Occurrence of Multiple Myeloma Three Years After Successful Renal Transplantation

Howard, Andrew D.; Moore, Jack; Tomaszewski, Maria-Magdelena

doi:10.1016/s0272-6386(87)80049-5

Cited by 34 publications

(10 citation statements)

References 3 publications

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“…10,20,26 Seven showed no response, and all but one received chemotherapy. 10,24,27,29,35,36 The one nonresponder who did not receive chemotherapy was treated with only a reduction of immunosuppression. 10 One patient had stable disease, despite a lack of reduction of immunosuppression or treatment with chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Post-transplant plasma cell myeloma and polymorphic lymphoproliferative disorder with monoclonal serum protein occurring in solid organ transplant recipients

et al. 2004

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Post-transplant lymphoproliferative disorders are mostly Epstein-Barr virus-related, B-cell tumors that develop as a consequence of immunosuppressive therapy in recipients of solid organ or bone marrow transplants. These disorders range from reactive, polyclonal plasmacytic hyperplasia to those that are morphologically and genotypically indistinguishable from typical non-Hodgkin's lymphomas. Plasma cell myeloma occurring after solid organ transplantation is rare. We report three plasma cell myeloma post-transplant lymphoproliferative disorder cases and one polymorphic, monoclonal post-transplant lymphoproliferative disorder case associated with a monoclonal serum protein. All three plasma cell myeloma post-transplant lymphoproliferative disorder cases had clinical, radiologic, and pathologic features of conventional plasma cell myeloma. The one polymorphic post-transplant lymphoproliferative disorder case was associated with an IgM monoclonal serum protein and was morphologically indistinguishable from a lymphoplasmacytic lymphoma. Three of the four cases, including the one polymorphic post-transplant lymphoproliferative disorder case, were positive for Epstein-Barr virus encoded small RNA by in situ hybridization. One patient died of plasma cell myeloma posttransplant lymphoproliferative disorder. The remaining three patients are alive: two are completely free of posttransplant lymphoproliferative disorder, and one has shown partial response to therapy. We compare the clinicopathologic features of these cases with those in the literature.

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Section: Discussionmentioning

confidence: 99%

Post-transplant plasma cell myeloma and polymorphic lymphoproliferative disorder with monoclonal serum protein occurring in solid organ transplant recipients

et al. 2004

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“…The 2nd case was described by Radi et al [5] in a renal graft recipient who developed a squamous-cell carcinoma of the skin asso ciated with an IgG k multiple myeloma. The 3rd case of myeloma was more recently described by Howard et al [6]. Their patient presented progressive allograft dysfunc tion 3 years after transplantation from a related donor.…”

Section: Discussionmentioning

confidence: 93%

“…Howard et al [6] suggest that this rarity might be due to the relatively young age of transplant recipients.…”

Section: Discussionmentioning

confidence: 99%

Multiple Myeloma and AL Amyloidosis in a Renal Transplant Recipient

Aparicio¹,

Précigout²,

Reiffers³

et al. 1989

Nephron

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“…Howard et al . [12] described a patient in whom the diagnosis of multiple myeloma was confirmed following the histological demonstration of light chain nephropathy as the cause of graft dysfunction. In our case, the patient was presented with back pain, sciatica on right side without motor paralysis, and on evaluation had compression fracture of D4 vertebrae and tumor mass in iliac bone.…”

Section: Discussionmentioning

confidence: 99%

Plasma cell myeloma in a renal transplant recipient: A case report and review of literature

et al. 2011

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Post-transplant lymphoproliferative disorders are mostly B-cell neoplasms that develop as a consequence of immunosuppressive therapy. Plasma cell myeloma occurring after solid organ transplant is rare. We report here a case of plasma cell myeloma variant of post-transplant lymphoproliferative disorders developing after 15 months of live related renal transplant in a 41-year-old female. We compare clinicopathological features of this case with few cases reported in literature.

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Occurrence of Multiple Myeloma Three Years After Successful Renal Transplantation

Cited by 34 publications

References 3 publications

Post-transplant plasma cell myeloma and polymorphic lymphoproliferative disorder with monoclonal serum protein occurring in solid organ transplant recipients

Post-transplant plasma cell myeloma and polymorphic lymphoproliferative disorder with monoclonal serum protein occurring in solid organ transplant recipients

Multiple Myeloma and AL Amyloidosis in a Renal Transplant Recipient

Plasma cell myeloma in a renal transplant recipient: A case report and review of literature

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