Occurrence of vancomycin-resistant Staphylococcus aureus in the oral cavity of patients with dental caries

Vellappally, Sajith; Kheraif, Abdulaziz A. Al; Ramakrishnaiah, Ravikumar; AlQahtani, Amer; Dalati, Mohamad Hani Nouri; Anil, Sukumaran; Khan, Aftab Ahmed; Varma, P. R. Harikrishna

doi:10.1556/030.64.2017.033

Cited by 20 publications

(12 citation statements)

References 17 publications

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“…In some cases, teicoplanin can become an alternative to vancomycin because of the low incidence of adverse effects like nephrotoxicity and remains active against some vancomycin-resistant strains, such as vanB -type vancomycin-resistant strains. 6 , 7 In addition to vancomycin and teicoplanin, linezolid (an oxazolidinone antibiotic) and daptomycin (a cyclic lipopeptide antibiotic) were also last resort antibiotics to treat MRSA infections.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Activity of Vancomycin, Teicoplanin, Linezolid and Daptomycin Against Methicillin-Resistant Staphylococcus aureus Isolates Collected from Chinese Hospitals in 2018–2020

Xu¹,

Wang²,

Zhao³

et al. 2021

IDR

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Introduction Vancomycin, teicoplanin, linezolid and daptomycin are four major antibacterials used for methicillin-resistant Staphylococcus aureus (MRSA) infection treatment. However, with the increasing failure of clinical MRSA anti-infective treatment, it is urgent to investigate the status of MRSA sensitivity to these four drugs. Methods In the present study, 407 non-duplicated MRSA isolates from 6 provinces in China were collected from January 2018 to August 2020. The minimum inhibitory concentrations (MICs) of vancomycin, teicoplanin, linezolid and daptomycin were determined by broth microdilution method, and their MIC50, MIC90, and geometric mean MIC were calculated. Results All 407 MRSA strains were sensitive to these four antibacterials. MIC range of vancomycin, teicoplanin, linezolid and daptomycin was 0.25 to 2 mg/L, 0.125 to 4 mg/L, 0.25 to 4 mg/L and 0.06 to 1 mg/L, respectively. Between 2018 and 2020, there was no “MIC creep” in vancomycin, teicoplanin and daptomycin. The geometric mean MIC of linezolid was not increased, but both MIC50 and MIC90 in 2019 and 2020 MRSA isolates were higher than 2018 isolates. Conclusion All MRSA isolates remained sensitivity to vancomycin, teicoplanin, linezolid and daptomycin. The linezolid MIC50 and MIC90 increased have been found in this study.

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Section: Introductionmentioning

confidence: 99%

In Vitro Activity of Vancomycin, Teicoplanin, Linezolid and Daptomycin Against Methicillin-Resistant Staphylococcus aureus Isolates Collected from Chinese Hospitals in 2018–2020

Xu¹,

Wang²,

Zhao³

et al. 2021

IDR

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“…Because the arbitrary use of antibiotics is a typical practice, hospital environments are not clean enough and crowding of patients and health workers supports the spread of infectious germs including S. aureus 13 . The potential presence of S. aureus is especially important in dental infections due to its increased resistance 13,14 . Therefore it is very logical to check the status of the microbial resistance against the commonly used antibiotics for the treatment of dental infections that occur by S. aureus.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Staphylococcus Aureus in Dental Infections and the Occurrence of Mrsa in Isolates

