Occurrence of H2-receptors for histamine in the guinea-pig intestine

Bareicha, Ivone; Silva, M.Rocha e

doi:10.1016/0006-2952(75)90065-9

Cited by 22 publications

(3 citation statements)

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“…These studies showed that only HI-histamine receptor antagonists (mepyramine, chlorcyclizine and diphenhydramine) could reduce the contraction to plocamadiene A. Hz-histamine receptor antagonists potentiated the response to both plocamadiene A and histamine. Bareicha and Rocha e Silva (1975) have previously reported that Hz-histamine receptor antagonists potentiate responses to histamine in the longitudinal muscle of the GPI. This, coupled with the observation that the plocamadiene A response decreased following frequent application, suggested that plocamadiene A may cause release of histamine from cells in the GPI.…”

Section: Discussionmentioning

confidence: 95%

THE NOVEL MARINE NATURAL PRODUCT PLOCAMADIENE A CAUSES HISTAMINE RELEASE FROM MAST CELLS OF THE GUINEA‐PIG AND RAT IN VITRO

Thomas

Beveridge

1993

Clin Exp Pharma Physio

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1. Plocamadiene A is a polyhalogenated monoterpene, (1R, 2S, 4S, 1'E)-2-bromo-1-chloro-4-(2'-chloroethenyl)-1-methyl-5- methylenecyclohexane, isolated from red marine algae of the Plocamium genus. 2. This study examined the activity of plocamadiene A on guinea-pig isolated ileum (GPI) and subsequently on rat isolated peritoneal mast cells. 3. Plocamadiene A (1 micrograms/mL) produced a slow onset, sustained contraction of the GPI. This was insensitive to atropine (1 mumol/L) and tetrodotoxin (1 mumol/L), but was significantly reduced by H1-histamine receptor antagonists including mepyramine (10 nmol/L), chlorcyclizine (10 nmol/L) and diphenhydramine (0.1 mumol/L). The H2-histamine receptor antagonists cimetidine (0.1 mumol/L) and ranitidine (10 nmol/L) potentiated the response to plocamadiene A (1 micrograms/mL). 4. The amplitude of contraction caused by plocamadiene A (1 micrograms/mL) gradually decreased when the compound was applied repeatedly to the GPI for 5 min every 10 min for 150 min. 5. Contractions to plocamadiene A (1 micrograms/mL) were reduced to approximately 66% of the time control in ovalbumin-sensitized GPI challenged with ovalbumin to release endogenous contractile agents. 6. Cromolyn (0.1 mmol/L) inhibited (by 40%) the response in the GPI caused by plocamadiene A (1 micrograms/mL) as compared with time controls. 7. Spectrofluorometric assay suggested that both plocamadiene A (10 micrograms/mL) and compound 48/80 (10 micrograms/mL) caused histamine release from rat peritoneal mast cells in vitro. This release of histamine was reduced by cromolyn (100 micrograms/mL). 8. This study concluded that plocamadiene A releases histamine from mast cells of the GPI and peritoneal mast cells in the rat.

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Section: Discussionmentioning

confidence: 95%

THE NOVEL MARINE NATURAL PRODUCT PLOCAMADIENE A CAUSES HISTAMINE RELEASE FROM MAST CELLS OF THE GUINEA‐PIG AND RAT IN VITRO

Thomas

Beveridge

1993

Clin Exp Pharma Physio

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“…We calculated the proportion of H 2-receptors in relation to the total number of H 1-receptors for histamine in the coronary artery following a method described by BAREICHA and ROCHA E SmVA [5], which is based on Clark's equation for the description of the interaction of an agonist with its own receptors. The method's prerequisite is the proportionality between receptor occupation and action.…”

Section: Resultsmentioning

confidence: 99%

Histamine H1- and H2-receptors in coronary arteries of pigs

Hagen

Paegelow

1979

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Histamine exerts its action in smooth muscle via in two types of receptors. In coronary arteries of pigs both types of receptors are also involved in responses to histamine. Histamine initiates by an interaction with H1-receptors a contraction and with H2-receptors a relaxation. The histamine-induced contraction is reduced by the competitively antagonistic action of mepyramine. Metiamide potentiates dose-dependently the histamine-caused contraction in the absence and presence of mepyramine. The proportion of H2-receptors in relation to H1-receptors is calculated.

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“…Οι απόψεις όμως των ερευνητών διίστανται για το αν η ισταμίνη προκαλεί και κάποιου βαθμού χαλάρωση στο έντερο του ενήλικου ινδοχοίρου και αν οι ^-ανταγωνιστές αναστέλλουν την ενέργεια αυτή. Η άποψη ότι η ισταμίνη εκτός από σύσπαση προκαλεί και χαλάρωση στο έντερο του ενήλικου ινδοχοίρου διατυπώθηκε για πρώτη φορά από τους Ambache και Aboo Zar (1970) και ενισχύθηκε αργότερα από τους ίδιους και από άλλους ερευνητές (Ambache και συν., 1973* Bareicha και Rocha e Silva, 1975,1976-Fjalland, 1979. Ωστόσο, αντίθετη άποψη διατύπωσαν άλλοι ερευνητές (Zavecz και Yellin, 1982" Bielkiewicz και Cook, 1983, οι οποίοι υποστήριξαν ότι η ισταμίνη προκαλεί αποκλειστικά σύσπαση στο έντερο .…”

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Μεταβολες Στη Δραση Της Ισταμινης Και Αγωνιστων Της Απο Η1- Και Η2- Ανταγωνιστες: Μυογραφικη Μελετη Στο Απομονωμενο Εντερο Του Ινδοχοιρου Κατα Τη Διαρκεια Τησαναπτυξης

Κουτσοβίτη-Παπαδοπούλου¹,

Koutsoviti-Papadopoulou²

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Occurrence of H2-receptors for histamine in the guinea-pig intestine

Cited by 22 publications

References 4 publications

THE NOVEL MARINE NATURAL PRODUCT PLOCAMADIENE A CAUSES HISTAMINE RELEASE FROM MAST CELLS OF THE GUINEA‐PIG AND RAT IN VITRO

THE NOVEL MARINE NATURAL PRODUCT PLOCAMADIENE A CAUSES HISTAMINE RELEASE FROM MAST CELLS OF THE GUINEA‐PIG AND RAT IN VITRO

Histamine H1- and H2-receptors in coronary arteries of pigs

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