Occurrence of pharmaceuticals in seafood from two Brazilian coastal areas: Implication for human risk assessment

Mello, Flávia V.; Cunha, Sara C.; Fogaça, Fabíola Helena dos Santos; Alonso, Mariana B.; Torres, João Paulo Machado; Fernandes, José O.

doi:10.1016/j.scitotenv.2021.149744

Cited by 50 publications

(39 citation statements)

References 41 publications

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“…While 20-30% come from aquaculture, the remaining antibiotics come from the wastewater discharges of industries, hospitals and breeding practices [26,27]. Antibiotics and their metabolites are in fact eliminated through feces and urine and the conventional waste treatment systems are not able to fully eliminate these pharmaceutical compounds [28]. Wastewater treatment plants are important in the lifecycle of antibiotics, such that urban effluent outfalls constitute important sources of these antimicrobial pharmaceuticals into the environment.…”

Section: Antibiotics' Use and Their Presence In Aquatic Environmentmentioning

confidence: 99%

“…To date, four studies are reported in literature investigating the presence of antibiotics in bivalves collected around American coasts in order to evaluate the bioaccumulation of these emerging contaminants in these aquatic organisms and to estimate both environmental contamination and possible adverse effects in shellfish consumers [28,[56][57][58]. Klosterhaus et al (2013) analyzed mussels collected from five sites in San Francisco Bay during December 2009 and January 2010 for their antibiotic content.…”

Section: Occurrence Of Antibiotics In Bivalve Mollusks Harvested In Americamentioning

confidence: 99%

“…Results obtained by Dodder et al (2014) and Maruya et al (2014) suggest that lomefloxacin, and other investigated compounds other than antibiotics, should be included in bivalve monitoring programs, given the high detection frequency and concentrations found [57,58]. Mello et al (2022) investigated the occurrence of pharmaceuticals, including the antibiotic chloramphenicol that is prohibited for use in foods of animal origin. In this study, two Brazilian coastal areas were chosen as sampling points during July-August 2019: Sepetiba Bay and Parnaiba Delta River [28].…”

Section: Occurrence Of Antibiotics In Bivalve Mollusks Harvested In Americamentioning

confidence: 99%

“…Mello et al (2022) investigated the occurrence of pharmaceuticals, including the antibiotic chloramphenicol that is prohibited for use in foods of animal origin. In this study, two Brazilian coastal areas were chosen as sampling points during July-August 2019: Sepetiba Bay and Parnaiba Delta River [28]. Chloramphenicol was detected at concentrations ranging from values below the LOQ of the method (0.26 ng/g ww) to 0.5 ng/g ww.…”

Section: Occurrence Of Antibiotics In Bivalve Mollusks Harvested In Americamentioning

confidence: 99%

“…Chloramphenicol was detected at concentrations ranging from values below the LOQ of the method (0.26 ng/g ww) to 0.5 ng/g ww. Despite the low concentrations found, the determination of the prohibited antibiotic arouses the importance of monitoring consumed seafood in Brazil widely [28].…”

Section: Occurrence Of Antibiotics In Bivalve Mollusks Harvested In Americamentioning

confidence: 99%

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An Overview of Antibiotics as Emerging Contaminants: Occurrence in Bivalves as Biomonitoring Organisms

Baralla

Demontis

Dessì

et al. 2021

Animals

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Antibiotics are used for therapeutic and prophylactic purposes in both human and veterinary medicine and as growth promoting agents in farms and aquaculture. They can accumulate in environmental matrices and in the food chain, causing adverse effects in humans and animals including the development of antibiotic resistance. This review aims to update and discuss the available data on antibiotic residues, using bivalves as biomonitoring organisms. The current research indicates that antibiotics’ presence in bivalves has been investigated along European, American and Asian coasts, with the majority of studies reported for the last. Several classes of antibiotics have been detected, with a higher frequency of detection reported for macrolides, sulfonamides and quinolones. The highest concentration was instead reported for tetracyclines in bivalves collected in the North Adriatic Sea. Only oxytetracycline levels detected in this latter site exceeded the maximum residual limit established by the competent authorities. Moreover, the risk that can be derived from bivalve consumption, calculated considering the highest concentrations of antibiotics residues reported in the analyzed studies, is actually negligible. Nevertheless, further supervisions are needed in order to preserve the environment from antibiotic pollution, prevent the development of antimicrobial resistance and reduce the health risk derived from seafood consumption.

