1995
DOI: 10.1182/blood.v85.7.1736.bloodjournal8571736
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Occurrence of allogeneic HLA and non-HLA antibodies after transfusion of prestorage filtered platelets and red blood cells: a prospective study [see comments]

Abstract: The incidence and consequences of HLA and non-HLA immunization were evaluated in 229 patients with aplastic thrombocytopenia. All patients were transfused with prestorage filtered red blood cells and platelets. On admission, 29 patients presented with HLA antibodies due to prior immunization by pregnancy and/or blood transfusions. Of the 200 patients showing no detectable HLA antibodies on admission, 164 could be evaluated. HLA antibodies developed in 2.7% (3 of 112) of the patients with a negative risk histor… Show more

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Cited by 150 publications
(62 citation statements)
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“…Panreactive antibodies were observed by Kurz et al 7 in 26 percent of patients, while, in 20 percent, they were associated with HLA antibodies. In studies published by Novotny et al 27 and Godeau et al, 28 most antibodies with undefined specificity were not associated with refractoriness to transfused platelets. Godeau et al 28 interpret these antibodies as autoantibodies.…”
Section: Discussionmentioning
confidence: 85%
“…Panreactive antibodies were observed by Kurz et al 7 in 26 percent of patients, while, in 20 percent, they were associated with HLA antibodies. In studies published by Novotny et al 27 and Godeau et al, 28 most antibodies with undefined specificity were not associated with refractoriness to transfused platelets. Godeau et al 28 interpret these antibodies as autoantibodies.…”
Section: Discussionmentioning
confidence: 85%
“…In a previous study, Novotny et al (1995) showed that 19% of their haemato-oncological patients have HLA antibodies, but only 2 . 7% of patients with no history of prior immunization, develop HLA antibodies if transfused with leucocyte-depleted blood products.…”
Section: Discussionmentioning
confidence: 94%
“…They report a decrease in reaction rate from 29% with leucocyte reduction to 17% with plasma reduction (Heddle et al, 1999). Another group reported a very low incidence of transfusion reactions in patients treated with both plasma-and white-cell-reduced transfusions from the beginning of their transfusion course (Novotny et al, 1995). To our knowledge no data exist comparing combined leucocyte and plasma-reduced transfusions with either single technique alone.…”
Section: Discussionmentioning
confidence: 97%