Occurrence of antibiotics and antibiotic resistance genes in WWTP effluent-receiving water bodies and reclaimed wastewater treatment plants

Wang, Rumeng; Ji, Min; Zhai, Hongchen; Guo, Yujing; Liu, Yuan

doi:10.1016/j.scitotenv.2021.148919

Cited by 127 publications

(38 citation statements)

References 80 publications

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“…Here, physicochemical factors mainly refer to the physicochemical properties of livestock and poultry breeding wastewater and include temperature, pH, electrical conductivity (EC), total nitrogen (TN), total phosphorus (TP), ammonia nitrogen, nitrate nitrogen, organic matter and heavy metals, which indirectly affect antibiotic resistance mainly by affecting the compositions of microbial communities. Studies have shown that total nitrogen, ammonia nitrogen and total phosphorus were significantly and positively correlated with the abundance of sul1, sul2, tetA, tetB, tetC and qnsR ( 23 , 70 , 71 ); total organic carbon was significantly and positively correlated with fexA, fexB, cfr, sul1, tetW, tetO, tetQ and tetS ( 72 ). In addition, physicochemical factors can indirectly affect the abundance of ARGs by affecting the morphology of free ARGs.…”

Section: Factors Influencing Args Removal During Livestock Wastewater...mentioning

confidence: 99%

Removal of antibiotic resistance genes during livestock wastewater treatment processes: Review and prospects

Huang

Hong

et al. 2022

Front. Vet. Sci.

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Antibiotic resistance genes (ARGs) are emerging pollutants that have received extensive attention. Many different types of ARGs exist in livestock wastewater. If not effectively treated, they can threaten animal production, public health and the ecological safety of the surrounding environment. To address the high risk of livestock wastewater contamination by ARGs, the effects of different wastewater treatment processes on ARGs and their influencing factors and mechanisms are reviewed herein. Additionally, the current problems associated with removal of ARGs are discussed, and future research is proposed.

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Section: Factors Influencing Args Removal During Livestock Wastewater...mentioning

confidence: 99%

Removal of antibiotic resistance genes during livestock wastewater treatment processes: Review and prospects

Huang

Hong

et al. 2022

Front. Vet. Sci.

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“…It is also a hormone and endocrine disrupting chemical (EDC) because of its effect on the growth and reproduction of fish ( Celino-Brady, Lerner & Seale, 2021 ). The DIA also can induce antibiotic-resistant bacteria in the water environment ( Wang et al, 2021 ). DIA has been reported to have a significant behavioural effect on fish at a medium concentration of 1.0 ± 0.15 µg/L ( Lorenzi, Choe & Schlenk, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Determination and risk assessment of pharmaceutical residues in the urban water cycle in Selangor Darul Ehsan, Malaysia

Hanafiah

Mohtar

Manan

et al. 2023

PeerJ

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The environmental fate of non-steroidal anti-inflammatory drugs (NSAIDs) in the urban water cycle is still uncertain and their status is mainly assessed based on specific water components and information on human risk assessments. This study (a) explores the environmental fate of NSAIDs (ibuprofen, IBU; naproxen, NAP; ketoprofen, KET; diazepam, DIA; and diclofenac, DIC) in the urban water cycle, including wastewater, river, and treated water via gas chromatography-mass spectrophotometry (GCMS), (b) assesses the efficiency of reducing the targeted NSAIDs in sewage treatment plant (STP) using analysis of variance (ANOVA), and (c) evaluates the ecological risk assessment of these drugs in the urban water cycle via teratogenic index (TI) and risk quotient (RQ). The primary receptor of contaminants comes from urban areas, as a high concentration of NSAIDs is detected (ranging from 5.87 × 103 to 7.18 × 104 ng/L). The percentage of NSAIDs removal in STP ranged from 25.6% to 92.3%. The NAP and KET were still detected at trace levels in treated water, indicating the persistent presence in the water cycle. The TI values for NAP and DIA (influent and effluent) were more than 1, showing a risk of a teratogenic effect. The IBU, KET, and DIC had values of less than 1, indicating the risk of lethal embryo effects. The NAP and DIA can be classified as Human Pregnancy Category C (2.1 > TI ≥ 0.76). This work proved that these drugs exist in the current urban water cycle, which could induce adverse effects on humans and the environment (RQ in high and low-risk categories). Therefore, they should be minimized, if not eliminated, from the primary sources of the pollutant (i.e., STPs). These pollutants should be considered a priority to be monitored, given focus to, and listed in the guideline due to their persistent presence in the urban water cycle.

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“…Antibiotics are a prominent group of organic micropollutants (OMPs) frequently detected in wastewater treatment plants (WWTPs) due to their increasing use in modern societies. , As a consequence, WWTPs have become global hotspots for the development of antibiotic-resistant genes and bacteria, posing a serious environmental and health risk. − Among antibiotics, sulfonamides are of particular importance because of their intensive utilization worldwide, with sulfamethoxazole (SMX) being the most broadly consumed one. , In 2020, due to this growing concern, SMX was included in the “Surface Water Watchlist” published by the Water Framework Directive of the European Union to monitor and gather data about its potential risks to the aquatic environment…”

Section: Introductionmentioning

confidence: 99%

Sulfamethoxazole Enhances Specific Enzymatic Activities under Aerobic Heterotrophic Conditions: A Metaproteomic Approach

Kennes-Veiga

Trueba-Santiso

Gallardo-Garay

et al. 2022

Environ. Sci. Technol.

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The growing concern about antibiotic-resistant microorganisms has focused on the sludge from wastewater treatment plants (WWTPs) as a potential hotspot for their development and spread. To this end, it seems relevant to analyze the changes on the microbiota as a consequence of the antibiotics that wastewater may contain. This study aims at determining whether the presence of sulfamethoxazole (SMX), even in relatively low concentrations, modifies the microbial activities and the enzymatic expression of an activated sludge under aerobic heterotrophic conditions. For that purpose, we applied a metaproteomic approach in combination with genomic and transformation product analyses. SMX was biotransformed, and the metabolite 2,4(1H,3H)-pteridinedione-SMX (PtO-SMX) from the pterin-conjugation pathway was detected at all concentrations tested. Metaproteomics showed that SMX at 50−2000 μg/L slightly affected the microbial community structure, which was confirmed by DNA metabarcoding. Interestingly, an enhanced activity of the genus Corynebacterium and specifically of five enzymes involved in its central carbon metabolism was found at increased SMX concentrations. Our results suggest a role of Corynebacterium genus on SMX risks mitigation in our bioreactors.

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Occurrence of antibiotics and antibiotic resistance genes in WWTP effluent-receiving water bodies and reclaimed wastewater treatment plants

Cited by 127 publications

References 80 publications

Removal of antibiotic resistance genes during livestock wastewater treatment processes: Review and prospects

Removal of antibiotic resistance genes during livestock wastewater treatment processes: Review and prospects

Determination and risk assessment of pharmaceutical residues in the urban water cycle in Selangor Darul Ehsan, Malaysia

Sulfamethoxazole Enhances Specific Enzymatic Activities under Aerobic Heterotrophic Conditions: A Metaproteomic Approach

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