2017
DOI: 10.1016/j.foodchem.2017.03.085
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Occurrence of deoxynivalenol and deoxynivalenol-3-glucoside in durum wheat from Argentina

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Cited by 85 publications
(39 citation statements)
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“…Aflatoxin metabolism differs between children and adults (Dohnal et al 2014) and the aflatoxin pharmacokinetics is still not completely explored (Dohnal et al 2014). Liver is the dominant site of aflatoxin metabolism, where aflatoxins are converted to 8,9-epoxide form during the phase I metabolism by primary cytochrome P450 (CYP) enzymes, such as CYP3A4, CYP3A5, CYP3A7 and CYP1A2 (Palacios et al 2017;Wild and Turner 2002). CYP3A4, CYP1A2 and CYP3A7 in the liver oxidize AFB1 to form AFB1-8,9exoepoxide and AFB1-endo-epoxide.…”
Section: Aflatoxin B1mentioning
confidence: 99%
See 1 more Smart Citation
“…Aflatoxin metabolism differs between children and adults (Dohnal et al 2014) and the aflatoxin pharmacokinetics is still not completely explored (Dohnal et al 2014). Liver is the dominant site of aflatoxin metabolism, where aflatoxins are converted to 8,9-epoxide form during the phase I metabolism by primary cytochrome P450 (CYP) enzymes, such as CYP3A4, CYP3A5, CYP3A7 and CYP1A2 (Palacios et al 2017;Wild and Turner 2002). CYP3A4, CYP1A2 and CYP3A7 in the liver oxidize AFB1 to form AFB1-8,9exoepoxide and AFB1-endo-epoxide.…”
Section: Aflatoxin B1mentioning
confidence: 99%
“…AFB1-endo-epoxide is less toxic as it cannot bind to nucleic acids (Dohnal et al 2014;Palacios et al 2017;Wild and Turner 2002). However, exo-and endo-epoxide through non-enzymatic hydrolysis can form AFB1-8,9-dihydrodiol which reacts with the ε-amino group of lysine in serum albumin and can be detected in blood (Dohnal et al 2014;Wild and Turner 2002).…”
Section: Aflatoxin B1mentioning
confidence: 99%
“…Deoxynivalenol (DON) is the most serious of these toxins. DON can lead to poisoning in people or animals and persists in the food chain for a long time [4,5]. If the disease in the field can be detected earlier and quicker, wheat containing the toxins can be isolated, which can reduce the loss caused by disease.…”
Section: Introductionmentioning
confidence: 99%
“…It was reported that the mean concentrations of D3G were 393 µg/kg and 141 µg/kg, respectively, for wheat and maize samples [14]. Palacios et al (2017) [15] reported that D3G was detected in 94% of the investigated durum wheat commercial cultivars from the Argentinean main growing area at concentrations ranging from < the limit of quantification (LOQ, 50 µg/kg) to 850 µg/kg. Lancova et al (2008) [16] found D3G in naturally contaminated barley, and a remarkable increase of D3G was observed in malt compared to raw barley.…”
Section: Introductionmentioning
confidence: 99%