Occurrence of nocturia is not mediated by nocturnal hypoxia length and severity in patients with sleep-disordered breathing

Finamore, Panaiotis; Scarlata, Simone; Laudisio, Alice; F, Galdi; Pipita, Maria Elena; Chiarella, Irene; Giua, Renato; Cortese, Livio; Rivera, Chiara; Incalzi, Raffaele Antonelli

doi:10.1016/j.sleep.2018.01.009

Cited by 10 publications

(8 citation statements)

References 27 publications

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“…According Finamore et al [26], they reported that nocturia is associated with intermittent desaturation (ODI3) rather than severity and length of hypoxia represented by T90. However, in this study, although there was no significant difference in logistic regression, a significant difference in T90 was found between the 2 groups with adjusted for age, hypertension, DM, and WHR.…”

Section: Discussionmentioning

confidence: 99%

Effect of Nocturnal Hypoxia on Nocturia in Patients With Obstructive Sleep Apnea

et al. 2019

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Purpose To identify the association between nocturia and obstructive sleep apnea (OSA), we compared results of polysomnography (PSG) with the presence or absence of nocturia in patients with suspected OSA. Methods Patients underwent PSG for suspected OSA. The International Prostate Symptom Score and quality of life (IPSS/QoL) questionnaire was evaluated to assess voiding symptoms that may affect sleep quality. The results of PSG were compared between patient groups with or without nocturia. Results In logistic regression analysis, age (odds ratio [OR], 1.052; P=0.004), diabetes mellitus (OR, 6.675; P<0.001), mean O 2 saturation (OR, 0.650; P=0.017), oxygen desaturation index (ODI) 3 (OR, 1.193; P=0.010), and ODI4 (OR, 1.136; P=0.014) affected nocturia independently among the OSA-suspected patients. Conclusions Hypoxia caused by OSA affects the incidence of nocturia. Less desaturated OSA patients with nocturia may require more urological evaluation and treatment for nocturia even after the correction of OSA.

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Section: Discussionmentioning

confidence: 99%

Effect of Nocturnal Hypoxia on Nocturia in Patients With Obstructive Sleep Apnea

et al. 2019

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“…Obesity is a major risk factor of OSAS [1,2,3,4,5,6,7], and both of these conditions impose adverse neurocognitive, mood, behavioral, cardiovascular, and metabolic consequences in both children and adults. In addition, as the awareness and consequently the frequency of diagnosing OSAS have increased, a large list of additional OSAS-associated morbidities has been reported, including chronic kidney disease, erectile dysfunction, ocular conditions, Alzheimer disease, nocturia, and even cancer in adults, while in children enuresis and bruxism are frequent adverse consequences [8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31]. Efforts are ongoing to develop new and more effective therapies for OSAS based on underlying mechanisms promoting upper airway collapsibility during sleep [32,33].…”

Section: Obstructive Sleep Apnea Syndrome (Osas) and Morbiditymentioning

confidence: 99%

Obstructive Sleep Apnea and Inflammation: Proof of Concept Based on Two Illustrative Cytokines

Kheirandish‐Gozal

Gozal

2019

IJMS

231

156

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Obstructive sleep apnea syndrome (OSAS) is a markedly prevalent condition across the lifespan, particularly in overweight and obese individuals, which has been associated with an independent risk for neurocognitive, behavioral, and mood problems as well as cardiovascular and metabolic morbidities, ultimately fostering increases in overall mortality rates. In adult patients, excessive daytime sleepiness (EDS) is the most frequent symptom leading to clinical referral for evaluation and treatment, but classic EDS features are less likely to be reported in children, particularly among those with normal body-mass index. The cumulative evidence collected over the last two decades supports a conceptual framework, whereby sleep-disordered breathing in general and more particularly OSAS should be viewed as low-grade chronic inflammatory diseases. Accordingly, it is assumed that a proportion of the morbid phenotypic signature in OSAS is causally explained by underlying inflammatory processes inducing end-organ dysfunction. Here, the published links between OSAS and systemic inflammation will be critically reviewed, with special focus on the pro-inflammatory cytokines tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6), since these constitute classical prototypes of the large spectrum of inflammatory molecules that have been explored in OSAS patients.

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“…Recent reviews have summarized the evidence supporting roles that pelvic ischemia and oxidative stress may play in lower urinary tract dysfunction (LUTD), including detrusor overactivity (DO)/overactive bladder (OAB) and detrusor underactivity (DU)/underactive bladder (UAB) 1‐3 . In addition, studies have shown that intermittent oxygen desaturations in individuals with sleep‐disordered breathing are associated with nocturia, 4 and oxidative stress due to sleep apnea has been linked with nocturia 5 . Furthermore, bladder blood flow has been demonstrated to be reduced in patients with bladder pain syndrome, 6 and oxidative stress is reportedly associated with interstitial cystitis 7 .…”

Section: Introductionmentioning

confidence: 99%

Are oxidative stress and ischemia significant causes of bladder damage leading to lower urinary tract dysfunction? Report from the ICI‐RS 2019

Speich¹,

Tarcan

Hashitani

et al. 2020

Neurourology and Urodynamics

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Several studies indicate that pelvic ischemia and oxidative stress may play a significant role in lower urinary tract dysfunction (LUTD), including detrusor overactivity (DO)/overactive bladder (OAB) and detrusor underactivity (DU)/underactive bladder (UAB). The present article addresses proposal 1: “Are oxidative stress and ischemia significant causes of bladder damage leading to LUTD?” from the 2019 International Consultation on Incontinence—Research Society (ICI‐RS) meeting. Bladder ischemia in animals and humans is briefly described, along with the proposed progression from ischemia to LUTD. Bladder ischemia is compared with ischemia of other organs, and the ongoing development of pelvic ischemia animal models is discussed. In addition, the distribution of blood within the bladder during filling and voiding and the challenges of quantification of blood flow in vivo are described. Furthermore, oxidative stress, including potential biomarkers and treatments, and challenges regarding antioxidant therapy for the treatment of LUTD are discussed. Finally, seven critical research questions and proposed studies to answer those questions were identified as priorities that would lead to major advances in the understanding and treatment of lower urinary tract symptoms (LUTS)/LUTD associated with pelvic ischemia and oxidative stress.

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Occurrence of nocturia is not mediated by nocturnal hypoxia length and severity in patients with sleep-disordered breathing

Cited by 10 publications

References 27 publications

Effect of Nocturnal Hypoxia on Nocturia in Patients With Obstructive Sleep Apnea

Effect of Nocturnal Hypoxia on Nocturia in Patients With Obstructive Sleep Apnea

Obstructive Sleep Apnea and Inflammation: Proof of Concept Based on Two Illustrative Cytokines

Are oxidative stress and ischemia significant causes of bladder damage leading to lower urinary tract dysfunction? Report from the ICI‐RS 2019

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