Occurrence of histoplasmosis in Asia

Randhawa, H. S.

doi:10.1007/bf02051485

Cited by 33 publications

(34 citation statements)

References 49 publications

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“…Cases have also been reported in the following Asian countries: India, Indonesia, Malaysia, Thailand, Singapore, Viet Nam and Japan. Skin-test surveys indicate positivity rates of 5 to 15 % in Turkey, Iran, India, Bangladesh, Thailand and Malaysia; and rates of 34 to 86 % in parts of Burma, Viet Nam, Indonesia and Japan (3,4).…”

Section: Historymentioning

confidence: 97%

Diagnosis and management of Histoplasmosis

1989

Eur. J. Clin. Microbiol. Infect. Dis.

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Histoplasmosis occurs throughout the world but is more common within the endemic areas of North America, particularly in fertile river valleys. Disease manifestations range from asymptomatic infection in the normal host with low-inoculum exposure to rapidly fatal, disseminated infection in the severely immunocompromised host, emphasizing the importance of cellular immunity in defense against Histoplasma capsulatum. Diagnosis depends on a high index of suspicion, knowledge of the clinical and epidemiologic features of the infection, and a thorough understanding of the uses and limitations of fungal cultural and serological laboratory procedures. Recently, a method has been developed for rapid diagnosis based on detection of a polysaccharide antigen in body fluids of patients with histoplasmosis. Amphotericin B remains the preferred treatment for more severe forms of histoplasmosis, particularly in the immunocompromised host, but oral treatment with ketoconazole or newer imidozoles appears to be effective in less severe infections in non-immunocompromised individuals.

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Section: Historymentioning

confidence: 97%

Diagnosis and management of Histoplasmosis

1989

Eur. J. Clin. Microbiol. Infect. Dis.

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“…Table 2 shows studies from outside of the USA 37–59 , while Figure 1 shows a world map constructed with estimated areas endemic to histoplasmosis based on case reports primarily among HIV-infected patients.…”

Section: Global Distribution Of Histoplasmosismentioning

confidence: 99%

Histoplasmosis Infections Worldwide: Thinking Outside of the Ohio River Valley

et al. 2015

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In the United States, histoplasmosis is generally thought to occur mainly in the Ohio and Mississippi River Valleys, and the classic map of histoplasmosis distribution reflecting this is second nature to many U.S. physicians. With the advent of the HIV pandemic reports of patients with progressive disseminated histoplasmosis and AIDS came from regions of known endemicity, as well as from regions not thought to be endemic for histoplasmosis throughout the world. In addition, our expanding armamentarium of immunosuppressive medications and biologics has increased the diagnosis of histoplasmosis worldwide. While our knowledge of areas in which histoplasmosis is endemic has improved, it is still incomplete. Our contention is that physicians should consider histoplasmosis with the right constellations of symptoms in any febrile patient with immune suppression, regardless of geographic location or travel history.

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“…1 In Asia, the lion's share of cases has been reported from Thailand 2 and China 3 with only sporadic cases from Taiwan, India, Malaysia, and Singapore. 4,5 However, elevated rates of histoplasmin skin hypersensitivity on cohort screening, up to 86% in some areas, 1 suggest that a large portion of the population is exposed to the fungus, raising the possibility that disease may be under-recognized. In the Philippines, despite a histoplasmin skin hypersensitivity rate of 26% in one study, 6 only one microbiologically confirmed case of histoplasmosis presenting with diffuse papulonodular skin lesions has been described, 7 whereas four other cases were presumptively diagnosed by histopathology alone.…”

Section: Introductionmentioning

confidence: 99%

Disseminated Histoplasmosis with Skin Lesions and Osteomyelitis in a Patient from the Philippines

Azar

Malinis

2016

The American Society of Tropical Medicine and Hygiene

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Histoplasmosis, caused by the dimorphic fungus Histoplasma capsulatum, is a disease of protean manifestations and of global distribution. Although increasingly reported in Asia, there are few reports from the Philippines. Here, we describe a case of microbiologically diagnosed histoplasmosis, probably acquired from the Philippines, in a returning traveler who presented with a right foot wound and papular rash. The final diagnosis was disseminated histoplasmosis with cutaneous and bone involvement, both unusual manifestations of the disease.

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Occurrence of histoplasmosis in Asia

Cited by 33 publications

References 49 publications

Diagnosis and management of Histoplasmosis

Diagnosis and management of Histoplasmosis

Histoplasmosis Infections Worldwide: Thinking Outside of the Ohio River Valley

Disseminated Histoplasmosis with Skin Lesions and Osteomyelitis in a Patient from the Philippines

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