Occurrence of metachronous second primary cancer in head and neck cancer survivors: A systematic review and meta‐analysis of the literature

Hoxhaj, Ilda; Hysaj, Ola; Vuković, Vladimir; Leoncini, Emanuele; Amore, Rosarita; Pastorino, Roberta; Boccia, Stefania

doi:10.1111/ecc.13255

Cited by 14 publications

(14 citation statements)

References 78 publications

(157 reference statements)

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“…Similar results were reported in a population-based cohort study of 64,673 HN cancer patients in the National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) registry between 1979 and 2008, in which the standardized incidence ratio (SIR) of synchronous SPTs was 5.0, with the highest excess risk of a second cancer at the HN region (SIR, 41.4), followed by the esophagus (SIR, 21.8), and lungs (SIR, 7.4) ( 53 ). In addition, a meta-analysis reported an SIR for metachronous SPTs, which were defined as occurring six months after the primary index tumor, of 2.04 (95% CI, 1.61~2.59) ( 9 ). The highest risk for metachronous SPTs located at the HN region was for the oropharynx (SIR, 17.82; 95% CI, 6.79–46.77), followed by the hypopharynx (SIR, 9.17; 95% CI, 3.51–23.98) and larynx (SIR, 4.12; 95% CI, 2.87–5.90), while the highest risk for SPTs located outside the HN area was for the esophagus (SIR, 4.64; 95% CI, 3.12–6.89), followed by the salivary glands (SIR, 8.30; 95% CI, 2.37–29.09) and thyroid (SIR, 1.47; 95% CI, 1.22–1.76) ( 9 ).…”

Section: Association Between Hn and Esophageal Cancersmentioning

confidence: 99%

“…In addition, a meta-analysis reported an SIR for metachronous SPTs, which were defined as occurring six months after the primary index tumor, of 2.04 (95% CI, 1.61~2.59) ( 9 ). The highest risk for metachronous SPTs located at the HN region was for the oropharynx (SIR, 17.82; 95% CI, 6.79–46.77), followed by the hypopharynx (SIR, 9.17; 95% CI, 3.51–23.98) and larynx (SIR, 4.12; 95% CI, 2.87–5.90), while the highest risk for SPTs located outside the HN area was for the esophagus (SIR, 4.64; 95% CI, 3.12–6.89), followed by the salivary glands (SIR, 8.30; 95% CI, 2.37–29.09) and thyroid (SIR, 1.47; 95% CI, 1.22–1.76) ( 9 ). In a study that defined a metachronous SPT as occurring 2 months after the primary HN cancer, an increased risk for metachronous SPTs of the lungs (SIR, 4.32; 95% CI 2.15-8.68) was also noted ( 9 ).…”

Section: Association Between Hn and Esophageal Cancersmentioning

confidence: 99%

“…The highest risk for metachronous SPTs located at the HN region was for the oropharynx (SIR, 17.82; 95% CI, 6.79–46.77), followed by the hypopharynx (SIR, 9.17; 95% CI, 3.51–23.98) and larynx (SIR, 4.12; 95% CI, 2.87–5.90), while the highest risk for SPTs located outside the HN area was for the esophagus (SIR, 4.64; 95% CI, 3.12–6.89), followed by the salivary glands (SIR, 8.30; 95% CI, 2.37–29.09) and thyroid (SIR, 1.47; 95% CI, 1.22–1.76) ( 9 ). In a study that defined a metachronous SPT as occurring 2 months after the primary HN cancer, an increased risk for metachronous SPTs of the lungs (SIR, 4.32; 95% CI 2.15-8.68) was also noted ( 9 ). Another systematic review of 456,130 HN cancer patients from 61 articles with a minimum follow-up of 22 months reported a mean incidence of SPTs of 13.2% (95% CI, 11.56-14.84), including 5.3% for synchronous SPTs (95% CI, 4.24-6.36) and 9.4% for metachronous SPTs (95% CI, 7.9-10.9) ( 54 ).…”

Section: Association Between Hn and Esophageal Cancersmentioning

confidence: 99%

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Endoscopic Screening for Second Primary Tumors of the Esophagus Among Head and Neck Cancer Patients

Chung

Liao

et al. 2022

Front. Oncol.

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Malignancies of the head and neck (HN) region and esophagus are among the most common cancers worldwide. Due to exposure to common carcinogens and the theory of field cancerization, HN cancer patients have a high risk of developing second primary tumors (SPTs). In our review of 28 studies with 51,454 HN cancer patients, the prevalence of SPTs was 12%. The HN area is the most common site of SPTs, followed by the lungs and esophagus, and 13% of HN cancer patients have been reported to have esophageal high-grade dysplasia or invasive carcinoma. The prognosis of HN cancer patients with concomitant esophageal SPTs is poor, and therefore identifying esophageal SPTs as early as possible is of paramount importance for risk stratification and to guide the treatment strategy. Image-enhanced endoscopy, especially using narrow-band imaging endoscopy and Lugol’s chromoendoscopy, has been shown to improve the diagnostic performance in detecting esophageal neoplasms at an early stage. Moreover, the early detection and minimally invasive endoscopic treatment of early esophageal neoplasm has been shown to improve the prognosis. Well-designed prospective studies are warranted to establish appropriate treatment and surveillance programs for HN cancer patients with esophageal SPTs.

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Section: Association Between Hn and Esophageal Cancersmentioning

confidence: 99%

Section: Association Between Hn and Esophageal Cancersmentioning

confidence: 99%

Section: Association Between Hn and Esophageal Cancersmentioning

confidence: 99%

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Endoscopic Screening for Second Primary Tumors of the Esophagus Among Head and Neck Cancer Patients

Chung

Liao

et al. 2022

Front. Oncol.

