Ochnaflavone, a Naturally Occuring Biflavonoid: Pharmacology and Prospects for Future Research

Abstract

Aims: To profile and address matters surrounding ochnaflavone (1), derivatives and analogues. Methodology: Papers concerning ochnaflavone, derivatives and analogues were accessed from search engines such as google scholar and pubmed. Results: Ochnaflavone and derivatives are compounds bearing ether linkage between the two Brings of the two flavonoid moieties. These compounds are known to possess potent biological activities such as anti-inflammatory, anticancer, anti HIV and antimicrobial. Conclusion:In this paper, an overview summary of ochnaflavone, derivatives and analogues from past to present is presented. Thus, the paper provides a sense of focus to researchers; seal breaks the unattended matters, and therefore, spearheads new research areas concerning these compounds.

Advances in resources, biosynthesis pathway, bioavailability, bioactivity, and pharmacology of ochnaflavone

“…The evidence has showed OC from Ochna serrulate inhibited the growth of UACC62 (melanoma) at TGI (Total Growth Inhibition concentration) 12.91 μM (Ndoile, 2018).…”

“…The toxicity of OC is also a property that cannot be ignored in future bioactivity studies. The evidence has showed OC from Ochna serrulate inhibited the growth of UACC62 (melanoma) at TGI (Total Growth Inhibition concentration) 12.91 μM (Ndoile, 2018).…”

“…The most rarely observed biflavonoids from nature are the ones with a linkage between the two B‐rings (BB biflavonoids) (Gontijo et al., 2017; Menezes & Diederich, 2021). Ochnaflavone (OC) and its derivatives are typical biflavonoids, where flavone–flavone, flavone–flavanone, or flavanone–flavanone units are linked in a C‐O‐C manner (Ndoile, 2018).…”

“…Since then, OC has also been found in various plant species, particularly in the Ochnaceae family, such as the genus Ochna (Williams & Harborne, 1989). It acts through intricate mechanisms by targeting enzymes, receptors, and transcription factors, modulating cellular signaling pathways associated with oxidative stress, inflammation, and tumor progression (Ndoile, 2018). In the pharmaceutical industry, OC holds promise as a lead compound for developing drugs against oxidative stress-related diseases, inflammation, and cancer.…”