Occurrence of antibiotics and risk of antibiotic resistance evolution in selected Kenyan wastewaters, surface waters and sediments

Kairigo, Pius K.; Ngumba, Elijah; Sundberg, Lotta‐Riina; Gachanja, Anthony; Tuhkanen, Tuula

doi:10.1016/j.scitotenv.2020.137580

Cited by 150 publications

(77 citation statements)

References 49 publications

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“…Other compounds detected at higher concentrations include crotamiton (1.8 ng/g OC) and diazepam (1.5 ng/g OC). The concentrations of the antibiotic sulfamethoxazole measured in this study (0.21 ng/g OC) fall below the concentrations reported by Kairigo et al [25] in sediments from Mwania river in Kenya by about one order of magnitude. This is probably due to differences in consumption patterns and the impact of municipal waste in the study area, since their study was performed in an urban setting.…”

Section: Occurrence and Distribution Of Pollutants In Sedimentscontrasting

confidence: 88%

“…Although many African laboratories are increasing their efforts to monitor the occurrence of CECs in African aquatic ecosystems [44], this research field is yet to be fully explored. Many previous studies from Kenya focused largely on urban areas with a limited number of compounds investigated [5,17,23,25,28,47,51]. Among the studies on pesticides in the environment, the previous work largely focused on organochlorine and organophosphates compounds [43,50,59], although the next generation of pesticides including phosphoric esters and neonicotinoids are currently in use and have been found in Kenyan surface water [23].…”

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confidence: 99%

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Multi-compartment chemical characterization and risk assessment of chemicals of emerging concern in freshwater systems of western Kenya

et al. 2020

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Background Within the last decades, there has been increasing research on the occurrence of chemicals of emerging concern (CECs) in aquatic ecosystems due to their potential adverse effects on freshwater organisms and risk to human health. However, information on CECs in freshwater environments in sub-Saharan countries is very limited. Here, we investigated the occurrence of CECs in snails and sediments collected from 48 sites within the Lake Victoria South Basin, Kenya, which have been previously investigated for water contamination. Samples were analyzed by liquid chromatography coupled to high-resolution mass spectrometry (LC-HRMS) with a target list of 429 compounds. Results In total, 30 compounds have been detected in snails and 78 in sediment samples, compared to 79 previously identified compounds in water. By extending the monitoring of CECs to snails and sediments, we found 68 compounds that were not previously detected in water. These compounds include the anti-cancer drug anastrozole, detected for the first time in the Kenyan environment. Individual compound concentrations were detected up to 480 ng/g wet weight (N-ethyl-o-toluenesulfonamide) in snails and 110 ng/g organic carbon (pirimiphos-methyl) in sediments. Higher contaminant concentrations were found in agricultural sites than in areas not impacted by anthropogenic activities. Crustaceans were the organisms at greatest toxic risk from sediment contamination [toxic unit (TU) up to 0.99] with diazinon and pirimiphos-methyl driving this risk. Acute and chronic risks to algae were driven by diuron (TU up to 0.24), whereas fish were found to be at low-to-no acute risk (TU up to 0.007). Conclusions The compound classes present at the highest frequencies in all matrices were pesticides and biocides. This study shows substantial contamination of surface water in rural western Kenya. By filling data gaps on contamination of sediments and aquatic biota, our study reveals that CECs pose a substantial risk to environmental health in Kenya demanding for monitoring and mitigation.

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Section: Occurrence and Distribution Of Pollutants In Sedimentscontrasting

confidence: 88%

mentioning

confidence: 99%

Multi-compartment chemical characterization and risk assessment of chemicals of emerging concern in freshwater systems of western Kenya

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Other compounds detected at higher concentrations include crotamiton (1.8 ng/g OC) and diazepam (1.5 ng/g OC). The concentrations of the antibiotic sulfamethoxazole measured in this study (0.21 ng/g OC) fall below the concentrations reported by Kairigo et al (2020) in sediments from Mwania river in Kenya by about one order of magnitude. This is probably due to differences in consumption patterns and the impact of municipal waste in the study area since their study was performed in an urban setting.…”

Section: Occurrence and Distribution Of Pollutants In Sedimentscontrasting

confidence: 88%

Multi-compartment chemical characterization and risk assessment of chemicals of emerging concern in freshwater systems of western Kenya