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“…Head and neck cancer (HNC) is a group of cancers that occur in oral cavity, pharynx and larynx, it is the sixth most common cancer, with approximately 650.000 new cases and 300.000 deaths annually [1]. Although the overall survival-rate after the primary HNC have increased [2] due to an improved diagnosis and therapeutic approaches, the incidence of second primary cancer (SPC) remains one of the main long-term causes of mortality [3,4]. It is estimated that approximately 15-25% of HNC patients develop SPCs within five years of initial diagnosis [5,6].…”

Section: Introductionmentioning

confidence: 99%

Single nucleotide polymorphisms and the risk of developing a second primary cancer among head and neck cancer patients: a systematic literature review and meta-analysis

et al. 2021

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Background Head and Neck Cancer (HNC) survivors are at increased risk of developing a second primary cancer (SPC). Along with the environmental risk factors, genetic factors have been associated with a potential increased susceptibility to SPC development. We aim to identify the Single Nucleotide Polymorphisms (SNPs) that contribute to SPC development among HNC survivors through a systematic review and meta-analysis. Methods We searched PubMed, Scopus and ISI Web of Science for eligible studies published in English until January 31st, 2020. We included studies reporting primary data that evaluated the association between SNPs and SPC risk in HNC patients. Data were pooled in a random-effect meta-analyses, when at least two studies on the same SNP evaluated the same genotype model. Heterogeneity was assessed using the χ2-based Q-statistics and the I2 statistics. Quality of the included studies was assessed using the Q-Genie tool. Results Twenty-one studies, of moderate to good quality, were included in the systematic review. Fifty-one genes were reported across the included studies to have significant associations with an increased SPC risk. Overall, 81 out of 122 investigated SNPs were significantly associated with the SPC risk. Seven studies were included in the meta-analysis, which showed five SNPs associated with an increased risk of SPC: p21C70T, CT + TT (HR = 1.76; 95% CI: 1.28–2.43); FASLG -844C > T, CT + TT (HR = 1.82; 95% CI: 1.35–2.46), P21 C98A, CA + AA (HR = 1.75; 95% CI: 1.28–2.38); FAS -670A > G (HR = 1.84; 95% CI: 1.28–2.66) and GST-M1, Null genotype (HR = 1.54; 95% CI: 1.13–2.10). Conclusions The identified SNPs in our systematic review and meta-analysis might serve as potential markers for identification of patients at high risk of developing SPC after primary HNC. PROSPERO Registration Number CRD42019135612.

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“…In addition to anogenital cancers, head and neck cancer is the sixth leading cancer worldwide with 600,000 new cases per year and a mortality rate of around 450,000 per year, occupying 78% of HPV-related oropharynx cancer cases [1,5]. Meanwhile, the HPV positive oropharyngeal cancers have been increasing during the last decade, even though the consumption of tobacco declining, especially among youngsters in more developed countries [1].…”

Section: Introductionmentioning

confidence: 99%

PD-L1 expression in anogenital and oropharyngeal squamous cell carcinomas associated with different clinicopathological features, HPV status and prognosis: a meta-analysis

Yuan

Luan

et al. 2020

Preprint

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BackgroundLittle research has been done on clinicopathological characteristics and human papillomavirus (HPV) status of anogenital and oropharyngeal squamous cell carcinomas (SCC) with a strong expression of programmed death ligand 1 (PD-L1) in tumor cells. Therefore, we conducted this meta-analysis.MethodsWe performed a comprehensive research in PubMed, Embase and Cochrane databases up to September 30th, 2019. The effect size was hazard ratio (HR) with 95% confidence interval (CI) for overall survival (OS), cancer specific survival (CSS), disease free survival (DFS). The pooled odds ratio (OR) with 95%CI were used to assess the association between PD-L1 expression and clinicopathological features along with HPV status.ResultsA total of 2003 cases (944 anogenital and 1059 oropharynx SCC patients) were included. High PD-L1 expression in anogenital SCC cases were associated with advanced age (OR=1.63, 95%CI:1.04-2.58) and HPV negativity (OR=0.47,95%CI:0.31-0.71). Besides, PD-L1 positive anogenital SCC cases held a significant declined OS (HR=2.18, 95%CI:1.37-3.47) and CSS (HR=2.45, 95%CI:1.30-4.65). For oropharynx SCC, PD-L1 was more frequent in younger and HPV positive patients (OR=0.60, 95%CI:0.37-0.98; OR=3.01, 95%CI:1.78-5.09) and PD-L1 expression was relevant to better OS and DFS (HR=0.76, 95%CI:0.60-0.97; HR=0.50, 95%CI:0.33-0.75).ConclusionsThe meta-analysis demonstrated that in anogenital SCC, PD-L1 positivity had to do with a worse outcome, which might attribute to advanced age, higher tumor grade, lymph node metastasis and HPV negativity, while in oropharynx cancer, PD-L1expression was related to better prognosis for the reason that PD-L1 was less frequent in the aged and negative HPV status.

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Occurrence of metachronous second primary cancer in head and neck cancer survivors: A systematic review and meta‐analysis of the literature

Cited by 14 publications

References 78 publications

Endoscopic Screening for Second Primary Tumors of the Esophagus Among Head and Neck Cancer Patients

Endoscopic Screening for Second Primary Tumors of the Esophagus Among Head and Neck Cancer Patients

Single nucleotide polymorphisms and the risk of developing a second primary cancer among head and neck cancer patients: a systematic literature review and meta-analysis

PD-L1 expression in anogenital and oropharyngeal squamous cell carcinomas associated with different clinicopathological features, HPV status and prognosis: a meta-analysis

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