Occurrence of a 3-Methylthiomethylcephem Derivative in a Culture Broth of Cephalosporium Mutant

Kanzaki, Toshihiko; Fukita, Tadazumi; Shirafuji, Hideo; Fujisawa, Yukio; Kitano, Kazuaki

doi:10.7164/antibiotics.27.361

Cited by 22 publications

(10 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is known that deacetoxycephalosporin C is formed through de novo synthesis in the mutants of A. chrysogenum defective in cephalosporin Cor deacetylcephalosporin C productivity (KANZAKI et al 1974). Details are not known about the biosynthesis of deacetoxycephalosporin C in other microorganisms.…”

Section: A Chrysogenum)mentioning

confidence: 99%

“…Compound F-l (Table 2) was detected in culture broths of potent cephalosporin C-producing strains (KANZAKI et al 1974). It may be produced through a chemical or biochemical reaction between cephalosporin C and methanethiol which could originate from added methionine by the action of a methionine-degrading enzyme.…”

Section: A Chrysogenum)mentioning

confidence: 99%

“…In the case of the latter, deacetoxycephalosporin C is synthesized de novo by some of the cephalosporin C-negative mutants (FunsAwA et al 1973(FunsAwA et al , 1975. In contrast, deacetylcephalosporin C may be accumulated through enzymic or chemical hydrolysis of cephalosporin C in other deacetylcephalosporin C-producing microorganisms, since acetylhydrolase has been demonstrated in the culture broth of an A. chrysogenum mutant (FunsAwA et al 1973(FunsAwA et al , 1975KANZAKI et al 1974;LIERSCH et al 1976) and in Streptomyces species . A trace quantity of deacetylcephalosporin C in the fermentation broths of A. chrysogenum was reported to be formed by chemical hydrolysis (HUBER et al 1968).…”

Section: A Chrysogenum)mentioning

confidence: 99%

“…po I ya leurum TUBAKI (1973) Arachnom yces minimus KITANO et al (1975KITANO et al ( , 1977 Anixiopsis peruviana KITANO et al (1975KITANO et al ( , 1977 Spiroidium fuscum KITANO et al (1975KITANO et al ( , 1977 Paecilomyces persicinus PISANO and VELLOZZI (1974) Paecilomyces carneus HIGGENS et al (1974) HO KITANO et al (1975) PISANO and VELLOZZI (1974) HIGGENS et al (1974) KANZAKI et al (1974KANZAKI and FUJISAWA (1976) TRAXLER et al (1975) FUJISAWA and KANzAKI(1975 a Most strains which produce deacetoxycephalosporin C also produce cephalosporin C and deacetylcephalosporin C tf.l ~.…”

Section: A Chrysogenum)mentioning

confidence: 99%

“…Recently, cephalosporin-producing microorganisms have been found to be widely distributed in nature. These include the molds Anixiopsis (KITANO et al , 1977, Arachnomyces (KITANO et al , 1977, Diheterospora (HIGGENS et al 1974), Paecilomyces (HIGGENS et al 1974;KITANO et al 1974;PISANO and VEL-LOZI 1974), Scopulariopsis (HIGGENS et al 1974), and Spiroidium (KITANO et al 1975, and several species of Streptomyces (NAGARAJAN et al 1971;STAPLEY et al 1972;HIGGENS et al 1974;HASEGAWA et al 1975). The successive findings of new cephalosporin-producing fungi at the Takeda Laboratories was due to the advancement of the analytical methods developed for the isolation of fJ-Iactam antibiotics and the use of a specific mutant of Pseudomonas, highly sensitive to ce- NEWTON and ABRAHAM (1955), OLSON et al (1953), CRAWFORD et al (1952) H02CCH(NH2)CH2SCH2CO-…”

Section: Common Namementioning

confidence: 99%

See 4 more Smart Citations

Strain Improvement and Preservation of β-Lactam-Producing Microorganisms

Elander¹

1983

Antibiotics

View full text Add to dashboard Cite

Section: A Chrysogenum)mentioning

confidence: 99%

Section: A Chrysogenum)mentioning

confidence: 99%

Section: A Chrysogenum)mentioning

confidence: 99%

Section: A Chrysogenum)mentioning

confidence: 99%

Section: Common Namementioning

confidence: 99%

See 3 more Smart Citations

Strain Improvement and Preservation of β-Lactam-Producing Microorganisms

Elander¹

1983

Antibiotics

View full text Add to dashboard Cite

Cephalosporins

Roberts¹

2000

Kirk-Othmer Encyclopedia of Chemical Technology

View full text Add to dashboard Cite

CEPHALOSPORINSThe cephalosporins, a subgroup of β-lactam antibiotics, consist of a 4-membered lactam ring fused through the nitrogen and the adjacent tetrahedral carbon atom to a second heterocycle forming a 6-membered dihydrothiazine ring. Other structural features common to all the cephalosporins are a carboxyl group on the dihydrothiazine ring on the carbon next to the ring nitrogen and a functionalized amino group on C-7, the carbon of the β-lactam ring opposite the nitrogen. These features are evidenced in 7-aminocephalosporanic acid [957-68-6] (7-ACA), C 10 H 12 N 2 O 5 S 1. Cephalosporins, like all β-lactam antibiotics, exert their antibacterial effect by interfering with the synthesis of the bacterial cell wall. These antibiotics tend to be "irreversible" inhibitors of cell wall biosynthesis and they are usually bactericidal at concentrations close to their bacteriostatic levels. Cephalosporins are widely used for treating bacterial infections. They are highly effective antibiotics and have low toxicity.

show abstract

β‐Lactam Antibiotics

Andreotti

Biondi

Modugno

2003

Burger's Medicinal Chemistry and Drug Discovery

View full text Add to dashboard Cite

This chapter reviews the history of β‐lactams from the discovery of penicillin in 1928 to the more recently studied and the current trends in the field. The most relevant aspects related to the mechanism of action of β‐lactams are covered, and the various mechanisms of resistance to currently available β‐lactams that bacteria have adopted since the introduction of penicillin are described. A classification of β‐lactamases and their relevance in clinics is also provided. Applications of β‐lactams both in the hospital and in the community are reported, with particular attention to their pharmacokinetic properties, related side effects, and their therapeutic indications. The history and discovery of β‐lactams are described and all major classes are covered: penicillins, cephalosporins, oxacephems, carbacephems, penems, monobactams and nocardicins, carbapenems and trinems, classical (e.g., clavulanic acid, sulbactam, tazobactam), and the more recently disclosed β‐lactamase inhibitors. Several aspects related to the most recent developments in β‐lactams are also covered: new molecules active against difficult Gram‐positive strains or endowed with an antibacterial broad spectrum of action; potent orally active β‐lactams; injectable β‐lactams; and β‐lactamase inhibitors. The chapter concludes with a continuing analysis of the industry‐driven trends and the most recent new application of β‐lactams as inhibitors of protein export in bacteria. Finally, a few very interesting Web addresses and a comprehensive reference list are also provided.

show abstract

Occurrence of a 3-Methylthiomethylcephem Derivative in a Culture Broth of Cephalosporium Mutant

Cited by 22 publications

References 6 publications

Strain Improvement and Preservation of β-Lactam-Producing Microorganisms

Strain Improvement and Preservation of β-Lactam-Producing Microorganisms

Cephalosporins

β‐Lactam Antibiotics

Contact Info

Product

Resources

About