Occurrence of caffeine in the freshwater environment: Implications for ecopharmacovigilance

Li, Shulan; Wen, Jing; He, Bingshu; Wang, Jun; Hu, Xianmin; Liu, Juan

doi:10.1016/j.envpol.2020.114371

Cited by 91 publications

(34 citation statements)

References 165 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Tarazona et al [24] have paid attention to unprecedent levels of emissions of antiviral medicinal products as potential treatment for COVID-19 to the aquatic environment, and proposed the environmental impact assessment should be strengthened and improved. Ecopharmacovigilance (EPV) is a kind of pharmacovigilance for the environment, and has been considered as an effective drug administration route on environment pollution caused by PECs [11] , [12] , [27] , [8] . The concept of EPV involves the detection, assessment, understanding and prevention of adverse effects or other problems associated with the presence of PECs in the environment.…”

Section: Introductionmentioning

confidence: 99%

“…The concept of EPV involves the detection, assessment, understanding and prevention of adverse effects or other problems associated with the presence of PECs in the environment. Being different from the efforts made by environmental experts for the removal of PECs from environmental matrices, EPV emphasizes the upstream control of PEC sources and related anthropogenic behaviours to constrain the environmental discharge of PECs, thus has been believed as a more fundamental, economical and feasible solution for PEC pollution in the environment [11] , [12] , [27] , [28] . So far, the well-accepted practice approaches to EPV include: promoting rational use of drugs, in particular, implementing eco-directed sustainable drug prescribing and dispensing practices to reduce the environmental footprints of PECs from the patients' excretion; improving pharmacy take-back programs and safe management strategies for expired and unused medicines; well-controlling the emissions from pharmaceutical manufacturing and hospitals; as well as accelerating the design and process development of green drugs, etc.…”

Section: Introductionmentioning

confidence: 99%

“…So far, the well-accepted practice approaches to EPV include: promoting rational use of drugs, in particular, implementing eco-directed sustainable drug prescribing and dispensing practices to reduce the environmental footprints of PECs from the patients' excretion; improving pharmacy take-back programs and safe management strategies for expired and unused medicines; well-controlling the emissions from pharmaceutical manufacturing and hospitals; as well as accelerating the design and process development of green drugs, etc. Wang et al, ($year$) [11] , [12] , [26] , [27] , [28] …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Impact of the COVID-19 pandemic on household disinfectant consumption behaviors and related environmental concerns: A questionnaire-based survey in China

Guo

Liao

et al. 2021

Journal of Environmental Chemical Engineering

Self Cite

View full text Add to dashboard Cite

Considering the potential hazardous effects of disinfectant residues on environment, organisms and biodiversity, the sharp rise in use of disinfectants during COVID-19 pandemic has been considered highly likely to cause worldwide secondary disasters in ecosystems and human health. This questionnaire-based survey investigated the impact of COVID-19 outbreak on household disinfectant product consumption levels and behaviour of 3667 Chinese residents. In particular, in the context that no strategy is currently available to minimize the disinfectant pollution, based on the similarities between disinfectants and pharmaceuticals, we proposed a perspective of ecopharmacovigilance (EPV), which is an effective measure to minimize the environmental risks posed by pharmaceuticals using drug administration protocols, for disinfectant environmental risk management. The public’s environmental perceptions, attitudes and the related practices regarding household disinfectant consumption from an EPV perspective were also included in the study. The results showed that the COVID-19 outbreak caused a tremendous rise in the public’s household disinfectant consumption and usage levels in China. After the COVID-19 outbreak, the chlorine-based and alcohol-based disinfectants were considered as the most preferred products for household disinfection and hand sanitization, respectively. Importantly, the Chinese public’s environmental perceptions and practice on disinfectants were poor. Less than half respondents had positive attitudes toward the source control of disinfectant pollution. The population groups including females, the middle aged adults, those having healthcare professional background, as well as the higher-educated could be focused on to develop targeted efforts for the future control of disinfectant pollution in environment.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Impact of the COVID-19 pandemic on household disinfectant consumption behaviors and related environmental concerns: A questionnaire-based survey in China

Guo

Liao

et al. 2021

Journal of Environmental Chemical Engineering

Self Cite

View full text Add to dashboard Cite

show abstract

“…Likewise, other types of natural compounds emitted primarily by the anthroposphere, such as food ingredients and personal care products, as well as human hormones are equally present in surface and groundwaters. Thus, caffeine, nicotine, estrogens, piperine, steroids and morphine occur frequently in screening studies of surface and groundwaters, e.g., [23][24][25][26][27].…”

