Occurrence of basal cell carcinoma among multiple trichoepitheliomas

Johnson, Sylvia C.; Bennett, Richard G.

doi:10.1016/0190-9622(93)70046-v

Cited by 63 publications

(39 citation statements)

References 11 publications

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“…For adnexal skin tumors such as TE, a gatekeeper function may be associated with the functioning of PTCH1, a receptor for hedgehog proteins, which is mutated in BCCs (16). Malignant changes (BCC) have been noted occasionally in cylindromas (36) and TEs (14,37). Experimentally induced BCC in mice tend to be associated with other hair follicle neoplasias such as trichoblastoma, TE, and cylindroma (32).…”

Section: Discussionmentioning

confidence: 99%

“…In some MFT tumors, structures reminiscent of basal cell carcinoma (BCC) may be found (14), although MFT clearly differs from Gorlin syndrome (multiple nevoid BCC syndrome) that is caused by mutations in the patched gene (PTCH1) on 9q22.3. In half of a series of sporadic TEs loss of heterozygosity (LOH) at 9q22.3, the region where PTCH1 maps was detected by Matt et al (15) who postulated a common gatekeeper mechanism for both TE and BCC.…”

Section: Introductionmentioning

confidence: 99%

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Multiple Familial Trichoepithelioma Caused by Mutations in the Cylindromatosis Tumor Suppressor Gene

Salhi

Bornholdt²,

Oeffner³

et al. 2004

Cancer Research

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The recessive oncogene cylindromatosis (CYLD) mapping on 16q12-q13 is generally implicated in familial cylindromatosis, whereas a gene region for multiple familial trichoepithelioma has been assigned to 9p21. Markers from both chromosome intervals were subjected to linkage analysis in a large family with multiple hereditary trichoepithelioma (TE) from Algeria. Linkage to 9p21 was excluded, whereas CYLD remained as a candidate. Mutation analysis identified a single bp germ-line deletion expected to result in truncation or absence of the encoded protein, which segregated with the multiple TE phenotype. In individual tumors, loss of heterozygosity at 16q or a somatic point mutation in the CYLD gene was detected. Hence, mutations of the tumor suppressor gene CYLD at 16q12-q13 may give rise to familial TE indistinguishable from the phenotype assigned to 9p21.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Multiple Familial Trichoepithelioma Caused by Mutations in the Cylindromatosis Tumor Suppressor Gene

Salhi

Bornholdt²,

Oeffner³

et al. 2004

Cancer Research

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“…[1][2][3] Cases of BCC associated with multiple trichoepitheliomas have been well documented, [4][5][6][7] and rare lesions with both the features of trichoblastoma and BCC can be observed histopathologically. [8][9] The existence of diagnostically confusing cases, whether trichoblastoma or BCC, [10][11][12] may be an expected event.…”

mentioning

confidence: 99%

Merkel Cell-Poor Trichoblastoma With Basal Cell Carcinoma-Like Foci

Misago

Satoh²,

Miura³

et al. 2007

The American Journal of Dermatopathology

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We reexamined 11 cases of trichoblastoma, and two cases of trichoblastoma with basal cell carcinoma (BCC)-like foci were found. In these two trichoblastomas with BCC-like foci, the BCC-like foci were often localized in peripheral or deep areas of lesions extending out of the fibrocytic stroma. Immunohistochemistry was performed in five conventional trichoblastomas and in two trichoblastomas with BCC-like foci, using antibodies against CK20 and CK15. No CK20-positive Merkel cells and no expression of CK15 were seen in any neoplastic aggregations of the two trichoblastomas with BCC-like foci. In contrast, increased numbers of Merkel cells and positive staining for CK15 were observed in all five trichoblastomas without BCC-like foci. The five trichoblastomas without BCC-like foci included two trichoblastomas with a popped out or shelled out appearance, which characteristically had a thick fibrous capsule surrounding the fibrotic stroma, demonstrating numerous Merkel cells in the aggregations. Some trichoblastomas may undergo mutations, resulting in the development of foci of BCC and in the loss of the expression of CK15 as well as the disappearance of Merkel cells.

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“…talık vaka serisinde, TE ile BHK'nin aynı lezyon içe-risinde görülebildiğini belirtmişlerdir ancak birbirinden bağımsız olarak mı ortaya çıktıkları yoksa BHK'nin TE'den mi farklılaştığı konusunda kesin sonuca varamamışlardır. 15 Matt ve ark. ise TE ile BHK'nin %48 oranında ortak tümör süpresör gen bozukluğuna sahip olduğunu bildirmişlerdir.…”

Section: Discussionunclassified

Eyelid Basal Cell Carcinoma After Trichoepithelioma: A Case Report

Kaya¹,

Katircioğlu²,

Şingar³

et al. 2019

Turkiye Klinikleri J Ophthalmol

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rikoepitelyoma (TE), kıl foliküllerinden köken alan, benign karekterli olduğu bilinen bir cilt tümördür.1 Daha önce farklı isimlerle de tarif edilen TE; nadir görülen ve etyolojisi tam olarak bilinmeyen ancak ailevi yatkınlık bulunabileceği bildirilen bir tümördür.2-4 Bu olguda amacımız; göz kapağında yer alan ve benign karakterli olduğu için çok önemsenmeyebilecek olan TE'nin, ileri dönemlerde bazal hücreli karsinomaya (BHK) dönüşebileceğini tartışmaktır. A An na ah ht ta ar r K Ke el li im me el le er r: : Karsinom,bazal hücre; trikoepitelyoma multipl ailesel; gözkapağı tümörleri

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Occurrence of basal cell carcinoma among multiple trichoepitheliomas

Cited by 63 publications

References 11 publications

Multiple Familial Trichoepithelioma Caused by Mutations in the Cylindromatosis Tumor Suppressor Gene

Multiple Familial Trichoepithelioma Caused by Mutations in the Cylindromatosis Tumor Suppressor Gene

Merkel Cell-Poor Trichoblastoma With Basal Cell Carcinoma-Like Foci

Eyelid Basal Cell Carcinoma After Trichoepithelioma: A Case Report

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