Occurrence, transformation, bioaccumulation, risk and analysis of pharmaceutical and personal care products from wastewater: a review

Anand, Uttpal; Adelodun, Bashir; Cabreros, Carlo; Kumar, Pankaj; Suresh, S.; Dey, Abhijit; Ballesteros, Florencio; Bontempi, Elza

doi:10.1007/s10311-022-01498-7

Cited by 80 publications

(39 citation statements)

References 211 publications

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“…In turn, data on pharmaceuticals and their metabolites are comparatively scarce, even though they are some of the most important emerging pollutants, not only due to the growing use and diversity of compounds but also because their removal from wastewater tends to be inefficient [67]. Still, an interesting case is that of the 'conjugated oestrogen therapy' for menopause, a mixture of synthetic hormones that has been linked to breast cancer.…”

Section: Novel and 'Emerging' Pollutantsmentioning

confidence: 99%

After a Century of Research into Environmental Mutagens and Carcinogens, Where Do We Stand?

Vitorino

Costa

2023

IJERPH

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Cancer is one of the longest-known human diseases, yet only in recent times have we begun to perceive that the percentage of neoplasms caused by environmental factors, lifestyle and chemicals, is likely underestimated. The first medical reports associating cancer with pollutants like tars appeared by the early 20th century, but despite initial evidence relating oncogenesis and chromosomal alterations, only after the structure of DNA had been elucidated in the 1950s have genetic disorders been fully perceived as cause. This led to a growing interest in genotoxic and mutagenic pollutants. Even though we are now familiar with a range of environmental carcinogens spanning between aromatic hydrocarbons and asbestos to radionuclides and forms of carbon nanomaterials, establishing causal networks between pollutants and cancer remains cumbersome. In most part, this is due to the complexity of toxicant matrices, unknown modes-of-action of chemicals or their mixtures, the widening array of novel pollutants plus difficulties in subtracting background effects from true aetiology of disease. Recent advances in analytical chemistry, high-throughput toxicology, next-generation sequencing, computational biology and databases that allocate whole normal and cancer genomes, all indicate that we are on the verge of a new age of research into mechanistic ‘oncotoxicology’, but how can it impact risk assessment and prevention?

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Section: Novel and 'Emerging' Pollutantsmentioning

confidence: 99%

After a Century of Research into Environmental Mutagens and Carcinogens, Where Do We Stand?

Vitorino

Costa

2023

IJERPH

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“…At the same time, it should be noted that the COVID-19 pandemic resulted in an increase in the consumption of certain drugs, including antibiotics, and thus an increase in their amounts in the sewage stream [ 123 ]. Due to the lack of drugs that were dedicated to the fight against the SARS-CoV-2 virus, drugs from various therapeutic groups were tested, i.e., antiviral drugs used in AIDS, antimalarial drugs (e.g., chloroquine and hydroxychloroquine), antibiotics (e.g., azithromycin), painkillers and combinations of these drugs (e.g., hydroxychloroquine and azithromycin) [ 124 ].…”

Section: Environmental Impacts Of Improper Disposal Of Unused/expired...mentioning

confidence: 99%

Household Pharmaceutical Waste Disposal as a Global Problem—A Review

Rogowska

Zimmermann

2022

IJERPH

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The negative effect of the pharmaceuticals presence (persistence?) in various components of the environment is a global problem today. These compounds are released into the environment as a result of, inter alia, their use and improper disposal. Therefore, it is important to reduce excessive drug consumption and to develop a system for the collection of unused/expired pharmaceuticals. The effectiveness of actions in this area is inextricably linked with the need to educate society on how to deal properly with unwanted medications. The aim of the study was to show that the inappropriate handling of unused/expired drugs by society is an important problem in waste management systems, and it impacts the state of the environment. Forty-eight scientific articles published between 2012 and 2021 were taken into account that discussed the systems in various countries for the collection of unused/expired pharmaceuticals. This literature review shows that the main method of disposing of unused/expired medications, according to respondents from different countries, is either by disposing of them in household waste or flushing them into the sewage system. This is also the case in countries with systems or programs for the return of redundant drugs, which indicates that these systems are not sufficiently effective. This may be influenced by many factors, including the lack or ineffective education of the society.

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“…The data from 76 countries showed that the total global antibiotic consumption increased from 21.1 to 34.8 billion defined daily doses between 2000 and 2015 [2]. Studies have shown that antibiotics are detected in surface water [3,4], groundwater [5,6], domestic sewage [5,7,8], sediment [6,9,10], soil [11,12], and even drinking water [13,14] indicating that the environmental antibiotic pollution is widespread. In addition, the concentrations of antibiotics in Asian developing countries tend to be higher than those generally reported in European and North American countries [15].…”

Section: Introductionmentioning

confidence: 99%

Occurrence, fate, and risk assessment of antibiotics in typical pharmaceutical manufactories and receiving water bodies from different regions

Liu

Cai

et al. 2023

PLoS ONE

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This study aimed to investigate the presence and persistence of antibiotics in wastewater of four typical pharmaceutical manufactories in China and receiving water bodies and suggest the removal of antibiotics by the wastewater treatment process. It also evaluated the environmental impact of antibiotic residues through wastewater discharge into receiving water bodies. The results indicated that thirteen antibiotics were detected in wastewater samples with concentrations ranging from 57.03 to 726.79 ng/L. Fluoroquinolones and macrolides were the most abundant antibiotic classes found in wastewater samples, accounting for 42.5% and 38.7% of total antibiotic concentrations, respectively, followed by sulfonamides (16.4%) and tetracyclines (2.4%). Erythromycin-H2O, lincomycin, ofloxacin, and trimethoprim were the most frequently detected antibiotics; among these antibiotics, the concentration of ofloxacin was the highest in most wastewater samples. No significant difference was found in different treatment processes used to remove antibiotics in wastewater samples. More than 50% of antibiotics were not completely removed with a removal efficiency of less than 70%. The concentration of detected antibiotics in the receiving water bodies was an order of magnitude lower than that in the wastewater sample due to dilution. An environmental risk assessment showed that lincomycin and ofloxacin could pose a high risk at the concentrations detected in effluents and a medium risk in their receiving water bodies, highlighting a potential hazard to the health of the aquatic ecosystem. Overall, The investigation was aimed to determine and monitor the concentration of selected antibiotics in 4 typical PMFs and their receiving water bodies, and to study the removal of these substances in PMFs. This study will provide significant data and findings for future studies on antibiotics-related pollution control and management in water bodies.

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Occurrence, transformation, bioaccumulation, risk and analysis of pharmaceutical and personal care products from wastewater: a review

Cited by 80 publications

References 211 publications

After a Century of Research into Environmental Mutagens and Carcinogens, Where Do We Stand?

After a Century of Research into Environmental Mutagens and Carcinogens, Where Do We Stand?

Household Pharmaceutical Waste Disposal as a Global Problem—A Review

Occurrence, fate, and risk assessment of antibiotics in typical pharmaceutical manufactories and receiving water bodies from different regions

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