Occurrence of Thrombocytopenia in Plasmodium vivax Malaria

Rodríguez‐Morales, Alfonso J.; Sánchez, Elia; Vargas, Miguel; Piccolo, Carmelina; Colina, Rosa; Arria, Melissa; Franco‐Paredes, Carlos

doi:10.1086/430837

Cited by 46 publications

(24 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In our study we found moderate and severe thrombocytopenia to be statistically significant among P. vivax malaria patients and this observation supports previous reports in isolated literature pertaining to thrombocytopenia in vivax malaria [19,20,21]. Thrombocytopenia has been postulated to occur secondary to peripheral destruction, splenic sequestration, and platelet consumption secondary to DIC, but none of our patients showed any bleeding tendencies despite very low platelet counts.…”

Section: Discussionsupporting

confidence: 90%

Hide and seek: hematological aspects of malaria – a developing country perspective

Haroon

Fazel

Naeem

et al. 2013

J Infect Dev Ctries

View full text Add to dashboard Cite

Introduction: Malaria, a major problem in tropical climates, presents with various hematological aberrations. We aimed to assess whether complete blood indices would increase the probability of malaria in patients with acute febrile illness. Methodology: Between February 2009 and December 2010, we conducted a study involving 824 consenting consecutive patients older than 12 years with a confirmed diagnosis of malaria based on thick and thin blood films. A detailed history and physical examination were completed on all patients before inclusion. Complete blood counts and detection of Plasmodium species were also performed as well as liver function tests, prothrombin time, reticulocyte counts, and parasite load. All data was analysed using SPSS 16.0 and percentages were calculated. Results: Out of 824 patients, 616 (75%) were male and 208 (25%) were female with an age range of 18 to 55 years (33.2 ± 8.3). Out of 87% thrombocytopenic patients, 66% were affected with Plasmodium falciparum and 21% with Plasmodium vivax. In patients with P. falciparum, thrombocytopenia was mild (16%), moderate (43%) and severe (7%), while in P. vivax patients thrombocytopenia was mild (10%) and moderate (9%). Thrombocytopenia was moderate in the mixed cases (2%). Anemia was seen in 71% and normal leucocyte counts were observed in 79% of the cases. Normal differential leucocytes counts were seen as follows: eosinophils in 80%, neutrophils in 93%, lymphocytes in 85%, monocytes in 97%, and basophils in 100%. Conclusion: Blood indices should be included in patient evaluations as various hematological aberrances can lead to the diagnosis of malaria.

show abstract

Section: Discussionsupporting

confidence: 90%

Hide and seek: hematological aspects of malaria – a developing country perspective

Haroon

Fazel

Naeem

et al. 2013

J Infect Dev Ctries

View full text Add to dashboard Cite

show abstract

“…In this tropical epidemiological scenario, clinical studies addressing that topic would also be useful, given that few studies in the country have assessed the epidemiology of severe P. vivax malaria [11,32], which has been largely documented and reported in other countries of Latin America, such as Venezuela [33][34][35] and Brazil [36][37][38], as well in Asia [39][40][41].…”

Section: Discussionmentioning

confidence: 99%

Mapping malaria in municipalities of the Coffee Triangle region of Colombia using Geographic Information Systems (GIS)

Rodríguez‐Morales

Orrego-Acevedo

Zambrano-Muñoz

et al. 2015

Journal of Infection and Public Health

View full text Add to dashboard Cite

Geographical Information Systems (GIS) have been used extensively for the development of epidemiological maps of malaria but not in the Coffee Triangle region of Colombia, endemic for P. vivax, P. falciparum and P. malariae. Surveillance case data (2007-2011) were used to estimate annual incidence rates per Plasmodium spp. (cases/100,000 pop) to develop the first malaria maps in the 53 municipalities of this region (departments Caldas, Quindío, Risaralda). The GIS software used was Kosmo Desktop 3.0RC1(®). Thirty thematic maps were developed according to the municipalities, years, parasite etiology, and uncomplicated and complicated cases. A total of 6582 cases were reported (6478 uncomplicated and 104 complicated, 77.8% Risaralda), for a cumulated rate of 269.46 cases/100,000 pop. Among uncomplicated cases, 5722 corresponded to P. vivax (234.25 cases/100,000 pop), 475 to P. falciparum (19.45 cases/100,000 pop), 8 to P. malariae (0.33 cases/100,000 pop) and 273 mixed (P. falciparum/P. vivax) (11.18 cases/100,000 pop). The highest rate reported was in the more undeveloped and rural municipality of Risaralda (Pueblo Rico, 57.7 cases/1000 pop, 2009). The burden of disease was concentrated in one department (>75% of the region). The use of GIS-based epidemiological maps helps to guide decision-making for the prevention and control of this public health problem that still represents a significant issue in the region and the country, particularly in children.

show abstract

“…The patient presented here was treated for his malaria with 1 g atovaquone/400 mg proguanil hydrochloride (Malarone, GlaxoSmithKline; Research Triangle Park, NC) daily for 3 consecutive days, along with primaquine 30 mg base daily for 14 days, and he had a prompt clinical response. His exceptionally profound thrombocytopenia was attributed to immune-mediated thrombocytopenic purpura, which is a known complication of malaria (although more typically P. falciparum and, to a lesser extent, P. vivax 28 ), and his platelet count rapidly normalized after treatment with intravenous immune globulin.…”

Section: Resultsmentioning

confidence: 99%

Use of qPCR and Genomic Sequencing to Diagnose Plasmodium ovale wallikeri Malaria in a Returned Soldier in the Setting of a Negative Rapid Diagnostic Assay

Cohen

Feghali²,

Alemayehu³

et al. 2013

The American Society of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

Abstract. Plasmodium ovale is one of several clinically relevant malaria species known to cause disease in humans. However, in contrast to Plasmodium falciparum and Plasmodium vivax, which are responsible for most cases of human malaria, P. ovale has a wide distribution but low prevalence in tropical regions. Here, we report the case of a soldier returning from Liberia with P. ovale wallikeri malaria. This case highlights the limitations of both microscopy and the malaria rapid diagnostic test for diagnosing infection with P. ovale and for distinguishing P. ovale wallikeri from P. ovale curtisi. To our knowledge, this is the first case report in which quantitative real-time polymerase chain reaction amplification using the Cytochrome B gene, coupled with genomic sequencing of the potra locus, was used for definitive diagnosis of P. ovale wallikeri malaria.

show abstract

Occurrence of Thrombocytopenia in Plasmodium vivax Malaria

Cited by 46 publications

References 19 publications

Hide and seek: hematological aspects of malaria – a developing country perspective

Hide and seek: hematological aspects of malaria – a developing country perspective

Mapping malaria in municipalities of the Coffee Triangle region of Colombia using Geographic Information Systems (GIS)

Use of qPCR and Genomic Sequencing to Diagnose Plasmodium ovale wallikeri Malaria in a Returned Soldier in the Setting of a Negative Rapid Diagnostic Assay

Contact Info

Product

Resources

About