Occurrence of endometrial cancer six years after treatment with thermal balloon ablation (Thermachoice®): first case report

Marrec, Aurelie Le; Lavoué, Vincent; Morcel, Karine; Duval, Hélène; Bauville, Estelle; Foucher, Fabrice; Lévèque, Jean

doi:10.1016/j.ejogrb.2010.02.045

Cited by 3 publications

(2 citation statements)

References 5 publications

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“…Eventually, 11 articles were included in the systematic review on incidence of endometrial cancer after endometrial ablation; nine retrospective studies, one prospective cohort study, and one randomized controlled trial 3 13–16 22–27. Twenty-four articles were included describing a total of 38 individual cases of endometrial cancer after ablation 3 11 13–15 22–25 27–41. The flow diagram for study selection is shown in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

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Endometrial cancer after endometrial ablation: a systematic review

Oderkerk

Kar

Cornel

et al. 2022

Int J Gynecol Cancer

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ObjectiveTo investigate whether a previously performed endometrial ablation is associated with the development and diagnosis of endometrial cancer.MethodsFirst, a systematic review was performed of the articles reporting the incidence of endometrial cancer in patients treated with endometrial ablation. Second, a systematic review was performed to identify all individual cases of endometrial cancer after ablation to evaluate presenting symptoms, diagnostic work-up, potential risk factors, and the type and stage of the endometrial cancer. A systematic search was performed, using Medline, EMBASE, and the Cochrane Library databases, from inception through February 24, 2022.ResultsBased on 11 included studies, the incidence of endometrial cancer in a population of 29 102 patients with a prior endometrial ablation ranged from 0.0% to 1.6%.A total of 38 cases of endometrial cancer after ablation were identified. In 71% of cases (17 of 24 cases), vaginal bleeding was the first presenting symptom. With transvaginal ultrasound it was possible to identify and measure the endometrial thickness in eight cases. Endometrium sampling was successful in 16 of 18 described cases (89%). In 18 of 20 cases (90%) pathologic examination showed early-stage endometrioid adenocarcinoma (International Federation of Gynecology and Obstetrics stage I).ConclusionPrevious endometrial ablation is not associated with the development of endometrial cancer. Diagnostic work-up is not impeded by previous endometrial ablation. In addition, endometrial cancers after endometrial ablation are not detected at an advanced stage.

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Section: Resultsmentioning

confidence: 99%

“…From our extensive search, 24 articles were included describing single or multiple cases of endometrial cancer after ablation 3 11 13–15 22–25 27–41. In total 38 cases were described.…”

Section: Resultsmentioning

confidence: 99%

Endometrial cancer after endometrial ablation: a systematic review

Oderkerk

Kar

Cornel

et al. 2022

Int J Gynecol Cancer

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Endometrial Cancer After Endometrial Ablation vs Medical Management of Abnormal Uterine Bleeding

Dood

Gracia

Sammel

et al. 2014

Journal of Minimally Invasive Gynecology

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Study Objective To investigate whether endometrial ablation carries an increased risk or delayed diagnosis of endometrial cancer compared to medical management for abnormal uterine bleeding. Design A multi-centered retrospective cohort study comparing rates of endometrial cancer in women who underwent treatment for abnormal uterine bleeding. Design Classification Canadian Task-Force Classification II-2 Setting This study was conducted using data from The Health Improvement Network (THIN), a representative population-based cohort of patients in 495 outpatient General Practitioner practices in the UK. Participants Women >25 years of age with an abnormal uterine bleeding diagnosis between June 1994 and September 2010. Interventions Endometrial ablation, medical management, or both. Measurements and Main Results A total of 234,721 women met study inclusion and exclusion criteria, 4,776 of whom underwent endometrial ablation and the remaining 229,945 underwent medical management. Cox models compared endometrial cancer rates between ablation and medical management groups using hazard ratios (HRs). To investigate a possible diagnostic delay, the median time from bleeding diagnosis to endometrial cancer diagnosis among women who developed endometrial cancer was compared using the Mann-Whitney U test. All statistical tests were two-tailed with α=.05. Over a median observation time of 4.07 years (IQR, 1.88-7.17), three and 601 women developed endometrial cancer in the ablation and medical management groups, respectively (ablation HR, 0.45; 95% CI, 0.15-1.40; p=.17). Median time to diagnosis was 237 and 299 days (ablation IQR, 155-1350; medical management IQR, 144-1,133.5; p=.99) in the ablation and medical management groups, respectively. Adjusted and sensitivity analyses did not change the results. Conclusions No difference was seen in endometrial cancer rates, nor was there a delay in diagnosis when comparing endometrial ablation versus medical management. Further studies are needed to investigate the impact of prior ablation exposure on histology or cancer stage at presentation of endometrial cancer.

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Response to Letter to the Editor: Author's Reply

Laberge¹

2017

Journal of Minimally Invasive Gynecology

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Occurrence of endometrial cancer six years after treatment with thermal balloon ablation (Thermachoice®): first case report

Cited by 3 publications

References 5 publications

Endometrial cancer after endometrial ablation: a systematic review

Endometrial cancer after endometrial ablation: a systematic review

Endometrial Cancer After Endometrial Ablation vs Medical Management of Abnormal Uterine Bleeding

Response to Letter to the Editor: Author's Reply

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