Occurrence of systemic hypertension in dogs with acute kidney injury and treatment with amlodipine besylate

Geigy, Caroline; Schweighauser, Ariane; Doherr, Marcus G.; Francey, Thierry

doi:10.1111/j.1748-5827.2011.01067.x

Cited by 21 publications

(16 citation statements)

References 30 publications

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“…The prevalence of increased blood pressure in this population of uremic cats was generally lower than reported for dogs with AKI and is in accordance with previously published reports of blood pressure in cats with CKD . Fifty‐five percent of cases were anuric.…”

Section: Discussionsupporting

confidence: 90%

A Retrospective Study of Acute Kidney Injury in Cats and Development of a Novel Clinical Scoring System for Predicting Outcome for Cats Managed by Hemodialysis

Segev

Nivy

Kass

et al. 2013

Veterinary Internal Medicne

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Background: Information regarding acute kidney injury (AKI) in cats is limited, and there are no reliable tools to objectively assess disease severity and predict outcome.Objectives: To assess clinical signs, clinicopathologic abnormalities, etiology, and outcome of cats with AKI, and to develop models using clinical metrics and empirically derived scores to predict outcome.Animals: One hundred and thirty-two client-owned cats. Methods: Retrospective study. Bivariate logistic regression analyses were performed to identify variables predictive of 30-day survival. Continuous variables outside the reference range were divided into quartiles to yield quartile-specific odds ratios (OR) for survival. Models were developed incorporating weighting factors assigned to each quartile based on the OR. A predictive score for each model was calculated for each cat by summing all weighting factors. A second, multivariable logistic regression model was created from actual values of the same variables. Receiver operating characteristic curve analyses were performed to determine the models' performance. Models were further tested using a subset of cases not used in initial assessment.Results: Fifty five of 132 cats (42%) remained dialysis-independent for at least 30 days after discharge, and the remaining 77 cats either died (n = 37, 28%) or were euthanized (n = 40, 30%). The most common etiology was ureteral obstruction (n = 46, 35%). Higher scores were associated with decreased probability of survival (P < .001). Models correctly classified outcomes in 75-77% of the cases and 84-89% of the cases in the subsequent evaluation.Conclusions and Clinical Importance: Models can provide objective guidance in assessing AKI prognosis and severity, but should be validated in other cohorts of cats.

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Section: Discussionsupporting

confidence: 90%

A Retrospective Study of Acute Kidney Injury in Cats and Development of a Novel Clinical Scoring System for Predicting Outcome for Cats Managed by Hemodialysis

Segev

Nivy

Kass

et al. 2013

Veterinary Internal Medicne

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“…Two university clinics were involved: the internal medicine service of the JLU and the Small Animal Clinic of the Vetsuisse Faculty of the University of Bern (VFUB). Renal azotemia was defined as a serum creatinine concentration >1.4 mg/dL (upper laboratory reference value) and serum urea concentration >54 mg/dL (upper reference value) persisting at least 24 hours after correction of prerenal factors together with a urine specific gravity <1.025 . If no initial urine was available, response to fluid therapy was used to determine if a dog had prerenal azotemia.…”

Section: Methodsmentioning

confidence: 99%

“…All dogs with leptospirosis were presented to the VFUB. Dogs were diagnosed with leptospirosis based on a positive PCR on urine, a 4‐fold titer increase in paired microagglutination tests (MAT), a single MAT titer ≥1 : 800 for nonvaccinal serovars or a single MAT titer ≥1 : 3,200 for vaccinal serovars as previously published . Dogs that were suspected to have leptospirosis based on laboratory results and clinical course but died before diagnosis could be proven were considered not to have leptospirosis (n = 4).…”

Section: Methodsmentioning

confidence: 99%

Plasma and Urine Neutrophil Gelatinase–Associated Lipocalin (NGAL) in Dogs with Acute Kidney Injury or Chronic Kidney Disease

Steinbach

Weis

Schweighauser

et al. 2014

Veterinary Internal Medicne

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BackgroundNeutrophil gelatinase–associated lipocalin (NGAL) is a protein that is used in human medicine as a real‐time indicator of acute kidney injury (AKI).HypothesisDogs with AKI have significantly higher plasma NGAL concentration and urine NGAL‐to‐creatinine ratio (UNCR) compared with healthy dogs and dogs with chronic kidney disease (CKD).Animals18 healthy control dogs, 17 dogs with CKD, and 48 dogs with AKI.MethodsOver a period of 1 year, all dogs with renal azotemia were prospectively included. Urine and plasma samples were collected during the first 24 hours after presentation or after development of renal azotemia. Plasma and urine NGAL concentrations were measured with a commercially available canine NGAL Elisa Kit (Bioporto® Diagnostic) and UNCR was calculated. A single‐injection plasma inulin clearance was performed in the healthy dogs.ResultsMedian (range) NGAL plasma concentration in healthy dogs, dogs with CKD, and AKI were 10.7 ng/mL (2.5–21.2), 22.0 ng/mL (7.7–62.3), and 48.3 ng/mL (5.7–469.0), respectively. UNCR was 2 × 10−8 (0–46), 1,424 × 10−8 (385–18,347), and 2,366 × 10−8 (36–994,669), respectively. Dogs with renal azotemia had significantly higher NGAL concentrations and UNCR than did healthy dogs (P < .0001 for both). Plasma NGAL concentration was significantly higher in dogs with AKI compared with dogs with CKD (P = .027).Conclusions and Clinical ImportancePlasma NGAL could be helpful to differentiate AKI from CKD in dogs with renal azotemia.

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“…) and has been described in dogs with AKI (Geigy et al . ). However, the prevalence of SH in feline AKI patients is currently unknown.…”

Section: Introductionmentioning

confidence: 97%

Systemic hypertension in cats with acute kidney injury

Cole

Jepson

Humm

2017

J of Small Animal Practice

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Occurrence of systemic hypertension in dogs with acute kidney injury and treatment with amlodipine besylate

Abstract: Results of this study reveal that systemic hypertension is common in canine acute kidney injury and that treatment with amlodipine is beneficial in reducing systemic hypertension. The potential effect of amlodipine on global outcome requires prospective assessment.

Cited by 21 publications

References 30 publications

A Retrospective Study of Acute Kidney Injury in Cats and Development of a Novel Clinical Scoring System for Predicting Outcome for Cats Managed by Hemodialysis

A Retrospective Study of Acute Kidney Injury in Cats and Development of a Novel Clinical Scoring System for Predicting Outcome for Cats Managed by Hemodialysis

Plasma and Urine Neutrophil Gelatinase–Associated Lipocalin (NGAL) in Dogs with Acute Kidney Injury or Chronic Kidney Disease

Systemic hypertension in cats with acute kidney injury

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