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Section: Antibiotics' Use and Their Presence In Aquatic Environmentmentioning

confidence: 99%

Section: Occurrence Of Antibiotics In Bivalve Mollusks Harvested In Americamentioning

confidence: 99%

Section: Occurrence Of Antibiotics In Bivalve Mollusks Harvested In Americamentioning

confidence: 99%

Section: Occurrence Of Antibiotics In Bivalve Mollusks Harvested In Americamentioning

confidence: 99%

Section: Occurrence Of Antibiotics In Bivalve Mollusks Harvested In Americamentioning

confidence: 99%

See 3 more Smart Citations

An Overview of Antibiotics as Emerging Contaminants: Occurrence in Bivalves as Biomonitoring Organisms

Baralla

Demontis

Dessì

et al. 2021

Animals

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20 years of research on the Guiana dolphin population of Sepetiba Bay, southeastern Brazil: What has changed?

Maciel,

Maricato,

Marqui

et al. 2023

Aquatic Conservation

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Despite the importance of coastal habitats for the provision of many ecosystem services, these areas are currently among the most impacted by human activities. Impacts on coastal ecosystems may affect many key species, such as the Guiana dolphin, which inhabits Sepetiba Bay in south‐eastern Brazil, a highly degraded environment owing to a human‐induced rapid environmental change. In this context, this study investigates the potential changes in the local Guiana dolphin behaviour, group structure, bioacoustics, site fidelity and habitat use over the past 20 years. For this, a historical database (1998–2007) was compared with current data on the local dolphin population (2017–2019). Between 2017 and 2019, the Guiana dolphins form significantly smaller groups (W = 3262.5, P > 0.001), spend more time foraging (61 vs. 10% in the past), emit whistles at a considerably lower rate (decreasing by 85.2%), have reduced site fidelity and now use a larger area. As Sepetiba Bay has been severely impacted by human activities in the recent past, with profound consequences for much of its biodiversity, the observed changes in dolphin behaviour are probably a consequence of habitat degradation and, in particular, of reduced prey availability. These findings have important implications for the management and conservation of the Guiana dolphin population of Sepetiba Bay. To break this human‐induced rapid environmental change, it will be essential to minimize the spatio‐temporal overlap of anthropogenic impacts, to avoid cumulative impacts. To mitigate anthropogenic impacts on the Guiana dolphins of Sepetiba Bay, it will be important to direct the following actions: (i) the regulation and control of anthropogenic noise; (ii) reduction and control of the release of chemical contaminants and organic effluents; (iii) more effective controls on vessel traffic within the areas used preferentially by the Guiana dolphin; and (iv) the implementation of measures to avoid overfishing and bycatch.

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Behavior of diclofenac from contaminated fish after cooking and in vitro digestion

Mello,

Marmelo,

Fogaça

et al. 2024

J Sci Food Agric

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BackgroundSeafood consumers are widely exposed to diclofenac due to the high contamination levels often present in aquatic organisms. It is a potential risk to public health due its endocrine disruptor properties. Limited information is available about diclofenac behavior after food digestion to enable a more realistic scenario of consumer exposure. This study aimed to evaluate cooking effects on diclofenac levels, and determine diclofenac bioaccessibility by an in vitro digestion assay, using commercial fish species (seabass and white mulle) as models. The production of main metabolite 4′‐hidroxydiclofenac was also investigated. Fish hamburguers were spiked at two levels (150 and 1000 ng. g−1) and submitted to three culinary treatments (roasting, steaming and grilling).ResultsThe loss of water seems to be increased the diclofenac levels after cooking, excepting in seabass with higher levels. The high bioaccessibility of diclofenac (59.1 to 98.3%) observed in both fish species indicates that consumers' intestine is more susceptible to absorb, which can be worrisome depending on the level of contamination. Contamination levels did not affect the diclofenac bioaccessibility in both species. Seabass, the fattest species, exhibited a higher bioaccessibility of diclofenac compared to white mullet. Overall, cooking decreased diclofenac bioaccessibility by up to 40% in seabass and 25% in white mullet. The main metabolite 4′‐hydroxydiclofenac was not detected after cooking or digestion.ConclusionThus, consumption of cooked fish, preferentially grilled seabass and steamed or baked white mullet are more advisible. This study highlights the importance to consider bioaccessibility and cooking in hazard characterization studies.This article is protected by copyright. All rights reserved.

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Occurrence of pharmaceuticals in seafood from two Brazilian coastal areas: Implication for human risk assessment

Cited by 50 publications

References 41 publications

An Overview of Antibiotics as Emerging Contaminants: Occurrence in Bivalves as Biomonitoring Organisms

An Overview of Antibiotics as Emerging Contaminants: Occurrence in Bivalves as Biomonitoring Organisms

20 years of research on the Guiana dolphin population of Sepetiba Bay, southeastern Brazil: What has changed?

Behavior of diclofenac from contaminated fish after cooking and in vitro digestion

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