Occurrence of affective disorders compared to other psychiatric disorders in children and adolescents with 22q11.2 deletion syndrome

Jolin, Edith M.; Weller, Ronald A.; Weller, Elizabeth B.

doi:10.1016/j.jad.2010.11.025

Cited by 41 publications

(38 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As stated previously, specific phobia is the most common anxiety disorder at all ages in our study. These findings were consistent with previous studies [1,3]. Interestingly, OCD occurred rather infrequently compared to the results found in other studies on VCFS [10].…”

Section: Discussionsupporting

confidence: 93%

“…This rate is considerably higher than the 5 % estimated prevalence in school age population without VCFS [26]. Interestingly, the rate of depression in our sample is higher than the results reported in some previous studies in youth with VCFS [1,3]. Sample sizes or differences in age ranges could account for some of these differences.…”

Section: Discussioncontrasting

confidence: 83%

“…Depression and anxiety disorders in children have recently aroused great interest among researchers in the field of velo-cardio-facial syndrome [1][2][3][4][5]. These pathologies are highly prevalent, can have a dramatic impact on the daily lives of patients and their families and can affect future development.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Depression and anxiety disorders in children and adolescents with velo-cardio-facial syndrome (VCFS)

Fabbro

Rizzi

Schneider

et al. 2012

Eur Child Adolesc Psychiatry

View full text Add to dashboard Cite

Velo-cardio-facial syndrome (VCFS) is characterized by a high prevalence of depression and anxiety disorders in childhood and adolescence. These disorders are a source of great impairment in everyday functioning, as well as important risk factors for the emergence of later psychotic disorders. Impairment in daily and social functioning as well as loss of IQ throughout growth are also are well-established correlates of the VCFS. This study aimed to confirm the high prevalence of depression and anxiety disorders. The second objective was to ascertain the correlation between anxious and depressive symptoms and the decline in adaptive and cognitive functioning. A total of 73 children and adolescents with VCFS (mean age 11.9 years) underwent psychiatric evaluation. Subjects were further divided into four age groups: ages 6-9, 9-12, 12-15 and 15-18 years. Assessments measuring intelligence, anxious and depressive symptoms, and adaptation skills reported by parents were submitted to a subsample of 62 children (mean age 12.2 years); 62.2 % of the sample showed an anxiety disorder, specific phobia being the most represented at all ages. Lifetime depression concerned 27 % of the sample, peaking at age 12-15 years. Anxious and depressive symptoms and low IQ were significantly associated with low adaptive functioning. Anxiety and depression are common disorders in children and adolescents with VCFS and have a great impact on adaptive functioning. Clinicians should pay great attention to diagnosis and treatment.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussioncontrasting

confidence: 83%

See 1 more Smart Citation

Depression and anxiety disorders in children and adolescents with velo-cardio-facial syndrome (VCFS)

Fabbro

Rizzi

Schneider

et al. 2012

Eur Child Adolesc Psychiatry

View full text Add to dashboard Cite

show abstract

“…These rare syndromes often show up across multiple diagnostic categories, suggesting risk of neurobehavioral impairment that is modified by other developmental, environmental, or genetic factors. For example, deletion of chromosome 22q11.2 results in velocardiofacial syndrome (VCFS), which is associated with diagnosis of intellectual disability, ADHD, and ASD in childhood (Hooper et al, 2013), mood disorders in adolescence (Jolin et al, 2012), and psychosis in adulthood (Green et al, 2009). As an even rarer example, a balanced translocation in one family identified disruption of the DISC1 gene as a highly penetrant risk factor for schizophrenia and mood disorders (Millar et al, 2000).…”

Section: Rare Simple Genetic Phenocopies Could Reveal New Treatment mentioning

confidence: 99%

Intervention in the Context of Development: Pathways Toward New Treatments

Veenstra‐VanderWeele

Warren

2014

Neuropsychopharmacol

View full text Add to dashboard Cite

Neuropsychiatric disorders vary substantially in age of onset but are best understood within the context of neurodevelopment. Here, we review opportunities for intervention at critical points in developmental trajectories. We begin by discussing potential opportunities to prevent neuropsychiatric disorders. Once symptoms begin to emerge, a number of interventions have been studied either before a diagnosis can be made or shortly after diagnosis. Although some of these interventions are helpful, few are based upon an understanding of pathophysiology, and most ameliorate rather than resolve symptoms. As such, in the next portion of the review, we turn our discussion to genetic syndromes that are rare phenocopies of common diagnoses such as autism spectrum disorder or schizophrenia. Cellular or animal models of these syndromes point to specific regulatory or signaling pathways. As examples, findings from the mouse models of Fragile X and Rett syndromes point to potential treatments now being tested in randomized clinical trials. Paralleling oncology, we can hope that our treatments will move from nonspecific, like chemotherapies thrown at a wide range of tumor types, to specific, like the protein kinase inhibitors that target molecularly defined tumors. Some of these targeted treatments later show benefit for a broader, yet specific, array of cancers. We can hope that medications developed within rare neurodevelopmental syndromes will similarly help subgroups of patients with disruptions in overlapping signaling pathways. The insights gleaned from treatment development in rare phenocopy syndromes may also teach us how to test treatments based upon emerging common genetic or environmental risk factors.

show abstract

“…Associations between rare variants and psychiatric phenotypes that have been published so far may reflect this trend. For example, 22q11 deletion was initially found to be overrepresented in patients with schizophrenia, 4 mood disorders, 5 anxiety disorders and attention-deficit/ hyperactivity disorder, 6 pervasive developmental disorders and various levels of intellectual deficit. 5,8,9 The same pattern of indiscriminate association of many psychiatric phenotypes (e.g., mental retardation, schizophrenia, autism) and neurologic disorders (e.g., epilepsy) with chromosomal variants (e.g., translocation disrupting DISC1 [10][11][12][13] ) and copy number variations (CNVs) [14][15][16][17] is increasingly reported as investigators search for these rare variants in patients with various disorders or in carriers of a specific rare variant.…”

Section: Psychiatric Genetic Researchmentioning

confidence: 99%

The 1000 Genomes Project: deep genomic sequencing waiting for deep psychiatric phenotyping

Joober

2011

jpn

View full text Add to dashboard Cite

Occurrence of affective disorders compared to other psychiatric disorders in children and adolescents with 22q11.2 deletion syndrome

Cited by 41 publications

References 39 publications

Depression and anxiety disorders in children and adolescents with velo-cardio-facial syndrome (VCFS)

Depression and anxiety disorders in children and adolescents with velo-cardio-facial syndrome (VCFS)

Intervention in the Context of Development: Pathways Toward New Treatments

The 1000 Genomes Project: deep genomic sequencing waiting for deep psychiatric phenotyping

Contact Info

Product

Resources

About