Ocimum Species: A Longevity Elixir

Pant, A.K.; Pandey, Rakesh

doi:10.1007/978-3-319-97430-9_2

Cited by 3 publications

(3 citation statements)

References 59 publications

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“…In addition to their inhibitory potential to ageing enzymes, and moisture loss prevention, oleic acid showed asignificant antioxidant behaviour [ 16 ]. It is noteworthy to highlight that β -caryophyllene, the major constituent in the oil, has previously showed a significant anti-ageing potential in C. elegans models evidenced by increasing the longevity in its lifespan by more than 22% and was found to be attributed to its antioxidant activity where it reduced the levels of the free radicals level [ 17 ]. Thus, the oil exhibited anti-ageing potential may be attributed to the synergistic action of all metabolites as each may act with a different mechanism.…”

Section: Resultsmentioning

confidence: 99%

Premna odorata: Seasonal Metabolic Variation in the Essential Oil Composition of Its Leaf and Verification of Its Anti-Ageing Potential via In Vitro Assays and Molecular Modelling

2020

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The metabolic variation in the essential oil composition of Premna odorata leaves obtained from different seasons was quantitatively and qualitatively determined employing GC/MS (Gas Chromatography coupled with Mass Spectrometry) and GC/FID (Gas chromatography equipped with flame ionization detector) techniques. It displayed the existence of 97 constituents accounting for 94.19%, 92.27%, 91.95% and 92.63% for POS (spring), POM (summer), POA (autumn) and POW (winter) whole essential oils. β-Caryophyllene constituting the main metabolite in the oil in the different seasons. To better visualize the differences between them, GC data were exposed to chemometric analysis. A PCA (principal component analysis) score plot revealed the closeness of POS and POW. Molecular modelling on collagenase, elastase and hyaluronidase enzymes active centres shows that different compounds existing in the essential oil of Premna odorata leaves shows binding to the active sites with variable degrees that suggested its anti-ageing potential. Palmitic acid displayed the highest fitting for both the collagenase and elastase active centres in both pH-based and rule-based ionization methods with ∆G equals −78.27 and −44.77 kcal/mol, respectively; meanwhile, heptacosane showed the highest fitting score in the hyaluronidase centre with ∆G = −43.78 kcal/mol. In vitro assays consolidates the obtained modelling studies in which essential oil shows considerable anti-elastase and anti-hyaluronidase potential as evidenced by their IC50 values being 49.3 and 37.7 μg/mL, respectively; meanwhile, the essential oil of Premna odorata leaves displayed mild anti-collagenase potential. Thus, it can be concluded that Premna odorata could serve as a promising anti-ageing naturally occurring drug that could be effectively incorporated by pharmaceutical industries in cosmetics combating ageing and skin wrinkling.

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Section: Resultsmentioning

confidence: 99%

Premna odorata: Seasonal Metabolic Variation in the Essential Oil Composition of Its Leaf and Verification of Its Anti-Ageing Potential via In Vitro Assays and Molecular Modelling

2020

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“…En la medicina tradicional mexicana, el conocimiento popular sobre las plantas medicinales ha dado, a lo largo del tiempo, un gran número de especies que han sido y siguen siendo utilizadas en el tratamiento de problemas médicos frecuentes en el país, tales como: enfermedades infecciosas, gastrointestinales, pulmonares, metabólicas, cardiovasculares, etcétera [13,88]. En el caso de la hipertensión y de las complicaciones que se presentan a largo plazo asociadas a ésta, existen estudios de una gran variedad de especies vegetales que muestran su capacidad para modificar los eventos de daño en modelos biológicos [87,89].…”

Section: Ocimumunclassified

“…Los ácidos fenólicos tienen efecto antioxidante y, por lo tanto, un potente papel neuroprotector [94]. Por otro lado, los componentes activos como el ácido ursólico, el ácido rosmarínico, el eugenol y el bcariofileno que se han evaluado individualmente para determinar su duración y efectos moduladores del estrés relacionados con la edad y se sugerido que poseen potencialantienvejecimiento[89]. así por la planta de la que se aisló, Rosmarinus officinalis.…”

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Efecto de Ocimum basilicum y Ocimum selloi sobre el daño vascular cerebral en un modelo de hipertensión arterial crónica

Herrera¹,

Yuritzi²

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Volatiles, phenolic compounds and bioactive properties of essential oil and aqueous extract of purple basil (Ocimum basilicum L.) and antidiabetic activity in streptozotocin-induced diabetic Wistar rats

Kanmaz,

Gokce,

Hayaloglu

2023

Food Chemistry Advances

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Ocimum Species: A Longevity Elixir

Cited by 3 publications

References 59 publications

Premna odorata: Seasonal Metabolic Variation in the Essential Oil Composition of Its Leaf and Verification of Its Anti-Ageing Potential via In Vitro Assays and Molecular Modelling

Premna odorata: Seasonal Metabolic Variation in the Essential Oil Composition of Its Leaf and Verification of Its Anti-Ageing Potential via In Vitro Assays and Molecular Modelling

Efecto de Ocimum basilicum y Ocimum selloi sobre el daño vascular cerebral en un modelo de hipertensión arterial crónica

Volatiles, phenolic compounds and bioactive properties of essential oil and aqueous extract of purple basil (Ocimum basilicum L.) and antidiabetic activity in streptozotocin-induced diabetic Wistar rats

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