Occurrence of chloramphenicol in cereal straw in north-western Europe

Nordkvist, Erik; Zuidema, T.; Herbes, Rik; Berendsen, B.J.A.

doi:10.1080/19440049.2016.1176450

Cited by 16 publications

(9 citation statements)

References 6 publications

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“…Interestingly, although banned for use in food-producing animals in many countries (since 1994 in Europe; [ 98 ]), decreased chloramphenicol susceptibility continues to be described, not only in the present study (with MIC of 32 to > 64 mg/l), but also in others, with the presence of cat genes [ 87 , 99 ]. Chloramphenicol can occur naturally, produced by soil organisms such as Streptomyces venezuelae .…”

Section: Discussionmentioning

confidence: 52%

“…Chloramphenicol can occur naturally, produced by soil organisms such as Streptomyces venezuelae . The persistence of decreased susceptibility to this antibiotic may be due to intrinsic mechanisms of resistance as possibly in P. putida and P. stutzeri from our study or co-selection with other antibiotics and/or heavy metals [ 98 , 100 , 101 ]. On the other hand, florfenicol is widely used in aquaculture [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

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Bacterial Diversity and Antibiotic Susceptibility of Sparus aurata from Aquaculture

et al. 2020

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In a world where the population continues to increase and the volume of fishing catches stagnates or even falls, the aquaculture sector has great growth potential. This study aimed to contribute to the depth of knowledge of the diversity of bacterial species found in Sparus aurata collected from a fish farm and to understand which profiles of diminished susceptibility to antibiotics would be found in these bacteria that might be disseminated in the environment. One hundred thirty-six bacterial strains were recovered from the S. aurata samples. These strains belonged to Bacillaceae, Bacillales Family XII. Incertae Sedis, Comamonadaceae, Enterobacteriaceae, Enterococcaceae, Erwiniaceae, Micrococcaceae, Pseudomonadaceae and Staphylococcaceae families. Enterobacter sp. was more frequently found in gills, intestine and skin groups than in muscle groups (p ≤ 0.01). Antibiotic susceptibility tests found that non-susceptibility to phenicols was significantly higher in gills, intestine and skin samples (45%) than in muscle samples (24%) (p ≤ 0.01) and was the most frequently found non-susceptibility in both groups of samples. The group of Enterobacteriaceae from muscles presented less decreased susceptibility to florfenicol (44%) than in the group of gills, intestine and skin samples (76%). We found decreased susceptibilities to β-lactams and glycopeptides in the Bacillaceae family, to quinolones and mupirocin in the Staphylococcaceae family, and mostly to β-lactams, phenicols and quinolones in the Enterobacteriaceae and Pseudomonadaceae families. Seven Enterobacter spp. and five Pseudomonas spp. strains showed non-susceptibility to ertapenem and meropenem, respectively, which is of concern because they are antibiotics used as a last resort in serious clinical infections. To our knowledge, this is the first description of species Exiguobacterium acetylicum, Klebsiella michiganensis, Lelliottia sp. and Pantoea vagans associated with S. aurata (excluding cases where these bacteria are used as probiotics) and of plasmid-mediated quinolone resistance qnrB19-producing Leclercia adecarboxylata strain. The non-synonymous G385T and C402A mutations at parC gene (within quinolone resistance-determining regions) were also identified in a Klebsiella pneumoniae, revealing decreased susceptibility to ciprofloxacin. In this study, we found not only bacteria from the natural microbiota of fish but also pathogenic bacteria associated with fish and humans. Several antibiotics for which decreased susceptibility was found here are integrated into the World Health Organization list of “critically important antimicrobials” and “highly important antimicrobials” for human medicine.

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Section: Discussionmentioning

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Bacterial Diversity and Antibiotic Susceptibility of Sparus aurata from Aquaculture

et al. 2020

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“…Chlooramfenicol wordt geproduceerd door bodembacteriën (onder andere door Streptomyces venezuela) en komt daardoor mogelijk ook via een natuurlijke route in de diervoederketen. Een studie met maïs en tarwe heeft aangetoond dat chlooramfenicol door planten wordt opgenomen (Berendsen et al, 2013a), wat verklaart dat chlooramfenicol veelvuldig in producten als stro wordt aangetroffen (Nordkvist et al, 2016). Gevonden gehalten liggen over het algemeen op een laag (zelfs sub µg/kg) niveau, met uitschieters tot 32 µg/kg (Nordkvist et al, 2016).…”

Section: Algemeenunclassified

“…Een studie met maïs en tarwe heeft aangetoond dat chlooramfenicol door planten wordt opgenomen (Berendsen et al, 2013a), wat verklaart dat chlooramfenicol veelvuldig in producten als stro wordt aangetroffen (Nordkvist et al, 2016). Gevonden gehalten liggen over het algemeen op een laag (zelfs sub µg/kg) niveau, met uitschieters tot 32 µg/kg (Nordkvist et al, 2016). Het is tot dusver onduidelijk in welke mate er vanuit deze voedermatrix overdracht naar dieren plaatsvindt.…”

Section: Algemeenunclassified

Chemische en fysische gevaren in de Nederlandse diervoederketen

Fels‐Klerx¹,

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Adamse

et al. 2019

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“…These results suggest that CAP residues in the food chain would cause food safety problems that could seriously harm human health 5–7 . Therefore, in many countries and regions, CAP is prohibited in poultry farming to prevent it entering the food chain 8, 9 . However, due to its low cost and high efficiency, illegal use of CAP has always taken place, 10–12 so monitoring animal tissues and foods for CAP residue is of great significance for human health.…”

Section: Introductionmentioning

confidence: 99%

A simple and sensitive flow injection chemiluminescence immunoassay for chloramphenicol based on gold nanoparticle‐loaded enzyme

et al. 2020

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A simple and ultrasensitive flow injection chemiluminescence competitive immunoassay based on gold nanoparticle‐loaded enzyme for the detection of chloramphenicol (CAP) residues in shrimp and honey has been developed. Due to their good biocompatibility and large specific surface area, carboxylic resin beads can be used as solid phase carriers to immobilize more coating antigens (Ag). In addition, gold nanoparticles could provide an effective matrix for loading more CAP antibody and horseradish peroxidase, which would effectively catalyze the system of luminol–p‐iodophenol (PIP)–H2O2. A competitive immunoassay strategy was used for detection of CAP, in which CAP in the sample would compete with the coating Ag for the limited antibodies, leading to a chemiluminescence (CL) signal decrease with increase in CAP concentration. A wide linear range 0.001–10 ng ml−1 (R2 = 0.9961) was obtained under optimized conditions, and the detection limit (3σ) was calculated to be 0.33 pg ml−1. This method was also been successfully applied to determine CAP in shrimp and honey samples. The immunosensor proposed in this study not only has the advantages of high sensitivity, wider linear range, and satisfactory stability, but also expands the application of flow injection CL immunoassay in antibiotic detection.

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Occurrence of chloramphenicol in cereal straw in north-western Europe

Cited by 16 publications

References 6 publications

Bacterial Diversity and Antibiotic Susceptibility of Sparus aurata from Aquaculture

Bacterial Diversity and Antibiotic Susceptibility of Sparus aurata from Aquaculture

Chemische en fysische gevaren in de Nederlandse diervoederketen

A simple and sensitive flow injection chemiluminescence immunoassay for chloramphenicol based on gold nanoparticle‐loaded enzyme

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