Occurrence, transformation, and toxicity of fumonisins and their covert products during food processing

Yang, Diaodiao; Ye, Yongli; Sun, Jiadi; Wang, Jiasheng; Huang, Chao; Sun, Xiulan

doi:10.1080/10408398.2022.2134290

Cited by 7 publications

(11 citation statements)

References 110 publications

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“…Fumonisins could combine with glucose and proteins during food processing to produce associated covert toxins . Several studies have demonstrated that glucose significantly affected the reduction of fumonisins during pressurization, which is consistent with our experimental results. , …”

Section: Resultssupporting

confidence: 92%

“…The addition of glucose during baking was found to accelerate the changes in HFBs in corn crisps, and the contents of these HFBs in corn crisps with added glucose were lower than those without added glucose. Fumonisins’ form during processing can change depending on the processing conditions, and in the food matrix, fumonisins can react with food components to form covert products such as NCM FBs or NDF FBs. ,, …”

Section: Resultsmentioning

confidence: 99%

“…Previous studies have confirmed that the presence of glucose in the matrix can lead to changes in FB1 levels, with the formation of NCM FB1 and NDF FB1. 3,31 The mass spectral information on NCM FB1 and NDF FB1 prepared in the Synthesis of NCM FB1 and NDF FB1 section was depicted in Figure 5, which was used to identify the ion pairs for analysis. After optimization using UPLC−TQD MS, NCM FB1 and NDF FB1 were analyzed in samples using the relevant ion pairs (Table S1).…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

“…Fumonisins are one of the various types of mycotoxins commonly found in corn and corn products, produced by fungi of Fusarium verticillioides and Fusarium proliferatum . In recent years, the contamination of fumonisins in cereals has been increasing, and this is a cause for great concern. , For instance, study of the levels of fumonisins in cereal and poultry feed collected in Croatia over 15 years found that most samples contained about 1 mg/kg fumonisins, while the maximum value was a staggering 22.23 mg/kg . Moreover, fumonisins have been also detected in other foods, such as milk, asparagus, and raisins, emphasizing the widespread impact of these toxic substances on our food supply. , …”

Section: Introductionmentioning

confidence: 99%

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Effect of Baking Conditions and Glucose Addition on the Changes and Transformations between Fumonisins and their Covert Forms during Corn Crisp Processing

Yang

et al. 2023

J. Agric. Food Chem.

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This study investigated the impact of baking factors on fumonisin B (FB) levels in corn crisps using ultraperformance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS). The results indicated that both free and total FBs decreased with an increase in baking time and temperature, while glucose addition facilitated this reduction. Total FBs reached the lowest value of 109.69 ng/g after 50 min of baking. Conversely, covert FBs increased with baking time but decreased with glucose addition at high temperatures. Additionally, the highest levels of hydrolyzed FBs (HFBs), N-(carboxymethyl) FB1, and N-(deoxy-d-fructos-1-yl) FB1 occurred 20 min before decomposing and were detected in corn crisps baked at 160 °C. Glucose addition accelerated the transformation between free and covert FBs. Furthermore, the inhibition of NCM FB1 accumulation was accompanied by the promotion of NDF FB1 accumulation during corn crisp processing. These findings provide insights into the effect of baking factors on FBs and suggest strategies for reducing FB contamination in corn crisps.

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Section: Resultssupporting

confidence: 92%

Section: Resultsmentioning

confidence: 99%

Section: ■ Materials and Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of Baking Conditions and Glucose Addition on the Changes and Transformations between Fumonisins and their Covert Forms during Corn Crisp Processing

Yang

et al. 2023

J. Agric. Food Chem.

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“…Fumonisins are water soluble and polar, enabling partial urinary excretion (Yang et al, 2022) in monkeys (Shephard et al, 1994), meanwhile providing dose dependent urinary excretion in rats (Cai et al, 2007). From a nephrotoxic viewpoint, it's not the relatively low urinary excretion rate is critical (Norred et al, 1993), but the biochemical route/mode of action of FB 1 .…”

Section: Novel Nephrotoxicity Biomarkers Analyzed In Animalsmentioning

confidence: 99%

New perspectives in application of kidney biomarkers in mycotoxin induced nephrotoxicity, with a particular focus on domestic pigs

et al. 2023

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The gradual spread of Aspergilli worldwide is adding to the global shortage of food and is affecting its safe consumption. Aspergillus-derived mycotoxins, including aflatoxins and ochratoxin A, and fumonisins (members of the fusariotoxin group) can cause pathological damage to vital organs, including the kidney or liver. Although the kidney functions as the major excretory system in mammals, monitoring and screening for mycotoxin induced nephrotoxicity is only now a developmental area in the field of livestock feed toxicology. Currently the assessment of individual exposure to mycotoxins in man and animals is usually based on the analysis of toxin and/or metabolite contamination in the blood or urine. However, this requires selective and sensitive analytical methods (e.g., HPLC-MS/MS), which are time consuming and expensive. The toxicokinetic of mycotoxin metabolites is becoming better understood. Several kidney biomarkers are used successfully in drug development, however cost-efficient, and reliable kidney biomarkers are urgently needed for monitoring farm animals for early signs of kidney disease. β2-microglobulin (β2-MG) and N-acetyl-β-D-glucosaminidase (NAG) are the dominant biomarkers employed routinely in environmental toxicology research, while kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) are also emerging as effective markers to identify mycotoxin induced nephropathy. Pigs are exposed to mycotoxins due to their cereal-based diet and are particularly susceptible to Aspergillus mycotoxins. In addition to commonly used diagnostic markers for nephrotoxicity including plasma creatinine, NAG, KIM-1 and NGAL can be used in pigs. In this review, the currently available techniques are summarized, which are used for screening mycotoxin induced nephrotoxicity in farm animals. Possible approaches are considered, which could be used to detect mycotoxin induced nephropathy.

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Dietary risk assessment for fumonisins: challenges and prospects

Andrade

2023

Current Opinion in Food Science

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Occurrence, transformation, and toxicity of fumonisins and their covert products during food processing

Cited by 7 publications

References 110 publications

Effect of Baking Conditions and Glucose Addition on the Changes and Transformations between Fumonisins and their Covert Forms during Corn Crisp Processing

Effect of Baking Conditions and Glucose Addition on the Changes and Transformations between Fumonisins and their Covert Forms during Corn Crisp Processing

New perspectives in application of kidney biomarkers in mycotoxin induced nephrotoxicity, with a particular focus on domestic pigs

Dietary risk assessment for fumonisins: challenges and prospects

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