Occurrence of Cystic Fibrosis Transmembrane Conductance Regulator Gene Mutations in Patients with Allergic Bronchopulmonary Aspergillosis Complicating Asthma

Kanaujia, Rimjhim; Arora, Amit; Chakrabarti, Arunaloke; Rudramurthy, Shivaprakash M; Agarwal, Ritesh

doi:10.1007/s11046-022-00631-y

Cited by 8 publications

(4 citation statements)

References 43 publications

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“…However, another important possibility must be considered, particularly in countries where cystic fibrosis is uncommon [64,65]. A recent study from adult asthmatics found a higher frequency of single nucleotide polymorphisms (SNPs) in the CFTR gene among ABPA, complicating asthma compared to asthmatics and healthy controls [66]. ABPA is also regarded as a cystic fibrosis transmembrane conductance regulator (CFTR)related disease [67,68], and the latter may be more relevant in children than adults.…”

Section: Discussionmentioning

confidence: 99%

Aspergillus Sensitization and Allergic Bronchopulmonary Aspergillosis in Asthmatic Children: A Systematic Review and Meta-Analysis

et al. 2023

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Background: The prevalence of aspergillus sensitization (AS) and allergic bronchopulmonary aspergillosis (ABPA) in asthmatic children remains unclear. Objective: To systematically review the literature to estimate the prevalence of AS and ABPA in children with bronchial asthma. Methods: We searched the PubMed and Embase databases for studies reporting the prevalence of AS or ABPA in pediatric asthma. The primary outcome was to assess the prevalence of AS, while the secondary outcome was to evaluate the prevalence of ABPA. We pooled the prevalence estimates using a random effects model. We also calculated the heterogeneity and publication bias. Results: Of the 11,695 records retrieved, 16 studies with 2468 asthmatic children met the inclusion criteria. Most studies were published from tertiary centers. The pooled prevalence of AS in asthma (15 studies; 2361 subjects) was 16.1% (95% confidence intervals [CI], 9.3–24.3). The prevalence of AS was significantly higher in prospective studies, studies from India, and those from developing countries. The pooled prevalence of ABPA in asthma (5 studies; 505 children) was 9.9% (95% CI, 0.81–27.6). There was significant heterogeneity and publication bias for both outcomes. Conclusions: We found a high prevalence of AS and ABPA in asthmatic children. There is a need for community-based studies from different ethnicities using a standard methodology to ascertain the true prevalence of AS and ABPA in pediatric asthma.

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Section: Discussionmentioning

confidence: 99%

Aspergillus Sensitization and Allergic Bronchopulmonary Aspergillosis in Asthmatic Children: A Systematic Review and Meta-Analysis

et al. 2023

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“…47 However, only a few studies have evaluated genetic association in Indian ABPA patients (Table 2). [48][49][50] Not only are these studies limited by their small sample size, but also they have evaluated the association between polymorphisms in surfactant protein A2, mannose-binding lectin, and CFTR gene only. Large studies are needed to explore the host susceptibility factors in Indian ABPA patients.…”

Section: Ta B L E 1 (Continued)mentioning

confidence: 99%

Allergic bronchopulmonary aspergillosis in India

Agarwal

Sehgal

Muthu

et al. 2023

Clin Experimental Allergy

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Allergic bronchopulmonary aspergillosis (ABPA) is a lung disorder caused by immune‐mediated reactions mounted against Aspergillus fumigatus. The disorder most commonly complicates the course of patients with asthma and cystic fibrosis. From its first description in 1952, significant advances have been made in understanding the pathogenesis and the diagnosis and treatment of ABPA. In the last two decades, most research on ABPA has been published from India. The prevalence and clinical presentation may differ in India from that reported elsewhere. Herein, we review the epidemiology, clinical and radiological characteristics, and distinctive features of ABPA in the Indian subcontinent. To support the review, we surveyed pulmonologists nationwide to understand the challenges in diagnosing and managing ABPA. The survey has yielded valuable insights into the practices associated with the diagnosis and management of ABPA in India.

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“…Genetic polymorphisms in proteins related to barrier homeostasis, such as surfactant protein A2, CFTR, or mannose-binding lectin, have been found in ABPA patients [7]. That genetic background might contribute to generate a physical and functional predisposing condition to aberrant immune responses to fungi.…”

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Epidemiology of the relationship between allergic bronchopulmonary aspergillosis and asthma

Maule,

Vitte,

Ambrosani

et al. 2024

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of review Allergic bronchopulmonary aspergillosis (ABPA) can complicate the natural history of asthmatic patients, especially the more severe ones, worsening disease control and increasing the need for therapies, steroids in particular, and medical care. The aim of the present review is to summarize the latest epidemiological data related to the relationship between asthma and ABPA and to offer a summary of the most recent strategies that could potentially facilitate in the identification of ABPA in asthmatic patients. Recent findings In the last years, great efforts have been made by researchers worldwide to provide reliable epidemiological data on fungal sensitization and ABPA, especially in severe asthma patients both in adult and pediatric population. Data differ depending on the geographical area and population studied, but pooled data show a concerning 11% of severe asthma patients having ABPA and one out of four asthmatic patients being sensitized to fungi, Aspergillus fumigatus in particular. Summary Reliable epidemiological data and advances in the diagnostic procedures can facilitate the detection of ABPA among asthmatic patients, improving the management of a still under-recognized and challenging condition.

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Occurrence of Cystic Fibrosis Transmembrane Conductance Regulator Gene Mutations in Patients with Allergic Bronchopulmonary Aspergillosis Complicating Asthma

Cited by 8 publications

References 43 publications

Aspergillus Sensitization and Allergic Bronchopulmonary Aspergillosis in Asthmatic Children: A Systematic Review and Meta-Analysis

Aspergillus Sensitization and Allergic Bronchopulmonary Aspergillosis in Asthmatic Children: A Systematic Review and Meta-Analysis

Allergic bronchopulmonary aspergillosis in India

Epidemiology of the relationship between allergic bronchopulmonary aspergillosis and asthma

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