Occurrence of Beauvericin and Enniatins in Wheat Affected by
            <i>Fusarium avenaceum</i>
            Head Blight

Logrieco, A.; Rizzo, A.; Ferracane, Rosalia; Ritieni, Alberto

doi:10.1128/aem.68.1.82-85.2002

Cited by 224 publications

(117 citation statements)

References 15 publications

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“…The Finnish raw cereal samples contained also very low concentrations of BEA [15]. However, higher concentrations have been reported in Finnish grains [16].…”

Section: Resultsmentioning

confidence: 96%

Levels of mycotoxins and sample cytotoxicity of selected organic and conventional grain‐based products purchased from Finnish and Italian markets

Jestoi¹,

Somma

Kouva³

et al. 2004

Molecular Nutrition Food Res

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The contamination levels of 16 different Fusarium- and Aspergillus-mycotoxins were chemically determined from randomly selected organic and conventional grain-based products purchased from Finnish and Italian markets. The cytotoxicity of the samples was analyzed with an in vitro test using feline fetal lung cells. Overall, the concentrations of the mycotoxins studied were low in all of the samples. Enniatins B and B1 as well as deoxynivalenol were the most predominant mycotoxins in the samples, being present in 97%, 97%, and 90% of the samples, respectively. The geographical origin or the agricultural practice had no influence on the mycotoxin concentrations of the samples. The babyfoods included in the samples had significantly lower concentrations of mycotoxins than the other products with a mean total mycotoxin content of 47 microg/kg compared with 99 microg/kg for the other kinds of food. All the samples evoked toxicity in the in vitro test, but no correlation between cytotoxicity and the mycotoxin concentrations was observed.

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“…The Finnish raw cereal samples contained also very low concentrations of BEA [15]. However, higher concentrations have been reported in Finnish grains [16].…”

Section: Resultsmentioning

confidence: 96%

Levels of mycotoxins and sample cytotoxicity of selected organic and conventional grain‐based products purchased from Finnish and Italian markets

Jestoi¹,

Somma

Kouva³

et al. 2004

Molecular Nutrition Food Res

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“…ENNs and BEA, two secondary metabolites of the genus Fusarium, are worldwide contaminants of grain-based foodstuff [29]. Especially in Norwegian and Finnish grain samples, a high prevalence of ENNs and BEA was shown with a maximum concentration of 18 300 ppb for ENN B in the year 2001 [30].…”

Section: Discussionmentioning

confidence: 96%

Interactions between ABC‐transport proteins and the secondary Fusarium metabolites enniatin and beauvericin

Dornetshuber

Heffeter

Sulyok³

et al. 2009

Molecular Nutrition Food Res

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Enniatins (ENN) and beauvericin (BEA) exert cytotoxic properties. Here, we observed that their impact on Ca(2+)-homeostasis can be reversed by exogenous ATP. Thus, we investigated whether membrane-located ATP-binding cassette (ABC) transporters influence ENNs- and BEA-induced cytotoxicity. In short-term exposure assays breast cancer resistance protein (ABCG2)-overexpression weakly but significantly reduced the cytotoxic activity of BEA but not ENNs. In contrast, multidrug resistance-associated protein-1 (ABCC1)- and P-glycoprotein (ABCB1)-overexpression was not protective under identical conditions. ABCG2-mediated resistance against BEA was reversible by ABCG2 modulators. In long-term exposure assays, ABCG2 and ABCB1 significantly protected against ENNs- and to a lesser extent BEA-induced cytotoxicity. Moreover, both fusariotoxins potently inhibited the ABCG2- and ABCB1-mediated efflux of specific fluorescent substrates, with BEA being more effective. Additionally, ATPase and photoaffinity-labelling assays proofed interaction of both substances with ABCG2 and ABCB1. Remarkably, 2 years selection of KB-3-1 cells against both fusariotoxins resulted only in two-fold ENNs but negligible BEA resistance. Interestingly, the selected sublines displayed upregulation of multidrug resistance proteins and crossresistance to other chemotherapeutics. Summarizing, ABCG2 and ABCB1 slightly but significantly protect human cells against ENNs- and BEA-induced cytotoxicity. However, both mycotoxins potently interact with ABCB1 and ABCG2 transport functions suggesting influences on bioavailability of xenobiotics and pharmaceuticals.

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“…[10][11][12] While beauvericin is produced as the sole cyclohexadepsipeptide metabolite by the former entomopathogenic fungi, it is often co-produced as a minor constituent with the structurally related enniatins by Fusarium species. [13][14][15][16] Recently we reported that Isaria tenuipes, a specific pathogen of Lepidoptera pupa or larva, and several phylogenetically closely related species constantly produce beauvericin when fermented in potato dextrose broth (PDB). 17 Isaria tenuipes has been used as folk medicines or health food, for good health, in East Asian countries, Japan, China, and South Korea.…”

Section: Introductionmentioning

confidence: 99%

Beauvericin production by the Lepidoptera pathogenic fungus Isaria tenuipes: Analysis of natural specimens, synnemata from cultivation, and mycelia from liquid-media fermentation

Supothina

Srisanoh

Nithithanasilp

et al. 2011

Nat. Prod. Bioprospect.

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Beauvericin was analyzed in three forms of the Lepidoptra pathogenic fungus Isaria tenuipes (4 isolates): (a) natural specimen, (b) cultivated synnemata on rice media, and (c) mycelia from fermentation in liquid media. Beauvericin was detected in very low amounts in all tested natural specimens. Synnemata on rice contained much higher concentrations of beauvericin than the corresponding natural materials, although the concentrations were lower than mycelia from liquid fermentation. The results casted a caution that beauvericin concentration should be carefully checked, as a possible toxic constituent, upon mass production of a selected strain of Isaria tenuipes for health food purposes.

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Occurrence of Beauvericin and Enniatins in Wheat Affected by Fusarium avenaceum Head Blight

Cited by 224 publications

References 15 publications

Levels of mycotoxins and sample cytotoxicity of selected organic and conventional grain‐based products purchased from Finnish and Italian markets

Levels of mycotoxins and sample cytotoxicity of selected organic and conventional grain‐based products purchased from Finnish and Italian markets

Interactions between ABC‐transport proteins and the secondary Fusarium metabolites enniatin and beauvericin

Beauvericin production by the Lepidoptera pathogenic fungus Isaria tenuipes: Analysis of natural specimens, synnemata from cultivation, and mycelia from liquid-media fermentation

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