Occurrence of bombesin and alytesin in extracts of the skin of three European discoglossid frogs and pharmacological actions of bombesin on extravascular smooth muscle

Erspamer, V.; Erspamer, G. Falconieri; Inselvini, M; Negri, Lucia

doi:10.1111/j.1476-5381.1972.tb08087.x

Cited by 131 publications

(38 citation statements)

References 10 publications

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“…The bombesin family of peptides received their unusual name because bombesin (Bn) and most of the subsequent other invertebrate members of this family were originally isolated from frog skins and they were named after the genus of the frog [1,2,3••] they were isolated from (i.e.…”

Section: Introductionmentioning

confidence: 99%

Bombesin-related peptides and their receptors: recent advances in their role in physiology and disease states

González

Moody

Igarashi

et al. 2008

Current Opinion in Endocrinology, Diabetes &Amp; Obesity

187

175

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Purpose of review-Mammalian bombesin-related peptides, gastrin-releasing peptide(GRP) and neuromedin B(NMB) actions are mediated by two receptors (BB 1 -,BB 2 -receptor), which are closely related to the orphan receptor BRS-3(BB 3 -receptor).The purpose of this review is to highlight advances in the understanding of these peptides in physiology/disease states.Recent Findings-Pharmacologic/receptor-knockout studies showinvolvement of these receptors in a number of new processes/diseases. NMB/BB 1 -receptor is an important physiological regulator of pituitary-thyroid function; in mediating behavior, especially fear/anxiety; in mediating satiety through different cascades than GRP/BB 2 receptors and for its autocrine tumor-growth effects. GRP/ BB 2 -receptor plays important roles in: mediating signals for pruritus; lung development/injury; small intestinal mucosal defense and CNS processes such as learning/memory. The signaling mechanisms of its potent growth effects are being elucidate and possible therapeutic targets identified. BB 3 -receptor knockout mice provided insights for their obesity/glucose intolerance and demonstrate this receptor may be important in the lung response to injury, tumor growth and GI motility. Each receptor is frequently over-expressed in human tumors and have potent growth effects. This effect is being explored to develop new anti-tumor treatments, such as Bn-receptor ligands conjugated to cytotoxic agents.Summary-This receptor family are involved in an increasing number of CNS/peripheral processes physiologically and in disease states, and increased understanding of their role may lead to novel treatments, especially for pruritus, CNS disorders, lung diseases and tumor localization/treatment.

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Section: Introductionmentioning

confidence: 99%

Bombesin-related peptides and their receptors: recent advances in their role in physiology and disease states

González

Moody

Igarashi

et al. 2008

Current Opinion in Endocrinology, Diabetes &Amp; Obesity

187

175

View full text Add to dashboard Cite

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“…Bombesin, the tetradecapeptide occurring in the skin of the European discoglossid frogs Bombina bombina and Bombina variegata variegata has been shown to act on several isolated and in situ smooth muscle preparations, on the systemic blood pressure of some common laboratory animals and on the kidney of the anaesthetized dog (Erspamer, Falconieri Erspamer, Negri & Inselvini, 1972;Erspamer, Melchiorri & Sopranzi, 1972.…”

Section: Introductionmentioning

confidence: 99%

The actions of bombesin on gastric secretion of the dog and the rat

Bertaccini

Erspamer

Impicciatore

1973

British J Pharmacology

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Summary1. Bombesin stimulated acid secretion from the denervated fundic pouch of the dog. Whereas the concentration of hydrochloric acid in bombesin-produced juice was always higher than in control juice this did not occur for pepsin, the concentration of which remained below the basal values. The threshold dose of bombesin was 5-30 ng/kg by the subcutaneous route and 0-05-0-2 (gg/kg)/h by intravenous infusion. At low doses bombesin was more active than caerulein, even on a molar basis, and at high dose levels was as active as caerulein. In contrast to gastrin and caerulein, bombesin elicited a moderate secretory response also following rapid intravenous injection.2. The acid secretion provoked by bombesin was almost completely inhibited by atropine and reduced by approximately 50% by hexamethonium. 3. Bombesin did not stimulate acid secretion in the lumen-perfused preparation of the rat stomach when administered by subcutaneous injection (up to 10

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“…The methods employed were identical to those described in detail in earlier papers (Erspamer, Falconieri Erspamer, Inselvini & Negri, 1972a …”

Section: Methodsmentioning

confidence: 99%

PARALLEL BIOASSAY OF BOMBESIN AND LITORIN, A BOMBESIN‐LIKE PEPTIDE FROM THE SKIN OF Litoria aurea

Endean¹,

Erspamer²,

Erspamer³

et al. 1975

British J Pharmacology

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The spectrum of biological activity exhibited by litorin, a bombesin‐like nonapeptide found in extracts of the skin of the Australian leptodactylid frog Litoria aurea was compared with that exhibited by the tetradecapeptide bombesin. Litorin proved to be more potent than bombesin on isolated smooth muscle preparations and on the urinary bladder in situ. However, it was less potent on dog systemic blood pressure and kidney vasculature, activation of the renin‐angiotensin system being slight or lacking. Gastrin release and acid secretion produced by litorin was more rapid in onset but less intense and less sustained than that elicited by bombesin. The same could be observed for pancreatic secretion. Gall bladder contraction stimulated by litorin was probably caused by a double action of the peptide, directly on the bladder smooth muscle, and indirectly by cholecystokinin release. In its effects on the myo‐electric activity of the dog duodenum (inhibition of spikes and increase in frequency of pacesetter potentials leading to the appearance of a sequence of slow and small potentials) litorin possessed approximately 50 to 70% of the activity of bombesin.

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Occurrence of bombesin and alytesin in extracts of the skin of three European discoglossid frogs and pharmacological actions of bombesin on extravascular smooth muscle

Cited by 131 publications

References 10 publications

Bombesin-related peptides and their receptors: recent advances in their role in physiology and disease states

Bombesin-related peptides and their receptors: recent advances in their role in physiology and disease states

The actions of bombesin on gastric secretion of the dog and the rat

PARALLEL BIOASSAY OF BOMBESIN AND LITORIN, A BOMBESIN‐LIKE PEPTIDE FROM THE SKIN OF Litoria aurea

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