Occurrence of antibody to salivary duct epithelium in Sjogren's disease, rheumatoid arthritis, and other arthritides. A clinical and laboratory study.

Macsween, R. N. M.; Goudie, R. B.; Anderson, John R.; Armstrong, E M; Murray, M A; Mason, David R.; Jasani, M K; Boyle, J A; Buchanan, W. Watson; Williamson, John

doi:10.1136/ard.26.5.402

Cited by 86 publications

(25 citation statements)

References 30 publications

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“…Its absence is consistent with the observation that the salivary duct antibody is more often observed in Group A patients. 14 The glomeruli were normal and free of immunoglobulin in the patients with renal tubular acidosis. Serum complement levels were similarly normal.…”

Section: Discussionmentioning

confidence: 99%

Renal Tubular Acidosis, Glomerulonephritis and Immunologic Factors in Sjogren's Syndrome

Talal

Zisman

Schur

1968

Arthritis & Rheumatism

161

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Urinary acidification was impaired in 6 of 12 patients with Sjogren's syndrome (SS) studied before and during the administration of ammonium chloride. Renal tubular acidosis was overt in 3 patients and subclinical in 2. The sixth patient had glomerulonephritis. Precipitating antibodies to tissue antigens were studied in 70 patients with SS. The group with renal disease had the greatest reactivity, and the only reactivity to heat denatured DNA. None of the 70 patients reacted with native DNA, and only one with nucleoprotein.

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Section: Discussionmentioning

confidence: 99%

Renal Tubular Acidosis, Glomerulonephritis and Immunologic Factors in Sjogren's Syndrome

Talal

Zisman

Schur

1968

Arthritis & Rheumatism

161

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“…The rheumatoid factor (RF), commonly found in autoimmune diseases such as SLE and SS [4,5,25,26], was also detected in Act1-deficient mice but not in their littermates (Fig. 4B).…”

Section: Act1-deficient Mice Develop Sle-like Glomerulonephritismentioning

confidence: 99%

“…Sjögren's syndrome (SS) is a systemic autoimmune disorder characterized by profound lymphocytic infiltration of the lacrimal and salivary glands [3][4][5]. This chronic inflammatory process leads to diminished function of the glands resulting in symptoms of xerophthalmia (dry eyes) or xerostomia (dry mouth).…”

Section: Introductionmentioning

confidence: 99%

“…This chronic inflammatory process leads to diminished function of the glands resulting in symptoms of xerophthalmia (dry eyes) or xerostomia (dry mouth). B cell hyper-activation is a predominant feature of SS, which in human patients is characterized by hypergammaglobulinemia and production of autoantibodies [3][4][5][6][7]. The occurrence of SS-A/Ro and SS-B/La, the two most commonly detected autoantibodies in SS patients, has been directly associated with recurrent lymphocyte infiltration of the exocrine glands, tissue damage and secretory dysfunction.…”

Section: Introductionmentioning

confidence: 99%

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Deficiency of Act1, a critical modulator of B cell function, leads to development of Sjögren's syndrome

et al. 2008

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CD40L and B lymphocyte‐activating factor (BAFF), members of the TNF superfamily, play critical roles in B cell survival and activation, and in the regulation of humoral immunity. We previously reported that the adaptor molecule Act1 functions as a negative regulator of CD40‐ and BAFF‐mediated B cell survival. Here we demonstrated that mice deficient in Act1 developed systemic autoimmune disease with histological and serological features of human Sjögren's syndrome (SS), in association with systemic lupus erythematosus‐like nephritis. Analyses of Act1−/−CD40−/− and Act1−/−BAFF−/− double‐deficient mice revealed that Act1 regulates different stages of the disease development through its impact on both CD40‐ and BAFF‐mediated pathways. We found that Act1 modulates the survival of autoreactive B cells mainly through its negative regulatory role in BAFF‐mediated cell survival, while the effect of Act1 on autoantibody production is likely through modulation of CD40‐mediated T cell‐dependent antibody response. The impact of Act1 on both BAFF and CD40 pathways establishes Act1‐deficient mice as a unique model to study distinct steps of autoimmunity and regulation of self tolerance.

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“…The major autoantibodies associated with SS are rheumatoid factor, anti-Ro (SS-A), and anti-La (SS-B). Autoantibodies against salivary duct antigens are also found in the serum (2) and, recently, 95% of primary SS patients were reported to have serum antibodies against ␣ -fodrin. The role of these autoantibodies in disease pathogenesis is unclear, but tolerization with ␣ -fodrin prevented disease in a mouse model, suggesting an important role in disease development (3).…”

Section: Introductionmentioning

confidence: 99%

Antigen-driven clonal proliferation of B cells within the target tissue of an autoimmune disease. The salivary glands of patients with Sjögren's syndrome.

Stott¹,

Hiepe²,

Hummel³

et al. 1998

J. Clin. Invest.

312

286

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Occurrence of antibody to salivary duct epithelium in Sjogren's disease, rheumatoid arthritis, and other arthritides. A clinical and laboratory study.

Cited by 86 publications

References 30 publications

Renal Tubular Acidosis, Glomerulonephritis and Immunologic Factors in Sjogren's Syndrome

Renal Tubular Acidosis, Glomerulonephritis and Immunologic Factors in Sjogren's Syndrome

Deficiency of Act1, a critical modulator of B cell function, leads to development of Sjögren's syndrome

Antigen-driven clonal proliferation of B cells within the target tissue of an autoimmune disease. The salivary glands of patients with Sjögren's syndrome.

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