Ocimum sanctum: Role in Diseases Management Through Modulating Various Biological Activity

Abstract

Tulsi has been found to be a chief source of many biologically active compounds like Ursolic acid, Eugenol, Rosmarinic acid, Linalool, Carvacrol, and ABSTRACT Medicinal plants are used commonly by traditional medical practitioners in their daily practice for the treatment of various diseases. The treatment based on natural products are preferred because they are more economic and have lesser side-effects. In this regards, Ocimum sanctum commonly known as holy basil or tulsi is used in the diseases cure and treatment since ancient time. Ocimum sanctum has been proven health promoting effect through modulation of various biological activates. Ocimum sanctum shows therapeutic role through its anti-oxidant, anti-inflammatory, anti-microbial, anti-diabetic, hepatoprotective and wound healing effects. Besides, the constituents of holy basil have been confirmed to have a noteworthy effect in cancer management through inhibition of cancer development and progression. Further, the synergistic effect of Ocimum sanctum component with anti-cancer drugs has been proven as it reduces the growth of cancer. Molecular mechanism and human clinical trials based should be performed to avail its role in diseases cure and management. This review comprehensively summarizes the role of holy basil in disease management through in vivo and in vitro study.

Effects of sodium fluoride and Ocimum sanctum extract on the lifespan and climbing ability of Drosophila melanogaster

“…Aqueous extract of the O. sanctum leaves may function simply by quenching the free radicals generated during oxidative stress or may improve the antioxidant enzyme status of the tissue in the face of the oxidative stress (Mitra et al, 2014). Tulsi has been found to be a chief source of many biologically active compounds like ursolic acid, eugenol, rosmarinic acid, linalool, carvacrol and β caryophyllene and these compounds play a significant role in the treatment and prevention of many diseases (Almatroodi, Alsahli, Almatroudi, & Rahmani, 2020). The antioxidant nature of O. sanctum leaf extract might have reduced the oxidative stress caused by NaF in D. melanogaster used in this study.…”

Efikasi Pemberian Maserasi Kemangi sebagai Antifertilitas terhadap Profil Hematologi dan Biokimia Darah Tikus Betina

“…Kemangi merupakan salah satu tanaman berkhasiat Indonesia yang banyak mengandung komponen metabolit sekunder aktif dan kegunaannya berkaitan erat dengan aktivitas seksual (Wicaksono et al, 2013). Kemangi juga diketahui memiliki khasiat sebagai antioksidan, antikanker, radioprotektif, antihipertensi dan kardioprotekrif, antimikroba, imunomodulator, hepatoprotektor, dan antifertilitas (Almatroodi et al, 2020;Ponnusam et al, 2015;Baruah & Kma, 2019). Kemangi memiliki aroma yang khas karena mengandung minyak atsiri (sineol, eugenol, linalool, timol), karvakrol, asam ursolat, asam askorbat, kampene, betakarotin, terpineol, aldehid, alkaloid, dan flavonoid (Vinnata et al, 2018;Verma, 2016).…”

“…Penelitian Navin et al (2013 menunjukkan bahwa ekstrak minyak esensial kemangi dapat bertindak sebagai antibakteri dan antiinflamasi yang signifikan. Ekstrak metanol dan air dari kemangi dapat menghambat inflamasi akut yang ditimbulkan dari pemberian karagenan (Almatroodi et al, 2020). Ekstrak kemangi mengandung senyawa fenol yang berfungsi sebagai antioksidan dan mampu meningkatkan jumlah leukosit menurut El-Shafei et al, (2021).…”

Tulsi (Ocimum sanctum): A Potent Adaptogen

“…Kelm et al [20] reported that compounds isolated from O. sanctum L. extract, Civsilineol, Civsimavatine, Isothymonin, Apigenin, Rosavinic acid and Eugenol were observed for their anti-inflammatory activity. A methanolic extract and an aqueous moratorium of O. sanctum L. reluctant acute as well as chronic inflammation in rats as tested by carrageenininduced pedal edema and craton oil -induced granuloma and exudates, respectively [21].…”