et al. 2020

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Objectives: Staphylococcus aureus is an opportunist that causes systemic infections and dental infections in the human being body. This organism increases its resistance to many categories of antibiotics all day and turn out to be more resistant, and this led to a growing feeling of concern in this era. Given this fact, the aims of this study were to determine the frequency of S. aureus in oral infections and to determine the prevalence of MRSA strains and the sensitivity of isolated S. aureus to antibiotics, in patients who attended dental clinics in major public hospitals and private clinics in the city of Sana'a-Yemen. Subjects and methods: The study was conducted for a year, early in December 2018 and ending in November 2019. The study included 296 patients, 153 male and 143 female, ages 5 to 65, with an average age of 36.2 years. Demographic and clinical data were collected in questionnaire, then pus or oral swabs were collected from patients, cultivated, isolated and identified by standard laboratory techniques. MRSA was ascertained by means of the method of disc diffusion to 1µg of oxicillin disc and 5 µg of methacillin disc; an antimicrobial sensitivity test was carried out by disc diffusion method of selected antibiotics.The oral infections include dental abscesses, periodontal abscesses, gingivitis, periodentitis, dental caries, pulpitis and oral thrush. Results: Of a total of 296 cultured pus and swabs, only 217 produced a positive culture (73.3%). Gram-positive bacteria formed 67.4% of the total isolates where S. aureus was the predominant pathogen (43.1%). The prevalence of MRSA was 23.5%. There was a higher rate of antibiotic resistance tested in MRSA isolates compared to a lower rate of resistance in MSSA as well as 22.2% of MRSA isolates were vancomycin resistant, while only 11.4% of MSSA were vancomycin resistant. Conclusion: It can be concluded, S. aureus was the most widespread isolate in dental infections, high rate of MRSA, the appearance of S. aureus isolates resistant to vancomycin and other broad choice of antibiotics have raised MRSA in oral infections into a multi-drug-resistant, making it more and more hazardous in oral infections. Consistent assessment of oral associated infections and observing the pattern of antibiotic sensitivity and strict drug policy for antibiotics are recommended. Peer Review History: Received 16 April 2019; Revised 2 May; Accepted 12 May, Available online 15 May 2020 UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 8.0/10 Reviewer(s) detail: Name: Dr. Mohamed Awad Mousnad Affiliation: Faculty of Pharmacy, International University of Africa (IUA), Khartoum, Sudan E-mail: m_abdalaziz@yahoo.com Name: Dr. George Zhu Affiliation: Tehran University of Medical Sciences, Tehran, Iran E-mail: sansan4240732@163.com Comments of reviewer(s): Similar Articles: PREVALENCE OF METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) AND ANTIMICROBIAL SUSCEPTIBILITY PATTERNS AT A PRIVATE HOSPITAL IN SANA'A, YEMEN PREVALENCE, ANTIMICROBIAL SUSCEPTIBILITY PATTERN AND RISK FACTORS OF MRSA ISOLATED FROM CLINICAL SPECIMENS AMONG MILITARY PATIENTS AT 48 MEDICAL COMPOUND IN SANA'A CITY-YEMEN

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“…Because, indiscriminate use of antibiotics being a typical practice, hospital environments are not sufficiently clean as well as congestion of patients and attendants support spread of the infectious agents including S. aureus (Khan et al, 2007). The possible presence of S. aureus is particularly important in dental caries because of its increased resistance (Vellappally et al, 2017). So it is very logical to check the status of microbial resistance against commonly used antibiotics for the treatment of dental infections occurred by S. aureus.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Staphylococcus aureus isolated from human dental infection

Das¹,

Sabuj²,

Haque³

et al. 2019

Afr. J. Microbiol. Res.

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Staphylococcus aureus is an opportunistic pathogen causing dental infection and systemic infections in human body. This organism decreases susceptibility to several types of antibiotics every day and becomes more resistant which is a growing sense of concern in this era. Considering this fact, the study was attempted to characterize the S. aureus from human dental infection and to determine the antibiogram profile of isolates. Sixty four (64) samples were collected from the patients with dental infection who visited different dental clinics and hospitals in Mymensingh, Bangladesh for treatment. Isolation and identification of S. aureus were conducted by using cultural, morphological, and biochemical characteristics. Polymerase chain reaction was performed for final confirmation of S. aureus followed by detection of methicillin resistant S. aureus (MRSA) targeting mecA and mecC genes. Antibiotic susceptibility test of isolated bacteria was tested against seven antibiotics by disk diffusion methods. Forty isolates among 64 samples were found positive for S. aureus based on cultural characteristics. Among them 30 isolates were found positive in coagulase test. Depending on the result of coagulase test, all the 30 isolates were subjected to antibiotic sensitivity test and among them 25 were 100% resistant to penicillin, ampicillin and amoxicillin. All the 25 isolates were subjected to polymerase chain reaction (PCR) to identify methicillin resistant gene mecA and mecC. Eight isolates were positive for mecA gene while no isolates were positive for mecC. The present findings conclude that S. aureus is prevalent in dental infections and contain methicillin resistant genes.

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Occurrence of vancomycin-resistant Staphylococcus aureus in the oral cavity of patients with dental caries

Cited by 20 publications

References 17 publications

In Vitro Activity of Vancomycin, Teicoplanin, Linezolid and Daptomycin Against Methicillin-Resistant Staphylococcus aureus Isolates Collected from Chinese Hospitals in 2018–2020

In Vitro Activity of Vancomycin, Teicoplanin, Linezolid and Daptomycin Against Methicillin-Resistant Staphylococcus aureus Isolates Collected from Chinese Hospitals in 2018–2020

Prevalence of Staphylococcus Aureus in Dental Infections and the Occurrence of Mrsa in Isolates

Characterization of Staphylococcus aureus isolated from human dental infection

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