Occurrence of Multiple, Extensive and Pan Drug-Resistant Pseudomonas aeruginosa and Carbapenemase Production from Presumptive Isolates Stored in a Biobank at Ethiopian Public Health Institute

Addis, Tesfa; Araya, Shambel; Desta, Kassu

doi:10.2147/idr.s327652

Cited by 10 publications

(20 citation statements)

References 21 publications

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“…Accordingly, Ozman et al [226] purported that these types of drug resistance are responsible for several challenges in society and cause difficulties in treatment, encouraging the development of novel drugs by doctors. This can be explained by the fact that it is not easy to develop a standard therapeutic regimen to manage PDR infections in ill individuals [231].…”

Section: Extensively Drug-resistant (Xdr) and Pan-drug-resistant (Pdr...mentioning

confidence: 99%

A South African Perspective on the Microbiological and Chemical Quality of Meat: Plausible Public Health Implications

Manyi-Loh,

Lues

2023

Microorganisms

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Meat comprises proteins, fats, vitamins, and trace elements, essential nutrients for the growth and development of the body. The increased demand for meat necessitates the use of antibiotics in intensive farming to sustain and raise productivity. However, the high water activity, the neutral pH, and the high protein content of meat create a favourable milieu for the growth and the persistence of bacteria. Meat serves as a portal for the spread of foodborne diseases. This occurs because of contamination. This review presents information on animal farming in South Africa, the microbial and chemical contamination of meat, and the consequential effects on public health. In South Africa, the sales of meat can be operated both formally and informally. Meat becomes exposed to contamination with different categories of microbes, originating from varying sources during preparation, processing, packaging, storage, and serving to consumers. Apparently, meat harbours diverse pathogenic microorganisms and antibiotic residues alongside the occurrence of drug resistance in zoonotic pathogens, due to the improper use of antibiotics during farming. Different findings obtained across the country showed variations in prevalence of bacteria and multidrug-resistant bacteria studied, which could be explained by the differences in the manufacturer practices, handling processes from producers to consumers, and the success of the hygienic measures employed during production. Furthermore, variation in the socioeconomic and political factors and differences in bacterial strains, geographical area, time, climatic factors, etc. could be responsible for the discrepancy in the level of antibiotic resistance between the provinces. Bacteria identified in meat including Escherichia coli, Listeria monocytogenes, Staphylococcus aureus, Campylobacter spp., Salmonella spp., etc. are incriminated as pathogenic agents causing serious infections in human and their drug-resistant counterparts can cause prolonged infection plus long hospital stays, increased mortality and morbidity as well as huge socioeconomic burden and even death. Therefore, uncooked meat or improperly cooked meat consumed by the population serves as a risk to human health.

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Section: Extensively Drug-resistant (Xdr) and Pan-drug-resistant (Pdr...mentioning

confidence: 99%

A South African Perspective on the Microbiological and Chemical Quality of Meat: Plausible Public Health Implications

Manyi-Loh,

Lues

2023

Microorganisms

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“…Twenty seven isolates were identified as test candidates for carbapenemase enzyme production, where only 3/27 (11%) isolates were detected as carbapenemase enzyme producers. 4 …”

Section: Dear Editormentioning

confidence: 99%

Detection of Antibiotic Resistance Genes in Pseudomonas aeruginosa by Whole Genome Sequencing [Letter]

Idrus¹,

Sunarno²,

Rijal³

2022

IDR

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“…The utilization of carbapenems and the emergence carbapenem resistant P. aeruginosa is increased concomitantly in dramatic way throughout the different region of the world [ 12 , 13 ]. A significant increase in resistance of carbapenem to the gram negative bacilli including the P. aeruginosa was recorded which ranges from 30.1 to 74% [ 14 – 18 ]. To reduce the antibiotic resistance of such nosocomial infections, these must be investigated globally and interventions must be implemented.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of meropenem-resistant Pseudomonas Aeruginosa in Ethiopia: a systematic review and meta‑analysis

Gobezie,

Hassen,

Tesfaye

et al. 2024

Antimicrob Resist Infect Control

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Introduction Antimicrobial resistance (AMR) is a pressing global health concern, particularly pronounced in low-resource settings. In Ethiopia, the escalating prevalence of carbapenem-resistant Pseudomonas aeruginosa (P. aeruginosa) poses a substantial threat to public health. Methods A comprehensive search of databases, including PubMed, Scopus, Embase, Hinari, and Google Scholar, identified relevant studies. Inclusion criteria encompassed observational studies reporting the prevalence of meropenem-resistant P. aeruginosa in Ethiopia. Quality assessment utilized JBI checklists. A random-effects meta-analysis pooled data on study characteristics and prevalence estimates, with subsequent subgroup and sensitivity analyses. Publication bias was assessed graphically and statistically. Results Out of 433 studies, nineteen, comprising a total sample of 11,131, met inclusion criteria. The pooled prevalence of meropenem-resistant P. aeruginosa was 15% (95% CI: 10–21%). Significant heterogeneity (I2 = 83.6%) was observed, with the number of P. aeruginosa isolates identified as the primary source of heterogeneity (p = 0.127). Subgroup analysis by infection source revealed a higher prevalence in hospital-acquired infections (28%, 95% CI: 10, 46) compared to community settings (6%, 95% CI: 2, 11). Geographic based subgroup analysis indicated the highest prevalence in the Amhara region (23%, 95% CI: 8, 38), followed by Addis Ababa (21%, 95% CI: 11, 32), and lower prevalence in the Oromia region (7%, 95% CI: 4, 19). Wound samples exhibited the highest resistance (25%, 95% CI: 25, 78), while sputum samples showed the lowest prevalence. Publication bias, identified through funnel plot examination and Egger’s regression test (p < 0.001), execution of trim and fill analysis resulted in an adjusted pooled prevalence of (3.7%, 95% CI: 2.3, 9.6). Conclusion The noteworthy prevalence of meropenem resistance among P. aeruginosa isolates in Ethiopia, particularly in healthcare settings, underscores the urgency of implementing strict infection control practices and antibiotic stewardship. Further research is imperative to address and mitigate the challenges posed by antimicrobial resistance in the country.

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Occurrence of Multiple, Extensive and Pan Drug-Resistant Pseudomonas aeruginosa and Carbapenemase Production from Presumptive Isolates Stored in a Biobank at Ethiopian Public Health Institute

Cited by 10 publications

References 21 publications

A South African Perspective on the Microbiological and Chemical Quality of Meat: Plausible Public Health Implications

A South African Perspective on the Microbiological and Chemical Quality of Meat: Plausible Public Health Implications

Detection of Antibiotic Resistance Genes in Pseudomonas aeruginosa by Whole Genome Sequencing [Letter]

Prevalence of meropenem-resistant Pseudomonas Aeruginosa in Ethiopia: a systematic review and meta‑analysis

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