Occurrence of free D-aspartic acid in the circumsoesophageal ganglia of

D’Aniello, Antimo; Nardi, G.; Vetere, Amedeo; Ferguson, G. P.

doi:10.1016/0024-3205(93)90235-u

Cited by 37 publications

(16 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Free D-Asp is found in the nervous system of Aplysia (D’Aniello et al, 1993; Liu et al, 1998; Miao et al, 2005; Miao et al, 2006; Spinelli et al, 2006) and vertebrates (D’Aniello, 2007). D-Asp activates an excitatory, non-specific cation channel in BSC neurons (Carlson & Fieber, unpublished).…”

Section: Discussionmentioning

confidence: 99%

Unique ionotropic receptors for D-aspartate are a target for serotonin-induced synaptic plasticity in Aplysia californica

Carlson

Fieber

2012

Comparative Biochemistry and Physiology Part C: Toxicology &

View full text Add to dashboard Cite

The non-L-glutamate (L-Glu) receptor component of D-aspartate (D-Asp) currents in Aplysia californica buccal S cluster (BSC) neurons was studied with whole cell voltage clamp to differentiate it from receptors activated by other well-known agonists of the Aplysia nervous system and investigate modulatory mechanisms of D-Asp currents associated with synaptic plasticity. Acetylcholine (ACh) and serotonin (5-HT) activated whole cell excitatory currents with similar current voltage relationships to D-Asp. These currents, however, were pharmacologically distinct from D-Asp. ACh currents were blocked by hexamethonium (C6) and tubocurarine (d-TC), while D-Asp currents were unaffected. 5-HT currents were blocked by granisetron and methysergide (MES), while D-Asp currents were unaffected. Conversely, while (2S,3R)-1-(Phenanthren-2-carbonyl)piperazine-2,3-dicarboxylic acid(PPDA) blocked D-Asp currents, it had no effect on ACh or 5-HT currents. Comparison of the charge area described by currents induced by ACh or 5-HT separately from, or with, D-Asp suggests activation of distinct receptors by all 3 agonists. Charge area comparisons with L-Glu, however, suggested some overlap between L-Gluand D-Asp receptors. Ten minute exposure to 5-HT induced facilitation of D-Asp-evoked responses in BSC neurons. This effect was mimicked by phorbol ester, suggesting that protein kinase C (PKC) was involved.

show abstract

Section: Discussionmentioning

confidence: 99%

Unique ionotropic receptors for D-aspartate are a target for serotonin-induced synaptic plasticity in Aplysia californica

Carlson

Fieber

2012

Comparative Biochemistry and Physiology Part C: Toxicology &

View full text Add to dashboard Cite

show abstract

“…It was reported first in the brain and optic lobes of Octopus vulgaris , with D-Asp measurements performed using liquid chromatography and the clever approach of selective degradation via the enzyme D-Asp oxidase (DAspO) (D’Aniello and Giuditta 1977). Since then, D-Asp has been reported in the nervous system of other invertebrate animals spanning a number of phyla: mollusks such as the cephalopods Sepia officinalis and Loligo vulgaris (D’Aniello and Giuditta 1978; D’Aniello et al 1995b); opisthobranchs such as Aplysia fasciata (D’Aniello et al 1993b), Aplysia californica (Liu et al 1998), and Aplysia limacine (Spinelli et al 2006); arthropods such as the crustacean Jasus lalandii (Okuma and Abe 1994); and protochordates, including the tunicate Ciona intestinalis (D’Aniello et al 2003) and amphioxus Branchiostoma lanceolatum (D’Aniello and Garcia-Fernandez 2007). D-Asp has also been found in reproductive tissues such as the glands of O. vulgaris (D’Aniello et al 1995a).…”

Section: D-asp Distributionmentioning

confidence: 99%

“…D-aspartic acid (D-Asp) is a D-amino acid that has received significant attention because of its presence in animal nervous and reproductive systems (D’Aniello and Giuditta 1977; Dunlop et al 1986; Fisher et al 1991; Hashimoto et al 1993; D’Aniello et al 1996; Schell et al 1997; D’Aniello 2007; Homma 2007); however, questions about its metabolism, cellular function, biological and physiological roles, and pathological significance remain. Investigations of D-Asp in living organisms have involved various animals, including cephalopods (D’Aniello and Giuditta 1977; D’Aniello et al 1995b; D’Aniello et al 2011), gastropods (D’Aniello et al 1993b; Shibata et al 2003; Miao et al 2006a; Spinelli et al 2006), amphibians (Di Fiore et al 1998; Raucci and Di Fiore 2011), reptiles (Assisi et al 2001; Raucci and Di Fiore 2010), and mammals, including humans (Fisher et al 1991; Hamase et al 1999; Morikawa et al 2007). These studies document its widespread occurrence and suggest that D-Asp plays important roles throughout the Metazoan.…”

Section: Introductionmentioning

confidence: 99%

d-Aspartate acts as a signaling molecule in nervous and neuroendocrine systems

2012

View full text Add to dashboard Cite

D-Aspartate (D-Asp) is an endogenous amino acid in the central nervous and reproductive systems of vertebrates and invertebrates. High concentrations of D-Asp are found in distinct anatomical locations, suggesting that it has specific physiological roles in animals. Many of the characteristics of D-Asp have been documented, including its tissue and cellular distribution, formation and degradation, as well as the responses elicited by D-Asp application. D-Asp performs important roles related to nervous system development and hormone regulation; in addition, it appears to act as a cell-to-cell signaling molecule. Recent studies have shown that D-Asp fulfills many, if not all, of the definitions of a classical neurotransmitter—that the molecule’s biosynthesis, degradation, uptake, and release take place within the presynaptic neuron, and that it triggers a response in the postsynaptic neuron after its release. Accumulating evidence suggests that these criteria are met by a heterogeneous distribution of enzymes for D-Asp’s biosynthesis and degradation, an appropriate uptake mechanism, localization within synaptic vesicles, and a postsynaptic response via an ionotropic receptor. Although D-Asp receptors remain to be characterized, the postsynaptic response of D-Asp has been studied and several L-glutamate receptors are known to respond to D-Asp. In this review we discuss the current status of research on D-Asp in neuronal and neuroendocrine systems, and highlight results that support D-Asp’s role as a signaling molecule.

show abstract

“…Numerous studies have confirmed the widespread presence of D-Asp in each of the ganglia of the Aplysia CNS in multiple species such as A. fasciata (D'Aniello et al 1993), A. limacina (Spinelli et al 2006), and A. californica (Liu et al 1998;Miao et al 2005Miao et al , 2006. L-Glu receptors are found throughout the Aplysia nervous system, including the well-studied NMDA- (Ha et al 2006) and AMPA-type receptors that activate channels (Antzoulatos and Byrne 2004), as well as the invertebrate-specific L-Glu-activated Cl Ϫ channels (King and Carpenter 1989).…”

mentioning

confidence: 91%