Occurrence of tinnitus and peripheral sensory neuropathy in women during chemotherapy treatment of breast cancer

Abstract

Objective: To analyze the occurrence of tinnitus and peripheral sensory neuropathy in women during breast cancer chemotherapy. Methods: This is a retrospective analytical study with a quantitative approach, performed in medical records of an oncology outpatient service between February 2014 and February 2015, using the toxicities scores of Common Terminology Criteria for Adverse Events (CTCAE). Results: Considering 181 patients with breast cancer who met the inclusion criteria, 49.2% reported tinnitus at some point of the treatment, while 65.1% peripheral sensory neuropathy. In both conditions, the predominant severity score was grade 1, with frequencies of 23.8% and 33.1%, respectively. A significant, positive and weak correlation was observed between the severity of tinnitus and peripheral sensory neuropathy (ρ = 0.325 and p = 0.001), as well as very weak between the number of complete cycles of chemotherapy and tinnitus (ρ = 0.195 and p = 0.009) and neuropathy peripheral sensory (ρ = 0.237 and p = 0.002). Conclusions: Tinnitus and peripheral sensory neuropathy were frequent toxicities during chemotherapy treatment of breast cancer, and both manifested with low severity/functional impact in most participants.

Epidemiological Profile and Trends of Breast Cancer in the Municipalities of Belém and Ananindeua, Pará State, Amazon

“…Infiltrating ductal carcinoma is the most common histological type, comprising between 80 and 90% of all cases [15]. As well as this study, other studies corroborate the MS, which evidences the presence of invasive ductal carcinoma in one of the breasts in more than 80% of cases [16,[17][18].…”