OCT and Fundus Autofluorescence Enhances Visualization of White Dot Syndromes

Abstract

This review collates current literature and provides a succinct overview of the clinical presentation of WDS using OCT and FAF.

Acute posterior multifocal placoid pigment epitheliopathy in a patient with familial Mediterranean fever

“…In our patient, APMPPE developed during an episode of FMF and clinically manifested as protracted febrile myalgia. Fundoscopy, fluorescein angiography and OCT were consistent with the diagnosis of APMPPE . The clinical course was also typical of APMPPE, which is characterised by good clinical prognosis.…”

“…Fundoscopy, fluorescein angiography and OCT were APMPPE and familial Mediterranean fever Georgakopoulos, Antonopoulos, Makri, Vasilakis, Liossis and Andonopoulos consistent with the diagnosis of APMPPE. 4,10 The clinical course was also typical of APMPPE, which is characterised by good clinical prognosis. To our knowledge, APMPPE has not been described in association with FMF.…”

Fundus Autofluorescence Findings in Eyes With Birdshot Chorioretinitis

“…FAF imaging has been used to study a variety of inflammatory eye diseases, including multifocal choroiditis and panuveitis syndrome, punctate inner choroidopathy, serpiginous choroiditis, multiple evanescent white dot syndrome, and Vogt-Koyanagi-Harada disease. [23][24][25][26][27][28][29][30][31][32][33][34][35][36][37] In many conditions, FAF imaging reveals areas of disease activity that are more widespread than would be suspected by other imaging techniques or by clinical investigation, suggesting its potential value in the clinical assessment of patients with these disorders.…”

Multi-modal imaging and anatomic classification of the white dot syndromes

“…A central clearing will be seen as they begin to resolve roughly within 2–3 months and progressively become hypopigmented. OCT exhibits hyperreflectivity of the outer retinal layers in the early stages which is thought to reflect swelling of the outer retinal cells or presence of inflammatory cell infiltrates [66, 67]. As the lesions resolve, hyperreflectivity of the outer retinal layers decreases.…”