Occurrence of plasmid-mediated fosfomycin resistance (fos genes) among Escherichia coli isolates, Portugal

Grilo, Teresa; Freire, Samanta; Miguel, Blanco; Martins, Luana Mota; Menezes, Maria Favila; Nordmann, Patrice; Poirel, Laurent; Sousa, Maria José Rego de; Aires-de-Sousa, Marta

doi:10.1016/j.jgar.2023.08.001

Cited by 4 publications

(1 citation statement)

References 33 publications

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“…In a multicentric study conducted in Italy, the mean resistance rate against fosfomycin was 9.7% (range 7.1–11.3), higher among ESBL-producing bacteria when compared with non-ESBL-producing strains (10.8% vs. 7.9%, respectively; P < 0.001) 31 . In a study conducted in Portugal, out of the 19,186 E. coli isolates, 100 were fosfomycin resistant (0.5%), out of which 15 carried a fos A-like gene (15%) 32 . In Egypt, a study found a high percentage of fosfomycin resistance (37/96; 38.5%), which was reported among uropathogenic E. coli isolates 33 .…”

Section: Discussionmentioning

confidence: 99%

In vitro susceptibility to fosfomycin in clinical and environmental extended-spectrum beta-lactamase producing and/or ciprofloxacin-non-susceptible Escherichia coli isolates

Ribeiro,

Bail,

Ito

et al. 2024

Rev. Inst. Med. trop. S. Paulo

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Extended-spectrum beta-lactamase producing and ciprofloxacin-non-susceptible Escherichia coli are clinical and environmental issues. We evaluated the susceptibility profile of fosfomycin in non-susceptible E. coli isolated from urine and the environment. We measured the activity of fosfomycin against 319 and 36 E. coli strains from urine and environmental isolates, respectively, collected from rivers. Fosfomycin resistance profiles were investigated using the minimal inhibitory concentration (MIC), according to the Clinical and Laboratory Standards Institute (CLSI) and the European Committee for Antimicrobial Susceptibility Testing (EUCAST) guidelines. Antibiotic susceptibility testing revealed that 5% and 6.6% of urine samples were non-susceptible to fosfomycin according to CLSI and EUCAST guidelines, respectively. The fosfomycin MIC50/90 was 0.5/4 mg/L. Of the 36 E. coli isolates from river water, 11.1% and 13,8% were non-susceptible to fosfomycin according to CLSI and EUCAST, respectively (range ≤0.25 ≥512 mg/L). All the isolates with MIC ≥512 mg/L for fosfomycin showed the fos A3 gene. Fosfomycin resistance was more frequent in the environment than in clinical samples.

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Section: Discussionmentioning

confidence: 99%