Occurrence of Acute Myeloid Leukemia in Young Pregnant Women

Menezes, Juliane; Emerenciano, Mariana; Pimenta, Flávia Cristina Fernandes; Filho, Gilson Guedes de Araújo; Magalhães, Isis Quezado; Santana, Mariana Oliveira; Vaskuez, Marina Lipkin; Renault, Ilana Zalcberg; Pombo‐de‐Oliveira, Maria S.

doi:10.4137/cmbd.s823

Cited by 3 publications

(3 citation statements)

References 19 publications

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“…Firstly, the mother who needs cancer therapy and secondly the developing fetus who needs to be protected from the adverse effects of the antineoplastic drugs [14]. Several researchers have reported small series' of patient with acute leukemia in pregnancy [15][16][17][18][19][20][21][22][23][24][25].…”

Section: Discussionmentioning

confidence: 99%

Acute leukemia in pregnancy: Case series from a tertiary care institute

Rk¹,

HP²,

Patel³

et al. 2021

J Med Sci Res.

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Background: Acute leukemia in pregnancy is estimated to occur in less than one in one lakh pregnancies. Management of these patients differs by the trimester in which they present, because of the differential sensitivity of the fetus to chemotherapy during the three trimesters. Because of the rarity of this situation, there is scarcity of data on the management of these patients. Materials and method: We included patients with acute leukemia diagnosed and treated during pregnancy at our institute and reviewed 3 successive patients for this case series. Results and conclusion: Acute leukemia in pregnancy presents a unique challenge for treatment and requires multidisciplinary co-ordination for treatment. When judiciously managed, good outcomes of disease of mother and fetus can be achieved. Our three patients included one in each trimester; the first trimester patient underwent medical termination of pregnancy and has successfully completed treatment. The second trimester patient underwent induction chemotherapy and delivered a healthy baby. The patient diagnosed in the third trimester delivered a pre-term healthy baby during treatment and continues to be on chemotherapy.

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Section: Discussionmentioning

confidence: 99%

Acute leukemia in pregnancy: Case series from a tertiary care institute

Rk¹,

HP²,

Patel³

et al. 2021

J Med Sci Res.

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“…There are numerous reports of the successful management of AML in pregnancy and few reports of vertical transmission of acute leukemia from the mother to the fetus [48][49][50]. The spontaneous remission of acute leukemia after the termination of pregnancy and the following rare forms of AML have been reported: erythroleukemia, t(8,21) AML with granulocytic sarcoma causing spinal cord compression, and AML mimicking HELLP (hemolysis, elevated liver enzymes and low platelet counts) syndrome [50][51][52][53].…”

Section: Aml In Pregnancymentioning

confidence: 99%

“…Although acute leukemia is a rare event in pregnancy, it may be associated with life-threatening complications to both the mother and the fetus [49]. Therefore, acute leukemia diagnosed during pregnancy should be treated promptly as delay in treatment is associated with higher maternal mortality, but decision on the choice of treatment for acute leukemia during pregnancy should be case-dependent [50,54].…”

Section: Aml In Pregnancymentioning

confidence: 99%

Update on Leukemia in Pregnancy

Al-Anazi¹

2015

Leukemias - Updates and New Insights

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Leukemia is a rare event in pregnancy. Acute leukemia represents % of leukemias occurring during pregnancy with AML accounting for two thirds of these cases.During the first trimester of pregnancy, standard chemotherapy has a teratogenicity rate of up to % depending on the specific agent employed. Exposure to cytotoxic agents during the second and third trimesters is not teratogenic but may predispose the fetus to growth retardation, premature delivery and bone marrow suppression.Additionally, the mother and the fetus are at risk of thromboembolism and sepsis.

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Acute myeloid leukemia in the pregnant patient

Thomas

2015

European J of Haematology

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Although acute myeloid leukemia (AML) mostly occurs in older patients, it could be seen in women of childbearing age. It is therefore not surprising that in some patients the management of AML will be complicated by a coexistent pregnancy. However, the association of leukemia and pregnancy is uncommon. Its incidence is estimated to be 1 in 75,000 to 100,000 pregnancies. During pregnancy, most leukemias are acute: two thirds are myeloid and one third are lymphoblastic. There is no standard approach for this clinical dilemma, in part because of Accepted ArticleThis article is protected by copyright. All rights reserved.variables such as the type of AML, the seriousness of the symptoms, and the patient's personal beliefs. In many cases, the diagnostic work up has to be altered because of the pregnancy, and often available treatments have varying risks to the fetus. While chemotherapy is reported to have some risks during the first trimester, it is admitted that it can be administered safely during the second and the third trimesters.

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Occurrence of Acute Myeloid Leukemia in Young Pregnant Women

Cited by 3 publications

References 19 publications

Acute leukemia in pregnancy: Case series from a tertiary care institute

Acute leukemia in pregnancy: Case series from a tertiary care institute

Update on Leukemia in Pregnancy

Acute myeloid leukemia in the pregnant patient

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