Ochratoxin A-induced serum biochemical alterations in New Zealand white rabbits (Oryctolagus cuniculus)

Mir, Masood Saleem; Dwivedi, P.

doi:10.3906/vet-0901-23

Cited by 2 publications

(3 citation statements)

References 20 publications

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“…Mir and Dwivedi (2010) and El-Deep et al (2020) assessed the effects of OTA in feed of weaned rabbits. Mir and Dwivedi (2010) studied the effects of high OTA concentrations ((1 or 2 mg/kg feed for 56 days) on serum biochemical parameters. Total protein and albumin as well as chloride concentration were decreased while creatine and urea concentration were increased, in exposed rabbits compared to control animals.…”

Section: Rabbitsmentioning

confidence: 99%

“…Focal thickening of the glomerular basement membrane and degeneration of endothelial cells were the prominent alterations in the glomeruli in OTA-treated animals. Mir and Dwivedi (2010) and El-Deep et al (2020) assessed the effects of OTA in feed of weaned rabbits. Mir and Dwivedi (2010) studied the effects of high OTA concentrations ((1 or 2 mg/kg feed for 56 days) on serum biochemical parameters.…”

Section: Rabbitsmentioning

confidence: 99%

“…Mir and Dwivedi ( 2010 ) and El‐Deep et al. ( 2020 ) assessed the effects of OTA in feed of weaned rabbits.…”

Section: Assessmentmentioning

confidence: 99%

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Risks for animal health related to the presence of ochratoxin A (OTA) in feed

Schrenk,

Bignami,

Bodin

et al. 2023

EFS2

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In 2004, the EFSA Panel on Contaminants in the Food Chain (CONTAM) adopted a Scientific Opinion on the risks to animal health and transfer from feed to food of animal origin related to the presence of ochratoxin A (OTA) in feed. The European Commission requested EFSA to assess newly available scientific information and to update the 2004 Scientific Opinion. OTA is produced by several fungi of the genera Aspergillus and Penicillium. In most animal species it is rapidly and extensively absorbed in the gastro-intestinal tract, binds strongly to plasma albumins and is mainly detoxified to ochratoxin alpha (OTalpha) by ruminal microbiota. In pigs, OTA has been found mainly in liver and kidney. Transfer of OTA from feed to milk in ruminants and donkeys as well as to eggs from poultry is confirmed but low. Overall, OTA impairs function and structure of kidneys and liver, causes immunosuppression and affects the zootechnical performance (e.g. body weight gain, feed/gain ratio, etc.), with monogastric species being more susceptible than ruminants because of limited detoxification to OTalpha. The CONTAM Panel considered as reference point (RP) for adverse animal health effects: for pigs and rabbits 0.01 mg OTA/kg feed, for chickens for fattening and hens 0.03 mg OTA/kg feed. A total of 9,184 analytical results on OTA in feed, expressed in dry matter, were available. Dietary exposure was assessed using different scenarios based on either model diets or compound feed (complete feed or complementary feed plus forage). Risk characterisation was made for the animals for which an RP could be identified. The CONTAM Panel considers that the risk related to OTA in feed for adverse health effects for pigs, chickens for fattening, hens and rabbits is low.

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Section: Rabbitsmentioning

confidence: 99%

Section: Rabbitsmentioning

confidence: 99%

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Risks for animal health related to the presence of ochratoxin A (OTA) in feed

Schrenk,

Bignami,

Bodin

et al. 2023

EFS2

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Mycotoxins in grains and feed - contamination and toxic effect in animals

Pleadin

2015

Bio Anim Husb

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Mycotoxins are secondary metabolites of moulds that represent a significant food safety issue and pose a risk to health and wellbeing of humans and animals, having a negative impact on economies all over the world. They can cause intoxication in animals and affect the less productive performance and nutritional value of animal feed. Also, mycotoxins may contaminate different types of food through directly and indirectly way and cause negative health effects in humans. To estimate the potential of their harmful effect it is necessary to know the terms of mycotoxins occurrence and frequency, toxicity and biotransformation in different animal species and humans, possibility of contamination prevention, and their inactivation or reduction in the case when the incidence is inevitable. The relatively small number of comparable data on the incidence of mycotoxins in feed from European countries show the necessity of systematic control and the application of validated analytical methods in their determination. This paper gives the overview of incidence of grains and feed contamination with most important and common mycotoxins and the evidenced toxic effects in animals.

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Ochratoxin A-induced serum biochemical alterations in New Zealand white rabbits (Oryctolagus cuniculus)

Cited by 2 publications

References 20 publications

Risks for animal health related to the presence of ochratoxin A (OTA) in feed

Risks for animal health related to the presence of ochratoxin A (OTA) in feed

Mycotoxins in grains and feed - contamination and toxic effect in animals

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