLFA) technique was used to estimate the total microbial biomass and biomass of specific microbial groups as well as the microbial community structure (PLFA pattern). The microbial biomass (total and specific groups) was different in the four studied soils, the lowest values being exhibited by soils with the lowest organic C. The antibiotic addition showed a positive effect on microbial biomass (total and specific groups), especially at the highest dose; the effect being similar or even more accentuated with time passed after the addition (42 days ≥8 days). Principal component analysis (PCA) of the PLFA data carried out with the whole data set showed that the main determining factors of the microbial structure followed the order: soil > time incubation ≥ antibiotic dose. When the PCA was performed individually for each incubation time, the results indicated that microbial communities of the four soils were different. Likewise, for each soil, different microbial communities were observed depending on antibiotic concentration. The microbial biomass and PLFA pattern data were coincidentally showing that the clarithromycin addition favored fungi and G− bacteria more that bacteria and G+ bacteria; the effect being dose-dependent. Our data (microbial biomass, PLFA pattern) also demonstrated that the effect of clarithromycin addition on microbial communities in these four acid agricultural soils persisted even after 42 incubation days.

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Occurrence, fate and environmental risk assessment of pharmaceutical compounds in soils amended with organic wastes

Cited by 31 publications

References 45 publications

Pharmaceuticals and Their Main Metabolites in Treated Sewage Sludge and Sludge-Amended Soil: Availability and Sorption Behaviour

Pharmaceuticals and Their Main Metabolites in Treated Sewage Sludge and Sludge-Amended Soil: Availability and Sorption Behaviour

How to decrease pharmaceuticals in the environment? A review

Microbial Communities as Affected by Clarithromycin Addition in Four Acid Soils (NW Iberian Peninsula)

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