Occurrence of Crohn's disease with Parkinson’s disease

Fujioka, Shinsuke; Curry, Sadie; Kennelly, Kathleen D.; Tacik, Paweł; Heckman, Michael G.; Tsuboi, Yoshio; Strongosky, Audrey; Gerpen, Jay A. van; Uitti, Ryan J.; Ross, Owen A.; Ikezu, Tsuneya; Wszołek, Zbigniew K.

doi:10.1016/j.parkreldis.2017.01.013

Cited by 27 publications

(15 citation statements)

References 5 publications

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“…Another retrospective study by Fujioka et al investigated the occurrence of CD with PD by searching the medical records of 876 PD patients and subsequently looked for incidences of prior or cur-rent CD. The study found that the co-occurrence of CD with PD was consistent with the number of cases expected in the general population [61]. However, limitations to this study was the relatively small number of subjects.…”

Section: Epidemiological Evidence For a Link Between Ibd And Pdsupporting

confidence: 82%

Inflammatory Bowel Diseases and Parkinson’s Disease

Brudek

2019

JPD

107

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The etiology of Parkinson's disease (PD) is multifactorial, with genetics, aging, and environmental agents all a part of the PD pathogenesis. Widespread aggregation of the ␣-synuclein protein in the form of Lewy bodies and Lewy neurites, and degeneration of substantia nigra dopamine neurons are the pathological hallmarks of PD. Inflammatory responses manifested by glial reactions, T cell infiltration, and increased expression of inflammatory cytokines, as well as other toxic mediators derived from activated glial cells, are currently recognized as prominent features of PD. Experimental, clinical and epidemiological data suggest that intestinal inflammation contributes to the pathogenesis of PD, and the increasing number of studies suggests that the condition may start in the gastrointestinal system years before any motor symptoms develop. Patients with inflammatory bowel disease (IBD) have a higher risk of developing PD compared with non-IBD individuals. Gene association study has found a genetic link between IBD and PD, and an evidence from animal studies suggests that gut inflammation, similar to that observed in IBD, may induce loss of dopaminergic neurons. Based on preclinical models of PD, it is suggested that the enteric microbiome changes early in PD, and gut infections trigger ␣-synuclein release and aggregation. In this paper, the possible link between IBD and PD is reviewed based on the available literature. Given the potentially critical role of gastrointestinal pathology in PD pathogenesis, there is reason to suspect that IBD or its treatments may impact PD risk. Thus, clinicians should be aware of PD symptoms in IBD patients.

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Section: Epidemiological Evidence For a Link Between Ibd And Pdsupporting

confidence: 82%

Inflammatory Bowel Diseases and Parkinson’s Disease

Brudek

2019

JPD

107

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“…In the Swedish study, patients with IBD who did not receive treatment were 60% more likely to develop PD than their matched controls, whereas treated IBD patients had a nonsignificantly decreased risk of developing PD compared to nontreated patients [89]. However, a retrospective study enrolling 876 patients with PD identified only 2 patients with CD prior to the PD diagnosis, an incidence similar to that in the general population [91]. Another large population-based, case–control study enrolling patients aged 65 years or older with newly diagnosed PD ( n = 89,790) and controls ( n = 118,095) identified an inverse correlation between PD and IBD, suggesting that patients with IBD are less likely to develop PD [90].…”

Section: Mechanism Of Gi Impairment and Gut Pathology In Pdmentioning

confidence: 99%

Altered Gut Microbiome and Intestinal Pathology in Parkinson’s Disease

Chiang

Lin

2019

JMD

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Parkinson’s disease (PD) is a common neurodegenerative disorder arising from an interplay between genetic and environmental risk factors. Studies have suggested that the pathological hallmarks of intraneuronal α-synuclein aggregations may start from the olfactory bulb and the enteric nervous system of the gut and later propagate to the brain via the olfactory tract and the vagus nerve. This hypothesis correlates well with clinical symptoms, such as constipation, that may develop up to 20 years before the onset of PD motor symptoms. Recent interest in the gut–brain axis has led to vigorous research into the gastrointestinal pathology and gut microbiota changes in patients with PD. In this review, we provide current clinical and pathological evidence of gut involvement in PD by summarizing the changes in gut microbiota composition and gut inflammation associated with its pathogenesis.

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“…Nothing has been published on this subject for the next 20 years but the genetic overlap between PD and CD relaunched the debate. While a small monocentric retrospective study did not observe any increased occurrence of CD in PD patients [11], four large nationwide surveys showed that IBD patients had an increased risk of subsequent PD compared to controls [12][13][14][15] ( table 1). After combining the data of these four studies, a recent meta-analysis showed that the overall risk of PD in IBD was significantly higher than controls (relative risk 1.41, 95% confidence interval:…”

Section: Pd and Ibd Are Epidemiologically Linkedmentioning

confidence: 99%

Is Parkinson’s disease a chronic low-grade inflammatory bowel disease?

et al. 2019

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While the pathogenesis of Parkinson's disease is not fully understood, there is increasing evidence that inflammatory responses in the brain are implicated in both disease initiation and progression. The inflammatory process in Parkinson's disease is however not limited to the brain but also involves the gastrointestinal tract. High amounts of cytokines and inflammatory markers are found in the colon of Parkinson's disease patients and there is now strong epidemiological and genetical evidence linking Parkinson's disease to inflammatory bowel diseases. Recent findings obtained in both experimental inflammatory bowel diseases and Parkinson's disease further support a bidirectional link between gastrointestinal inflammation and brain neurodegeneration. Altogether these observations suggest a role for gastrointestinal inflammation in the initiation and progression of Parkinson's disease.

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Occurrence of Crohn's disease with Parkinson’s disease

Cited by 27 publications

References 5 publications

Inflammatory Bowel Diseases and Parkinson’s Disease

Inflammatory Bowel Diseases and Parkinson’s Disease

Altered Gut Microbiome and Intestinal Pathology in Parkinson’s Disease

Is Parkinson’s disease a chronic low-grade inflammatory bowel disease?

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