Kandie

Krauß

Massei

et al. 2020

Preprint

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Background Within the last decades, there has been increasing research on the occurrence of chemicals of emerging concern (CECs) in aquatic ecosystems due to their potential adverse effects on freshwater organisms and risk to human health. However, information on CECs in freshwater environments in sub-Saharan countries is very limited. Here, we investigated the occurrence of CECs in snails and sediments collected from 48 sites within the Lake Victoria South Basin, Kenya, which have been previously investigated for water contamination. Samples were analyzed by liquid chromatography coupled to high resolution mass spectrometry (LC-HRMS) with a target list of 429 compounds. Results In total, 30 compounds have been detected in snails and 78 in sediment samples, compared to 79 previously identified compounds in water. By extending the monitoring of CECs to snails and sediments, we found 68 compounds that were not previously detected in water. These compounds include the anti-cancer drug anastrozole, detected for the first time in the Kenyan environment. Individual compound concentrations were detected up to 480 ng/g wet weight (N-ethyl-o-toluenesulfonamide) in snails and 110 ng/g organic carbon (pirimiphos-methyl) in sediments. Higher contaminant concentrations were found in agricultural sites than in areas not impacted by anthropogenic activities. Crustaceans were the organisms at greatest toxic risk from sediment contamination (toxic unit (TU) up to 0.99) with diazinon and pirimiphos-methyl driving this risk. Acute and chronic risks to algae were driven by diuron (TU up to 0.24), whereas fish were found to be at low to no acute risk (TU up to 0.007). Conclusions The compound classes present at highest frequencies in all matrices were pesticides and biocides. This study shows substantial contamination of surface water in rural western Kenya. By filling data gaps on contamination of sediments and aquatic biota, our study reveals that CECs pose a substantial risk on environmental health in Kenya demanding for monitoring and mitigation.

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“…Ciprofloxacin has been detected at lower concentration in Ugandan Lake Victoria at 91% frequency [23]. Its presence has also been reported in surface waters in Nigeria [58] and Kenya [59]. Occurrence of Metronidazole in African aquatic environment has been reported to be 100 times more than the concentration reported in European waters [29].…”

Section: Antibioticsmentioning

confidence: 99%

Occurrence and risk assessment of selected pharmaceuticals in water and sediments of Usuma Dam, Abuja, Nigeria

Ilechukwu

Okonkwo

Olusina

et al. 2021

International Journal of Environmental Analytical Chemistry

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The occurrence and ecological risk associated with nine pharmaceuticals; Ciprofloxacin, Metronidazole, Amoxycillin, Trimethoprim, Tetracycline, Sulfamethoxazole, Ibuprofen, Diclofenac and Paracetamol were investigated in water and sediments of Usuma Dam, Abuja, Nigeria. The samples were extracted with solid phase extraction and analysed with high performance liquid chromatography coupled with UV/VIS detector (HPLC-UV/VIS). Metronidazole with a concentration range of 191.11-572.73 ng/L and Trimethoprim with a concentration range of 0.27-0.42 µg/g d.w. were the predominant antibiotics in the water and sediments respectively. Ibuprofen was the only analgesics detected in the samples. The ecological risk assessed with the worst observed data for each pharmaceutical in the samples showed that Amoxycillin and Ibuprofen pose a high toxic risk to aquatic life in the dam while Trimethoprim and Ciprofloxacin could result in medium ecological risk. The results of this study draw attention to the occurrence and ecological risks of pharmaceuticals to aquatic life.

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Occurrence of antibiotics and risk of antibiotic resistance evolution in selected Kenyan wastewaters, surface waters and sediments

Cited by 150 publications

References 49 publications

Multi-compartment chemical characterization and risk assessment of chemicals of emerging concern in freshwater systems of western Kenya

Multi-compartment chemical characterization and risk assessment of chemicals of emerging concern in freshwater systems of western Kenya

Multi-compartment chemical characterization and risk assessment of chemicals of emerging concern in freshwater systems of western Kenya

Occurrence and risk assessment of selected pharmaceuticals in water and sediments of Usuma Dam, Abuja, Nigeria

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