Occurrence of fatigue over 20 years after recovery from Guillain–Barré syndrome

Drory, Vivian E.; Bronipolsky, Tanja; Bluvshtein, Vadim; Catz, Amiram; Korczyn, Amos D.

doi:10.1016/j.jns.2012.01.024

Cited by 24 publications

(33 citation statements)

References 21 publications

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“…Over the past decades, loss of energy or fatigue has received attention as a disabling symptom after Guillain-Barré syndrome. 22 Fatigue does not seem to be related to level of disability. In a British questionnaire study, about 40% of patients reported experiencing severe fatigue, despite being healthy or having only minor symptoms.…”

Section: Discussionmentioning

confidence: 92%

Balancing everyday life two years after falling ill with Guillain-Barré syndrome: a qualitative study

2014

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Section: Discussionmentioning

confidence: 92%

Balancing everyday life two years after falling ill with Guillain-Barré syndrome: a qualitative study

2014

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“…The prevalence of fatigue in patients with neuromuscular disorders ranges from 38 to 86%. [10] However, one recent study shows prevalence of severe fatigue using FSS in 30% of the patients of GBS, after more than 1 year of onset of disease. [22]…”

Section: Discussionmentioning

confidence: 99%

“…Most of the studies[691011] have focused on the prevalence of fatigue, following maximal recovery. After extensive literature search, we could not find any study that has seen prevalence of fatigue in GBS in subacute setting.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of fatigue in Guillain-Barre syndrome in neurological rehabilitation setting

Ranjani

Khanna

Gupta

et al. 2014

Ann Indian Acad Neurol

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Background:Fatigue contributes significantly to the morbidity and affects the quality of life adversely in Guillain-Barre Syndrome (GBS).Objective:To determine the prevalence of fatigue in GBS in neurological rehabilitation setting and to study its clinical correlates.Materials and Methods:We performed secondary analysis of data of patients with GBS admitted in neurological rehabilitation ward of a tertiary care centre, recorded at both admission and discharge. Assessment of fatigue was done by Fatigue Severity Scale (FSS), disability-status by Hughe's Disability Scale (HDS), functional-status by Barthel Index, anxiety/depression by Hospital Anxiety Depression Scale, sleep disturbances by Pittsburgh Sleep Quality Index and muscle weakness by Medical Research Council sum scores.Results:A total of 90 patients (62 men) with mean age 34 years (95% CI 32.2, 37.7) were included. Median duration of, stay at neurological rehabilitation ward was 30 days, while that of symptoms was 18.5 days. Presence of fatigue at admission (FSS ≥ 4 in 39% patients) was associated with ventilator requirement (P = 0.021) and neuropathic pain (P = 0.03). Presence of fatigue at discharge (FSS ≥ 4 in 12% patients) was associated with disability- HDS (≥3) (P = 0.008), presence of anxiety (P = 0.042) and duration of stay at rehabilitation ward (P = 0.02). Fatigue did not correlate with age, gender, antecedent illness, muscle weakness, depression and sleep disturbances.Conclusion:Fatigue is prevalent in GBS during early recovery phase of illness. Despite motor recovery fatigue may persist. Knowledge about fatigue as burden of disease in these patients will improve patient care.

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“…The geographic distribution of pain is broad, and pain can occur as a sentinel symptom prior to weakness, along with the onset of weakness, and can continue for at least 2 years [6]. Fatigue may persist for decades after the weakness from GBS has resolved, indicating multimodal long-term impact in some patients [7]. GBS is now recognized as a neurologic illness where pain occupies a major clinical dimension.…”

Section: Introductionmentioning

confidence: 99%

Headache and Pain in Guillain-Barré Syndrome

Farmakidis

Inan

Milstein

et al. 2015

Curr Pain Headache Rep

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While moderate and severe back or extremity pain is frequent in Guillain-Barré syndrome (GBS), headache appears to be uncommon. Most of the reports of headache in GBS place it in the context of the posterior reversible encephalopathy syndrome (PRES) which is increasingly recognized as a likely dysautonomia-related GBS complication. There are also a few reports of headache in the setting of increased CSF pressure and papilledema and in association with the Miller Fisher GBS variant. In comparison, back and extremity pain is highly prevalent. Aching muscle pain and neuropathic pain are the two most common of several pain types. Pain may be a heralding feature and has been described in patients as long as 2 years after disease onset. Pain management is a major axis of treatment in GBS. Gabapentin is a reasonable first-line choice, and opioid medications can be added for more severe pain but there are few clinical trials to inform specific recommendations. While the understanding of pain pathophysiology in GBS is incomplete, its prevalence and clinical impact are increasingly recognized and studied. Pain should be considered a cardinal manifestation of GBS along with acute, mostly symmetric weakness and diminished reflexes.

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Occurrence of fatigue over 20 years after recovery from Guillain–Barré syndrome

Cited by 24 publications

References 21 publications

Balancing everyday life two years after falling ill with Guillain-Barré syndrome: a qualitative study

Balancing everyday life two years after falling ill with Guillain-Barré syndrome: a qualitative study

Prevalence of fatigue in Guillain-Barre syndrome in neurological rehabilitation setting

Headache and Pain in Guillain-Barré Syndrome

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