Occurrence of strongyloidiasis among patients with HTLV-1/2 seen at the outpatient clinic of the Núcleo de Medicina Tropical, Belém, State of Pará, Brazil

Furtado, Karen Cristini Yumi Ogawa; Costa, Carlos Araújo da; Ferreira, Louise de Souza Canto; Martins, Luisa Carí­cio; Linhares, Alexandre da Costa; Ishikawa, Edna Aoba Yassui; Batista, Evander de Jesus Oliveira; Sousa, Maísa Silva de

doi:10.1590/0037-8682-981-2013

Cited by 14 publications

(14 citation statements)

References 11 publications

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“…This association has been reported in Brazil by Furtado et al (17) . The synergistic effects of co-infection with HTLV and S. stercoralis, which have been demonstrated, suggest that co-infected patients exhibit elevated parasite burdens and HTLV-1 proviral loads (18) (19) (20) .…”

Section: S Stercoralis-s Stercoralispositive (N=167) Negative (N=133)supporting

confidence: 78%

Clinical conditions associated withintestinal strongyloidiasis in Rio de Janeiro, Brazil

Cabral

Iñiguez

Moreno

et al. 2015

Rev. Soc. Bras. Med. Trop.

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Introduction:Strongyloides stercoralis is a soil-transmitted helminth that produces an infection that can persist for decades. The relationships between certain clinical conditions and strongyloidiasis remains controversial. This study aims to identify the clinical conditions associated with intestinal strongyloidiasis at a reference center for infectious diseases in Rio de Janeiro, Brazil. Methods: The clinical conditions that were assessed included HIV/AIDS, HTLV infection, cardiovascular diseases, diabetes, obstructive respiratory diseases, viral hepatitis, tuberculosis, cancer, chronic renal disease, nutritional/metabolic disorders, psychiatric conditions, rheumatic diseases and dermatologic diseases. We compared 167 S. stercoralis-positive and 133 S. stercoralis-negative patients. Results: After controlling for sex (male/female OR = 2.29; 95% (CI): (1.42 -3.70), rheumatic diseases remained signifi cantly associated with intestinal strongyloidiasis (OR: 4.96; 95% CI: 1.34-18.37) in a multiple logistic regression model. With respect to leukocyte counts, patients with strongyloidiasis presented with signifi cantly higher relative eosinophil (10.32% ± 7.2 vs. 4.23% ± 2.92) and monocyte (8.49% ± 7.25 vs. 5.39% ± 4.31) counts and lower segmented neutrophil (52.85% ± 15.31 vs. 61.32% ± 11.4) and lymphocyte counts (28.11% ± 9.72 vs. 30.90% ± 9.51) than S. stercoralis-negative patients. Conclusions: Strongyloidiasis should be routinely investigated in hospitalized patients with complex conditions facilitate the treatment of patients who will undergo immunosuppressive therapy. Diagnoses should be determined through the use of appropriate parasitological methods, such as the Baermann-Moraes technique.

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Section: S Stercoralis-s Stercoralispositive (N=167) Negative (N=133)supporting

confidence: 78%

Clinical conditions associated withintestinal strongyloidiasis in Rio de Janeiro, Brazil

Cabral

Iñiguez

Moreno

et al. 2015

Rev. Soc. Bras. Med. Trop.

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“…Specifically in Brazil, in the State of Pará, infection by both HTLV-1/2 and by S. stercoralis is considered endemic. Due to this, the Center for Tropical Medicine (Núcleo de Medicina Tropical -NMT), of the Federal University of Pará (UFPA) undertook research in order to identify these two infections, and observed that in the 91 patients infected by HTLV, the frequency of S. stercoralis was 14.3% (n = 6) in patients infected with HTLV-1 and 11.1% (n = 2) among patients infected by HTLV-2 [13]. The same question was studied by Satoh, et al [14], in Japan, in which 31 patients were diagnosed as carrying HTLV-1.…”

Section: Resultsmentioning

confidence: 99%

“…These results reveal that infection by HTLV-1 reduced sensitivity for detection of IgE-specific S. stercoralis, the immediate hypersensitivity reaction and the sensitivity of these tests in the diagnosis of strongyloidiasis, leading to delay in diagnosis and increasing the possibility of more severe cases of coinfection. As a result of this, immunological tests were developed with the aim of increasing the specificity of S. stercoralis antibodies, both in blood tests and immediate hypersensitivity tests, so as to allow better diagnosis, bearing in mind the severity and incidence of the disease [13].…”

Section: Resultsmentioning

confidence: 99%

The Influence of Human T-Lymphotropic Virus 1 on Patients Coinfected by the Helminth Strongyloides stercoralis

Rodrigues¹,

Felipe²,

Arruda³

et al. 2019

Int J Trop Dis

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Strongyloides stercoralis is the helminth which causes strongyloidiasis, a neglected disease, with a global prevalence estimated at 60 million people infected, principally in tropical regions. The parasite's proliferation occurs mainly in immunosuppressed hosts, in particular, patients carrying Human T-lymphotropic virus 1 (HTLV-1), which is responsible for the infection of cells of the immune system. As a result, we aimed to identify and discuss clinical and pathological aspects of infection by S. stercoralis in patients carrying HTLV-1. This is an exploratory study, of the literature review type. The search was undertaken in the PubMed, Scielo, Web of Science, Science Direct and Biblioteca Virtual emSaúde (BVS) databases in August 2016. The criteria for the inclusion of articles were: Language, published in the last 20 years, and to be relevant to the guiding question. After reading of the titles, 60 articles were excluded, and after reading of the abstracts, a further 70. Of the 56 articles remaining, 16 were excluded after reading the article in full. After analysis of the material, only 40 studies met the criteria established. The studies showed that this type of coinfection is found in the same specific population groups which are vulnerable to the diseases, as well as immunomodulation of the Th2 pattern, promoted by the presence of S. stercoralis and the difficulties related to the diagnosis of Strongyloidiasis. It is concluded that it is necessary to screen for HTLV-1in cases of infection by S. stercoralis, so as to initiate fast and efficient treatment against this coinfection.

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“…As limitações nas realizações dos exames de pesquisa de S. stercoralis e flower cell ocorreram pela ausência dos materiais (fezes e sangue, respectivamente) dos portadores que, mesmo com a devida orientação, não tiveram interesse em retornar e prosseguir com os exames, revelando assim uma baixa frequência nesta pesquisa. A associação da coinfecção do S. stercoralis com o HTLV-1 foi demonstrada nos portadores da infecção atendidos no NMT 28 , os quais podem desenvolver estrongiloidíase crônica e promover maior perfil clínico de doenças relacionadas à proliferação dos linfócitos T.…”

Section: Discussionunclassified

Importância das ações de extensão universitária na prevenção de infecções e doenças associadas ao vírus linfotrópico-T humano

Coelho

Nobre

Silva

et al. 2018

Revista Pan-Amazônica de Saúde

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Occurrence of strongyloidiasis among patients with HTLV-1/2 seen at the outpatient clinic of the Núcleo de Medicina Tropical, Belém, State of Pará, Brazil

Cited by 14 publications

References 11 publications

Clinical conditions associated withintestinal strongyloidiasis in Rio de Janeiro, Brazil

Clinical conditions associated withintestinal strongyloidiasis in Rio de Janeiro, Brazil

The Influence of Human T-Lymphotropic Virus 1 on Patients Coinfected by the Helminth Strongyloides stercoralis

Importância das ações de extensão universitária na prevenção de infecções e doenças associadas ao vírus linfotrópico-T humano

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