Oct-4 Transcription Factor Is Differentially Expressed in the Mouse Embryo during Establishment of the First Two Extraembryonic Cell Lineages Involved in Implantation

Palmieri, Susan L.; Peter, W Kinyanjui; Hess, Heike; Schöler, Hans R.

doi:10.1006/dbio.1994.1312

Cited by 563 publications

(460 citation statements)

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“…Cdx2, which is related to Drosophila Caudal, is expressed in the TE of the blastocyst where it is required for promoting TE fate (Beck et al, 1995;Strumpf et al, 2005). Two ICMspecific transcription factors are Oct4, a POU domain protein, and Nanog, a homeodomain protein (Palmieri et al, 1994;Chambers et al, 2003;Mitsui et al, 2003). Interactions among these factors during blastocyst formation are thought to reinforce TE and ICM fates.…”

Section: Development Of the Te Classical Models Of Te Formationmentioning

confidence: 99%

“…One gene important for ICM development is a POU domain transcription factor, Oct4. Oct4 is initially detectable in nuclei of all cells of the early embryo, but its expression becomes restricted to the ICM upon blastocyst formation (Palmieri et al, 1994). Oct4 null embryos implant, indicating formation of a functional TE, but they soon die and lack ICM derivatives such as epiblast and yolk sac (Nichols et al, 1998).…”

Section: Maintenance Of the Icm/te Lineage Restrictionmentioning

confidence: 99%

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Cell and molecular regulation of the mouse blastocyst

Yamanaka

Ralston

Stephenson

et al. 2006

Developmental Dynamics

265

221

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Animals use diverse strategies to specify tissue lineages during development. A common strategy is to partition maternally supplied and localized lineage determinants into progenitor cells. The mouse embryo appears to use a different, more regulative strategy to specify the first three lineages: the epiblast (EPI: future embryo), the trophectoderm (TE: future placenta), and the primitive endoderm (PE: future yolk sac). These lineages are specified during two successive differentiation steps leading to formation of the blastocyst. Here, we review classic and contemporary models of early lineage specification in the mouse, and describe recent efforts to understand the molecular regulation of these events. We describe evidence that trophectoderm differentiation bears resemblance to the process of epithelialization and describe the importance of apical/basal protein complexes in regulating this process. Next, we present a revised model of PE specification, and describe evidence that PE cells in the inner cell mass sort out to occupy their ultimate position on the surface of the EPI. Finally, we describe factors that reinforce these lineages and three distinct stem cell types that can be isolated from them. Together, these mechanisms guide the differentiation of the first lineages of the mouse and thereby set up tissues that will be important for the first steps of embryonic body patterning. Developmental Dynamics 235:2301-2314, 2006.

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Section: Development Of the Te Classical Models Of Te Formationmentioning

confidence: 99%

Section: Maintenance Of the Icm/te Lineage Restrictionmentioning

confidence: 99%

Cell and molecular regulation of the mouse blastocyst

Yamanaka

Ralston

Stephenson

et al. 2006

Developmental Dynamics

265

221

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show abstract

“…Indeed, Oct4 is expressed by germ cells from the totipotent zygote to the highly specialized oocyte [9], [20], [21]. It is likely that Oct4 may function in concert with other regulators to activate specific target genes in specific cell types at defined developmental stages.…”

Section: Structure and Function Of Oct4mentioning

confidence: 99%

“…In the mouse, Oct4 mRNA is present in mature oocytes [20]. At the eightcell stage, Oct4 expression reaches a much higher level [21]. Subsequently, Oct4 expression becomes restricted to the ICM, and is downregulated in the TE and primitive endoderm (see Fig 1) [21].…”

Section: Regulation Of Oct4 Expressionmentioning

confidence: 99%

Stem cell pluripotency and transcription factor Oct4

et al. 2002

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Mammalian cell totipotency is a subject that has fascinated scientists for generations. A long lasting question whether some of the somatic cells retains totipotency was answered by the cloning of Dolly at the end of the 20th century. The dawn of the 21 st has brought forward great expectations in harnessing the power of totipotentcy in medicine. Through stem cell biology, it is possible to generate any parts of the human body by stem cell engineering. Considerable resources will be devoted to harness the untapped potentials of stem cells in the foreseeable future which may transform medicine as we know today. At the molecular level, totipotency has been linked to a singular transcription factor and its expression appears to define whether a cell should be totipotent. Named Oct4, it can activate or repress the expression of various genes. Curiously, very little is known about Oct4 beyond its ability to regulate gene expression. The mechanism by which Oct4 specifies totipotency remains entirely unresolved. In this review, we summarize the structure and function of Oct4 and address issues related to Oct4 function in maintaining totipotency or pluripotency of embryonic stem cells.

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“…It is expressed in totipotent and pluripotent cells, including oocytes, early cleavage stage embryos, the inner cell mass of the blastocyst, the epiblast layer, and germ cells (Scholer et al, 1990;Palmieri et al, 1994;Pesce and Scholer, 2000). It is also present in cultured embryonic stem cells, embryonic germ cells, and embryonal carcinoma cells (Lenardo et al, 1989;Scholer et al, 1989;Yeom et al, 1996;Brehm et al, 1998).…”

Section: Similarities Between Embryonic Stem Cells and Adult Ppelscsmentioning

confidence: 99%

Clonogenic analysis reveals reserve stem cells in postnatal mammals. II. Pluripotent epiblastic‐like stem cells

et al. 2004

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Undifferentiated cells have been identified in the prenatal blastocyst, inner cell mass, and gonadal ridges of rodents and primates, including humans. After isolation these cells express molecular and immunological markers for embryonic cells, capabilities for extended self‐renewal, and telomerase activity. When allowed to differentiate, embryonic stem cells express phenotypic markers for tissues of ectodermal, mesodermal, and endodermal origin. When implanted in vivo, undifferentiated noninduced embryonic stem cells formed teratomas. In this report we describe a cell clone isolated from postnatal rat skeletal muscle and derived by repetitive single‐cell clonogenic analysis. In the undifferentiated state it consists of very small cells having a high ratio of nucleus to cytoplasm. The clone expresses molecular and immunological markers for embryonic stem cells. It exhibits telomerase activity, which is consistent with its extended capability for self‐renewal. When induced to differentiate, it expressed phenotypic markers for tissues of ectodermal, mesodermal, and endodermal origin. The clone was designated as a postnatal pluripotent epiblastic‐like stem cell (PPELSC). The undifferentiated clone was transfected with a genomic marker and assayed for alterations in stem cell characteristics. No alterations were noted. The labeled clone, when implanted into heart after injury, incorporated into myocardial tissues undergoing repair. The labeled clone was subjected to directed lineage induction in vitro, resulting in the formation of islet‐like structures (ILSs) that secreted insulin in response to a glucose challenge. This study suggests that embryonic‐like stem cells are retained within postnatal mammals and have the potential for use in gene therapy and tissue engineering. Anat Rec Part A 277A:178–203, 2004. © 2004 Wiley‐Liss, Inc.

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Oct-4 Transcription Factor Is Differentially Expressed in the Mouse Embryo during Establishment of the First Two Extraembryonic Cell Lineages Involved in Implantation

Cited by 563 publications

References 0 publications

Cell and molecular regulation of the mouse blastocyst

Cell and molecular regulation of the mouse blastocyst

Stem cell pluripotency and transcription factor Oct4

Clonogenic analysis reveals reserve stem cells in postnatal mammals. II. Pluripotent epiblastic‐like stem cells

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