Occurrence of Vitamin D Deficiency in Pediatric Patients at High Risk in West Virginia

Robinson, Christy; Chiang, Myra; Thompson, Stephanie; Sondike, Stephen B.

doi:10.1097/smj.0b013e3182675e8a

Cited by 13 publications

(5 citation statements)

References 15 publications

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“…This has been found in both ORIGINAL RESEARCH healthy adolescent-aged children and adolescents with CF (10,12,39). One would speculate change in dietary habits, such as decreased milk and increased soda consumption.…”

Section: Discussionmentioning

confidence: 96%

Vitamin D Deficiency Is Associated with Pulmonary Exacerbations in Children with Cystic Fibrosis

et al. 2014

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Rationale: Recent literature suggests vitamin D has an effect on lung function and on the lung's ability to fight infection, both important in the cystic fibrosis (CF) population as predictors of morbidity and mortality.Objectives: Our study assessed associations between vitamin D and % predicted lung function, pulmonary exacerbations, and first Pseudomonas aeruginosa infection in children with CF. We hypothesized that children with CF who have 25-hydroxy vitamin D (25-OHD) levels less than 30 mg/L would have lower % predicted lung function and more pulmonary exacerbations than those with 25-OHD greater than or equal to 30 mg/L. Measurements and Main Results:The prevalence of vitamin D deficiency and insufficiency increased slowly through adolescence. The rate of exacerbations for the deficient vitamin D group, aged 15 to 18 years, was 13.1 per 10 patient-years, significantly higher than 4.3 per 10 patient-years for the insufficient and sufficient vitamin D groups (P , 0.05), which were not significantly different There were no differences between vitamin D groups in pulmonary function or incidence of first P. aeruginosa infection, which was about 2 per 10 patient-years.Conclusions: Higher 25-OHD levels in children with CF were associated with lower rates of pulmonary exacerbations and, in adolescents, higher FEV 1 .

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Section: Discussionmentioning

confidence: 96%

Vitamin D Deficiency Is Associated with Pulmonary Exacerbations in Children with Cystic Fibrosis

et al. 2014

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“…Even though in the non-obese populations, BMI and percentage body fat content were inversely related to the serum 25(OH)D concentrations 12 , 13 . Moreover, women and children with vitamin D deficiency had higher rates of obesity than those with non-deficient vitamin D level 14 . In a randomized controlled trial for calcium plus vitamin D supplementation, a significantly greater decrease in fat mass loss was observed in the calcium plus vitamin D supplementation group than in the control group, although there was no significant difference in body weight change between groups 15 .…”

Section: Introductionmentioning

confidence: 97%

The effect of maternal vitamin D deficiency during pregnancy on body fat and adipogenesis in rat offspring

Wen

Qin

Wang

et al. 2018

Sci Rep

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To evaluate the effects of maternal vitamin D deficiency on body fat and adipogenesis in offspring rats, and explore the potential mechanism, we constructed a vitamin D deficient rat model and performed metabolic activity evaluation, body fat monitoring, biochemical analysis, adipogenesis assay, methylation microarray and RNA-seq for their offspring rats. We found the weight of vitamin D deficient (VDD) offspring was gradually higher than that of control (CLT) offspring, and the difference was significant since 10 weeks old. When compared with CTL offspring, the 24 h heat production, peak blood glucose, adipose tissue volume and blood lipid indexes were significantly increased in VDD offspring at 14 weeks old. Moreover, a significant increase in proliferation rate and number of lipid droplets for pre-adipocytes was also observed in VDD offspring group. DNA methylation profiling showed that compared to CTL group, 608 promoters and 204 CpG islands were differentially methylated in the VDD group, involving 305 genes. When combined with the results of RNA-seq, 141 genes of the methylated genes were differentially expressed. In conclusion, vitamin D deficiency during pregnancy may promote the proliferation and differentiation of pre-adipocytes, which may be associated with methylation alterations of genes, ultimately leading to offspring obesity.

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“…In young adults, the dietary plus supplemental vitamin D intake was inversely related to the development of incident metabolic syndrome over 20 years of follow-up [2]. Vitamin D deficiency is common in children in West Virginia and is associated with increasing age and obesity [3]. Vitamin D deficiency is an independent risk factor for obesity and abdominal obesity in women [4].…”

Section: Introductionmentioning

confidence: 99%

The beneficial role of vitamin D in obesity: possible genetic and cell signaling mechanisms

Lương

Nguyễn

2013

Nutr J

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The prevalence rates of overweight and obesity are considered an important public issue in the United States, and both of these conditions are increasing among both children and adults. There is evidence of aberrations in the vitamin D-endocrine system in obese subjects. Vitamin D deficiency is highly prevalent in patients with obesity, and many studies have demonstrated the significant effect of calcitriol on adipocytes. Genetic studies have provided an opportunity to determine which proteins link vitamin D to obesity pathology, including the vitamin D receptor, toll-like receptors, the renin-angiotensin system, apolipoprotein E, vascular endothelial growth factor, and poly (ADP-ribose) polymerase-1. Vitamin D also exerts its effect on obesity through cell-signaling mechanisms, including matrix metalloproteinases, mitogen-activated protein kinase pathways, the reduced form of nicotinamide adenine dinucleotide phosphate, prostaglandins, reactive oxygen species, and nitric oxide synthase.In conclusion, vitamin D may have a role in obesity. The best form of vitamin D for use in the obese individuals is calcitriol because it is the active form of the vitamin D3 metabolite, its receptors are present in adipocytes, and modulates inflammatory cytokine expression.

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Occurrence of Vitamin D Deficiency in Pediatric Patients at High Risk in West Virginia

Abstract: Vitamin D deficiency is common in children in West Virginia and is associated with increasing age and obesity. Vitamin D screening and supplementation should be considered in all children with chronic illness, particularly those who are overweight.

Cited by 13 publications

References 15 publications

Vitamin D Deficiency Is Associated with Pulmonary Exacerbations in Children with Cystic Fibrosis

Vitamin D Deficiency Is Associated with Pulmonary Exacerbations in Children with Cystic Fibrosis

The effect of maternal vitamin D deficiency during pregnancy on body fat and adipogenesis in rat offspring

The beneficial role of vitamin D in obesity: possible genetic and cell signaling mechanisms

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