Section: They Make It To the Watermentioning

confidence: 99%

Natural toxins: environmental contaminants calling for attention

2021

View full text Add to dashboard Cite

Biosynthetic toxic compounds from plants and cyanobacteria constitute a chemically diverse family of at least 20,000 compounds. Recent work with natural toxin databases and toxin characterization shows that the majority of natural toxins are polar and mobile, with toxicity ranging from low to very high, while persistence is highly variable. Natural toxins may be produced in high quantities—some exceeding 10 g/m2/year—resulting in high environmental loads. Recent phytotoxin monitoring indicates that one or more natural toxin is always present in a surface water sample, but that concentrations are highly variable often with pulses during rain events. Phytotoxins belong to many classes, but often with flavonoids and alkaloids dominating. Likewise, advanced monitoring discovers a wide spectrum of cyanobacterial metabolites that are released directly into surface waters during water blooms. Except of the few known cyanobacterial toxins, we have very limited info regarding their environmental fate and toxicity.The 16 papers in this article collection present examples of natural toxin occurrence, properties, fate and toxicity. The overarching conclusion is that natural toxins should be monitored and characterized regarding their risk potential, and that natural toxins of greatest expected risk should be evaluated as thoroughly as industrial xenobiotics. Cyanotoxins are well known water contaminants that should be removed for producing drinking water, while for phytotoxins the current knowledge base is very limited. We advocate to intensify research on natural toxins, and to address the evident knowledge gaps on natural toxin analysis/monitoring, physical–chemical properties and degradation/pathways, transport modelling, and toxicity. The complex and dynamic interplays between biotic and site conditions such as vegetation, toxic plant densities, climate, soil types, nutrients and radiation, play decisive roles for both biotoxin formation and fate. Environmental and toxicological research in biosynthesized compounds extends beyond natural toxins, with important perspectives for risk assessment of biopesticides, growth regulators and biomedicine (or biologicals collectively) produced by plants and microorganisms.

show abstract

“…In 2015, PD affected constituent or as an additive in many different food products, beverages, and medicines [6][7][8]. The occurrence of CA has also been reported in natural water [9,10]. Currently, CA is the most widely used psychotropic substance in the world [11].…”

Section: Introductionmentioning

confidence: 99%

Detection of caffeine and its main metabolites for early diagnosis of Parkinson's disease using micellar electrokinetic capillary chromatography

et al. 2020

View full text Add to dashboard Cite

Caffeine (CA) is a common xanthine alkaloid found in tea leaves, coffee beans, and other natural plants, and is the most widely used psychotropic substance in the world. Accumulating evidence suggests that low plasma levels of CA and its metabolites may serve as reliable diagnostic markers for early Parkinson's disease (PD) patients. In this study, we demonstrated a new MEKC method for determining CA and its three main downstream metabolites, paraxanthine (PX), theobromine (TB), and theophylline (TP), in human plasma. Plasma samples were collected, and analyzed using MEKC, after SPE. The running buffer was composed of 35 mM phosphate, pH of 10.5, and 25 mM SDS. The separation voltage was 15 kV and the detection wavelength was at 210 nm. Under the optimum conditions, four distinct analytes were completely separated and detected in less than 12 min. Method limits of detection were as low as 7.5 ng/mL for CA, 5.0 ng/mL for TB, and 4.0 ng/mL for both PX and TP. The recoveries were between 88.0% and 105.9%. This method was successfully applied to 27 human plasma samples. The results indicate that the plasma concentrations of the four analytes are significantly lower in patients with early PD than in control subjects (p < 0.05). The area under curve was improved to 0.839 when CA and its three main metabolites were included, suggesting that MEKC testing of CA, TP, TB, and PX may serve as a potential method for early diagnosis of PD.

show abstract

Occurrence of caffeine in the freshwater environment: Implications for ecopharmacovigilance

Cited by 91 publications

References 165 publications

Impact of the COVID-19 pandemic on household disinfectant consumption behaviors and related environmental concerns: A questionnaire-based survey in China

Impact of the COVID-19 pandemic on household disinfectant consumption behaviors and related environmental concerns: A questionnaire-based survey in China

Natural toxins: environmental contaminants calling for attention

Detection of caffeine and its main metabolites for early diagnosis of Parkinson's disease using micellar electrokinetic capillary chromatography

Contact Info

Product

Resources

About