Occurrence of Acanthosis Nigricans, A Benign Condition or Associated with Systemic Disease. A Case-Control Study

Acharya, Riti; Rijal, Arpana

doi:10.3126/njdvl.v14i1.15836

Cited by 3 publications

(3 citation statements)

References 10 publications

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“…Univariate analysis in our study depicted a significant association of AN with BMI, waist circumference, high systolic and diastolic blood pressure, HDL, TG and MS. This is in concordance with a previous case–control study 11 where univariate analysis showed a statistically significant association of high BMI, abnormal waist circumference, diastolic BP and MS with AN. Additionally, a significant association of AN noted with fasting blood sugar, while no association of AN with abnormal HDL was noted.…”

Section: Discussionsupporting

confidence: 93%

“…Our study, on multivariate analysis, demonstrated a significant association between abnormal waist circumference, high systolic and diastolic blood pressure, and high TG levels with AN. In the previous study by Acharya et al, 11 multivariate analysis showed a significant association of abnormal waist circumference and MS with AN, while no such association was noted with abnormal HDL level.…”

Section: Discussionmentioning

confidence: 76%

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Association of acanthosis nigricans with metabolic syndrome – An analytic cross-sectional study

Choudhary¹,

Srivastava²,

Saoji³

et al. 2023

Anais Brasileiros de Dermatologia

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 76%

Association of acanthosis nigricans with metabolic syndrome – An analytic cross-sectional study

Choudhary¹,

Srivastava²,

Saoji³

et al. 2023

Anais Brasileiros de Dermatologia

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“…Acharya et al in their case -control study, on univariate analysis showed a statistically significant association of fasting blood sugar (OR=3.98; CI=95;P=0.01). 16 They have not done univariate analysis of insulin, HOMA-IR. Table 6 shows week correlation of HOMA-IR with acanthosis nigricans severity with coefficient of 0.0798, which was statistically insignificant with P-value of 0.478 (P > 0.05).…”

Section: Discussionmentioning

confidence: 99%

Acanthosis nigricans: a clinical marker of insulin resistance

et al. 2017

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Background: Very little information is available regarding the association of acanthosis nigricans with insulin resistance from rural areas of India. Therefore this study was carried out with the aim and objectives to study the association between acanthosis nigricans and insulin resistance and to evaluate correlation of acanthosis nigricans severity, neck severity and neck texture severity with fasting blood sugar & serum insulin especially in this rural part of central India.Methods: In this cross sectional study with comparative group, total 162 age and sex matched subjects were divided into two groups of cases (81) with acanthosis nigricans and comparative subjects (81) without acanthosis nigricans. The severity acanthosis nigricans was assessed using the Burke’s quantitative scale. Fasting blood sugar and fasting insulin levels were estimated to know the Homeostasis model assessment of insulin resistance (HOMA-IR) values. Data was analyzed by using appropriate statistical tests.Results: The age range was 20 to 55 years with the mean of 32.82 ± 10.19 years for cases and 33.67 ± 8.09 for comparative subjects. Univariate analysis which showed significant association of acanthosis nigricans with fasting insulin and HOMA-IR with significant odds ratios and p value (p =0.0001) respectively. Fasting blood sugar showed greater risk of association in cases but it was statistically insignificant with p-value of (p =0.32). Spearman rank coefficient correlation showed weak correlation of HOMA-IR with acanthosis nigricans severity, neck severity and neck texture severity, but showed positive correlation of fasting insulin with acanthosis nigricans severity, neck severity and neck texture severity, with statistically significant P-value (p <0.05).Conclusions: Acanthosis nigricans was strongly associated with insulin resistance with significant odds ratio and statistical significant p value (P < 0.05). Acanthosis nigricans severity, neck severity and neck texture severity showed positive correlation with fasting serum insulin with statistically significant p value (P <0.05).

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A Cross-sectional Analytical Study of Morphological Patterns of Acanthosis Nigricans and Its Association with Components of Metabolic Syndrome

Parmar,

Pala

2024

Current Medical Issues

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Background: Acanthosis nigricans (AN) is a dermatosis that manifests as asymptomatic and symmetrical darkening, affecting the skin of intertriginous areas. It is a marker of insulin resistance and is usually associated with metabolic syndrome (MS). The present study was conducted to study the morphological patterns of AN and to assess its correlation with different components of MS. Methodology: Using the purposive sampling technique (1-year period), 100 patients fulfilling the case definition of AN were enrolled based on the inclusion and exclusion criteria. A detailed history and a cutaneous examination (color, texture, and sites of AN) were done. Anthropometric measurements and scoring of the AN were done. Investigations were reviewed. Data were recorded, and MS was diagnosed using the National Cholesterol Education Program’s Adult Panel III criteria. The data were analyzed using Microsoft Excel 13 software. Results: The mean age was 36.9 ± 10.1 years, with a male-to-female ratio of 1:1.38. The mean duration of AN was 18.8 ± 12.5 months. Seventy percent of cases had involvement of two or more sites. MS was present in 55% of cases of AN. Gender, duration of AN, site of AN, neck and axilla severity, and total cholesterol were not statistically significantly associated with MS (P > 0.05). Its association with systolic and diastolic blood pressure, waist circumference, fasting blood sugar, and high triglyceride was found to be statistically significant (P < 0.05). A low high-density lipoprotein level was found to be highly significant (P < 0.01). On applying the Chi-square test, all five parameters of MS had a significant association with AN. Conclusion: Understanding the relationship between AN and MS is important, as patients with AN are at risk for all the components of MS individually and collectively.

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Occurrence of Acanthosis Nigricans, A Benign Condition or Associated with Systemic Disease. A Case-Control Study

Cited by 3 publications

References 10 publications

Association of acanthosis nigricans with metabolic syndrome – An analytic cross-sectional study

Association of acanthosis nigricans with metabolic syndrome – An analytic cross-sectional study

Acanthosis nigricans: a clinical marker of insulin resistance

A Cross-sectional Analytical Study of Morphological Patterns of Acanthosis Nigricans and Its Association with Components of Metabolic Syndrome

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