Ockelbo Disease: Epidemic Arthritis-Exanthema Syndrome in Sweden Caused by Sindbis-Virus Like Agent

Skogh, M; Espmark, Åke

doi:10.1016/s0140-6736(82)91834-7

Cited by 102 publications

(50 citation statements)

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“…Genetic risk factors could play a role and for SINV it was recently shown that HLA-DRB1*01 was associated with clinically manifest SINV infection [3]. In Sweden, SINV infection in humans is called Ockelbo disease, in Finland Pogosta disease and in Russia Karelian fever [4,5]. However, reports of the disease are lacking from most other European countries.…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of Sindbis virus and associated risk factors in northern Sweden

et al. 2013

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SUMMARYMosquito-borne Sindbis virus (SINV) cause disease characterized by rash, fever and arthritis which often leads to long-lasting arthralgia. To determine the seroprevalence of SINV and associated risk factors in northern Sweden, a randomly selected population aged between 25 and 74 years were invited to join the MONICA study. Serum from 1611 samples were analysed for specific IgG antibodies. Overall, 2·9% had IgG against SINV. More men (3·7%) than women (2·0%) were SINV seropositive (P = 0·047) and it was more common in subjects with a lower educational level (P = 0·013) and living in small, rural communities (P < 0·001). Seropositivity was associated with higher waist circumference (P = 0·1), elevated diastolic blood pressure (P = 0·037), and history of a previous stroke (P = 0·011). In a multiple logistic regression analysis, adjusting for known risk factors for stroke, seropositivity for SINV was an independent predictor of having had a stroke (odds ratio 4·3, 95% confidence interval 1·4-13·0, P = 0·011).

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Section: Introductionmentioning

confidence: 99%

Seroprevalence of Sindbis virus and associated risk factors in northern Sweden

et al. 2013

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“…Human SIN virus infection was considered a minor medical problem from a public health point of view until epidemics in South Africa in 1974 (McIntosh et al, 1976) and later in areas of Northern Europe in the mid 1980s (Skogh & Espmark, 1982 ;Lvov et al, 1984), often involving hundreds of cases, were reported. SIN virus is the most commonly isolated arbovirus from mosquitoes in Australia (Mackenzie et al, 1994).…”

Section: Introductionmentioning

confidence: 99%

Geographic distribution and evolution of Sindbis virus in Australia.

Sammels

Lindsay

Poidinger

et al. 1999

Journal of General Virology

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The molecular epidemiology and evolution of Sindbis (SIN) virus in Australia was examined. Several SIN virus strains isolated from other countries were also included in the analysis. Two regions of the virus genome were sequenced including a 418 bp region of the E2 gene and a 484 bp region containing part of the junction region and the 5h end of the C gene. Analysis of the nucleotide and deduced amino acid sequence data from 40 SIN virus isolates clearly separated the Paleoarctic/ Ethiopian and Oriental/Australian genetic types of SIN virus. Examination of the Australian strains showed a temporal rather than geographic relationship. This is consistent with the virus having migratory birds as the major vertebrate host, as it allows for movement of virus over vast areas of the continent over a relatively short period of time. The results suggest that the virus is being periodically redistributed over the continent from an enzootic focus of evolving SIN virus. However, SIN virus strains isolated from mosquitoes collected in the south-west of Australia appear to represent a new SIN virus lineage, which is distinct from the Paleoarctic/Ethiopian and Oriental/Australian lineages. Given the widespread geographic dispersal of the Paleoarctic/ Ethiopian and Oriental/Australian lineages, it is surprising that the South-west genetic type is so restricted in its area of circulation. Nucleotide sequence data from the C gene of the prototype strain of the alphavirus Whataroa were also determined. This virus was found to be genetically distinct from the SIN virus isolates included in the present study ; however, it is clearly SIN-like and appears to have evolved from a SIN-like ancestral virus.

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“…Sindbis-group alphaviruses, including Ockelbo virus, Karelian fever virus, and GirdwoodS.A. virus, are associated with acute and persistent arthralgia in northern Europe and South Africa (14,26,29). Ockelbo disease, one of the best characterized of the Sindbis-group alphavirus arthralgias, is often incapacitating (10,29), and one study found that symptoms lasted for months to years in 31% of patients [(B. Niklasson and Å. Espmark, Letter, Lancet i:1039-1040, 1986).…”

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confidence: 99%

“…Sequence comparisons demonstrate that S.A.AR86 is most closely related to GirdwoodS.A. virus, which was isolated from a South African patient suffering from arthralgia (14,20,25), and Ockelbo virus, the etiologic agent of Ockelbo disease (24,26). Full-length infectious cDNA clones of S.A.AR86 are also available (25).…”

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Sindbis-Group Alphavirus Replication in Periosteum and Endosteum of Long Bones in Adult Mice

Heise

Simpson

Johnston

2000

J Virol

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Several alphaviruses, including the Sindbis-group viruses, Ross River virus, O'nyong-nyong virus, and Chikungunya virus, are associated with outbreaks of acute and persistent arthralgia and arthritis in humans. Mechanisms underlying alphavirus-induced arthralgia and arthritis are not clearly understood, though direct viral replication within or around the affected joints is thought to contribute to disease. S.A.AR86 is a Sindbis-group alphavirus closely related to the arthralgia-associated Ockelbo and GirdwoodS.A viruses. Following inoculation with S.A.AR86 derived from a molecular clone, infectious virus was isolated from bone and joint tissue 1 to 6 days postinfection. Studies using either in situ hybridization or S.A.AR86-derived double promoter viruses and replicons expressing green fluorescent protein localized sites of viral replication to the periosteum, tendons, and endosteum within the epiphyses of the long bones adjacent to articular joints. These results demonstrate that alphaviruses associated with arthralgia in humans replicate within bone-associated connective tissue adjacent to articular joints in an adult mouse model.

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Ockelbo Disease: Epidemic Arthritis-Exanthema Syndrome in Sweden Caused by Sindbis-Virus Like Agent

Cited by 102 publications

References 7 publications

Seroprevalence of Sindbis virus and associated risk factors in northern Sweden

Seroprevalence of Sindbis virus and associated risk factors in northern Sweden

Geographic distribution and evolution of Sindbis virus in Australia.

Sindbis-Group Alphavirus Replication in Periosteum and Endosteum of Long Bones in Adult Mice

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