Occurrences of thrombocytopenia with valproic acid used for psychiatric indication

Sahu, Jharna; Hishikar, Rajesh; Sahu, Manoj Kumar; Raut, Presenjit; Bharti, Augustin Kumar; Agrawal, Swati

doi:10.18203/2319-2003.ijbcp20150388

Cited by 2 publications

(2 citation statements)

References 22 publications

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“…In a study by Jharna Sahu et al, out of 72 patients on VPA, total percentage of thrombocytopenia was found to be 12.5%; among that females constituted 19.04% and males constituted 9.8% [16] . Even in our study out of a total of 14 patients presenting with thrombocytopenia, 10 (71.4%) cases were females.…”

Section: Discussionmentioning

confidence: 93%

Hematological changes in adult patients on valproic acid therapy

Hv¹,

Tg²,

Dp³

et al. 2019

Int. J. Clin. Diagn. Pathol.

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Introduction: Valproic acid (VPA) is one of the commonly used anti-epileptic drugs. It is also an effective mood stabilizing drug. Despite its therapeutic benefits, hematological toxicity of valproic acid is increasingly encountered. Therefore, this study was carried out to evaluate the various hematological changes in adult patients on VPA and to closely monitor them so as to prevent the life threatening side effects of VPA. Aims and Objectives:(1) To study the spectrum of hematological changes in adult patients on VPA therapy and its distribution in different age groups and sex. (2) To establish a correlation between the dosage and duration of VPA therapy and its hematological effects. Materials and Methods: The present study was a prospective study done over a period of one year. A total of 50 adult patients on VPA therapy for atleast six months duration and attending the out -patient department (OPD) in General hospitals under the Bangalore rural district were included in the study. Results: A total of 50 adult patients on VPA therapy were included in the study. The patients were categorized into different age groups and sex. Female to male ratio was 2.6:1. Females constituted 72% of the total number of cases. The majority of the patients were in the age group of 26-35 years constituting 36% of the total number of cases. The spectrum of hematological changes were isolated anemia (8%), isolated leucopenia (4%), isolated thrombocytopenia (28%), bicytopenia (28%) and pancytopenia (24%). A direct correlation was established between the dosage as well as the duration of VPA therapy and the hematological changes observed especially in the elderly females. A significant negative correlation was found between the dosage of VPA therapy and the platelet and leucocyte counts. Conclusion:The study helps in identifying the potential risk factors, closely monitoring the patients on VPA and preventing life-threatening side effects. It also helps the clinicians in dose adjustments and sensitizes them to be cautious while prescribing VPA in higher doses and for longer duration.

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Section: Discussionmentioning

confidence: 93%

Hematological changes in adult patients on valproic acid therapy

Hv¹,

Tg²,

Dp³

et al. 2019

Int. J. Clin. Diagn. Pathol.

View full text Add to dashboard Cite

show abstract

“…11,14 Sahu et al, also showed that total percentage of thrombocytopenia was found to be 12.5% in epileptic children taking valproic acid. 15 Delgado et al, found that 21% epileptic children taking valproate developed thrombocytopenia. Thus, the medication can be safely lowered in most patients with thrombocytopenia rather than discontinued altogether.…”

Section: Discussionmentioning

confidence: 99%

Frequency of valproic acid induced thrombocytopenia in epileptic patients in Tertiary Care Hospital, Faisalabad.

Kanwal

Hassan

Anjum³

et al. 2020

TPMJ

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Epilepsy may be defined as recurrent abnormal neuronal discharge leading to seizures or periods of unusual behavior, sensations and sometimes loss of awareness. Valproic acid is a widely-used first-generation antiepileptic drug. It has good efficacy and pharmacoeconomic profiles. But adverse drug reactions are also reported. Thrombocytopenia is one of the adverse effects of valproic acid treatment. But local evidence was lacking. So we conducted this study to get local evidence. Objectives: To see the frequency of thrombocytopenia in epileptic patients taking valproic acid. Study Design: Descriptive cross sectional. Setting: Pediatric Department of DHQ Hospital Faisalabad. Period: 19-06-2017 to 19-12-2017. Material & Methods: 75 children were included. Then after taking informed consent patient’s blood sample was taken for complete blood count in standard vials and was sent to DHQ hospital pathology laboratory to diagnose thrombocytopenia as a count less than 150000cmm, where reports were verified by pathologist. All the data was analyzed by using SPSS version 20. Results: In this study, the mean age of patients was 6.59±3.15 years. There were 43 (57.3%) males and 32 (42.7%) females. In this study, 34 (45.3%) children had generalized type of epilepsy while 41 (54.7%) had focal type of epilepsy. The mean duration of valproic acid treatment was 3.15±2.82 years. The mean dose of valproic acid treatment was 38.40±6.07mg/kg. The mean platelet count 199602.87±58058.85mg/dl and 18 (24%) had thrombocytopenia while 57 (76%) did not develop thrombocytopenia. Conclusion: Thus the frequency of thrombocytopenia is low but still we will advise the patients to screen out themselves for bleeding or bruising.

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Occurrences of thrombocytopenia with valproic acid used for psychiatric indication

Cited by 2 publications

References 22 publications

Hematological changes in adult patients on valproic acid therapy

Hematological changes in adult patients on valproic acid therapy

Frequency of valproic acid induced thrombocytopenia in epileptic patients in Tertiary Care Hospital, Faisalabad.

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