OCT angiography in a comprehensive assessment of hypotensive therapy effectiveness in patients with primary open-angle glaucoma

Yurieva, Tatyana N; Жукова, С. И.

doi:10.21516/2072-0076-2019-12-3-43-49

Cited by 2 publications

(1 citation statement)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Появление в 2010 г. ОКТ с улучшенной глубиной визуализации позволило повысить информативность исследования и доказать, что у больных с первичной открытоугольной глаукомой (ПОУГ) наблюдается значимое снижение толщины хориоидеи по сравнению с нормой, особенно при глаукоме нормального давления [7][8][9][10][11]. Большое количество работ посвящено оценке эффективности гипотензивной терапии и измерению толщины хориоидеи после антиглаукомных операций, сопровождающихся значимым снижением ВГД [12][13][14][15]. Однако до сих пор вопросы о том, какие именно структуры вовлечены в процесс адаптации при резком перепаде ВГД, остается открытым.…”

Section: Introductionunclassified

Choroidal blood flow in glaucoma patients in conditions of ophthalmic hypertension and compensated intraocular pressure

Юрьева¹,

Жукова²,

Помкина³

2020

SSMJ

View full text Add to dashboard Cite

Purpose. To evaluate changes in chorioretinal blood flow in the early postoperative period after non-penetrating deep sclerectomy (NPDS) in patients with primary open-angle glaucoma (POAG) and determine their relationship with the level of Goldman intraocular pressure (IOPg). Material and methods. The study included 36 patients with primary open-angle glaucoma of stage 1-2, with an IOP level above 21 mm Hg at the maximum hypotensive mode. All patients underwent glaucoma surgery (NPDS) by a single surgeon. IOP measurement was performed by dynamic bidirectional applanation using the Ocular Response Analyzer (Reichert Inc., USA). When evaluating the results, the Goldman IOP indicators (IOPg) were taken into account. The ophthalmic examination included optical coherence tomography of the optic disk and macular area, as well as assessment of the blood flow of these structures using optical coherence tomography in angio mode (OCTA) (RTVue XR Avanti, Optovue Inc., США). The thickness of the choroid was estimated using crossline protocols performed through the center of the fovea in the horizontal and vertical meridians. Results. Based on the assessment of changes in the indicators of ocular blood flow in the postoperative period, all patients were divided into 2 groups: group 1-28 patients (28 eyes) who showed improvement in OCTA after surgery, group 2-8 patients (8 eyes) who, according to OCTA data, showed no changes or decreased indicators of ocular blood flow after surgery. In patients of both groups, the level of IOPg before surgical treatment was comparable. On the 3rd day after NPDS IOPg in the group 1 decreased to 9.3 ± 1.2 mm Hg, while in group 2 hypotonia was detected (IOPg 3,6 ± 1,3 mm Hg, р = 0,001). All patients showed an increase in the thickness of the choroid in the central area and peripapillary after glaucoma surgery: in group 1 by 23 and 26 %, in group 2 by 48 and 62 %, respectively. In group 2 there was a significant increase in the large vessels caliber and the vascular membrane thickness as a whole to 115.4 % of the original. In group 1 patients, against the background of normalization of ophthalmotonus, there was a tendency to increase the capillary density of the superficial vascular plexus (from 40.9 ± 5.38 to 41.1 ± 3.56 %) and the deep vascular plexus (from 43.9 ± 6.1 to 44.7 ± 5.97 %). There was a positive trend of increasing capillary density in the radial peripapillary plexus (from 46.6 ± 8.9 to 47.2 ± 9.0 %). In patients of group 2, capillary density significantly decreased: from 39.9 ± 3.64 to 37.6 ± 2.48 % in the superficial vascular plexus and from 41.1 ± 4.72 to 38.7 ± 3.51 % in the deep vascular plexus. Conclusion. A decrease in the level of ophthalmotonus after NPDS was accompanied, in most cases, by a moderate increase in the thickness of the choroid and a tendency to improve blood flow in the retinal plexuses. Postoperative hypotension is characterized by dysregulation of choroidal blood flow, decompression violation of topographic relationships, which generally leads to the formati...

show abstract

Section: Introductionunclassified

Choroidal blood flow in glaucoma patients in conditions of ophthalmic hypertension and compensated intraocular pressure

Юрьева¹,

Жукова²,

Помкина³

2020

SSMJ

View full text Add to dashboard Cite

show abstract

The relationship between different types of primary glaucoma and retinal vein occlusion

Galimova,

Kuroyedov,

Galimova

2024

Glaucoma

View full text Add to dashboard Cite

The relationship between glaucoma and retinal vein occlusion (RVO) has been a subject of ongoing scientific interest. Several population-based studies have identified glaucoma as a significant risk factor for the development of RVO. However, data on the relationship between different types of primary glaucoma and RVO remain contradictory. Clarifying the nature of this relationship and identifying its possible pathogenic basis could improve treatment approaches for these conditions.This review summarizes information on the relationship between various types of primary glaucoma and RVO, establishes the role of primary open-angle glaucoma as a risk factor for RVO development, and discusses the impact of localized hemodynamic disturbances on the development and progression of primary open-angle glaucoma. The article also notes the different ways in which primary angle-closure glaucoma can affect the development of occlusion of central retinal vein and its branches, and summarizes the information on the influence of medications used to treat macular edema in RVO on intraocular pressure. Recommendations are provided on the selection of treatment methods for macular edema associated with retinal vein occlusion, taking into account the presented data.

show abstract

OCT angiography in a comprehensive assessment of hypotensive therapy effectiveness in patients with primary open-angle glaucoma

Cited by 2 publications

References 31 publications

Choroidal blood flow in glaucoma patients in conditions of ophthalmic hypertension and compensated intraocular pressure

Choroidal blood flow in glaucoma patients in conditions of ophthalmic hypertension and compensated intraocular pressure

The relationship between different types of primary glaucoma and retinal vein occlusion

Contact Info

Product

Resources

About