OCT Biomarkers as Functional Outcome Predictors in Diabetic Macular Edema Treated with Dexamethasone Implant

Zur, Dinah; Mariussi, Miriana; Busch, Catharina; Cebeci, Zafer; Chhablani, Jay; Chaikitmongkol, Voraporn; Couturier, Aude; Fraser‐Bell, Samantha; Giancipoli, Ermete; Iglicki, Matías; Invernizzi, Alessandro; Laíns, Inês; Loewenstein, Anat; Lupidi, Marco; Rehák, Matúš; Rodriguez, Patricio; Mendes, Thais Sousa; Sala‐Puigdollers, Anna; Zur, Dinah

doi:10.1016/j.ophtha.2017.08.031

Cited by 216 publications

(217 citation statements)

References 44 publications

Supporting

Mentioning

199

Contrasting

Unclassified

Order By: Relevance

“…In conclusion, this current study confirms and adds to the report that has been published by our group previously in Ophthalmology (Zur et al. ,b). We demonstrated that certain OCT biomarkers can help to predict response to DEX implant in eyes with DME.…”

Section: Discussionsupporting

confidence: 93%

“…This novel finding adds one more biomarker to the list previously reported by our group (Zur et al. ,b). The presence of SRF, IS/OS continuity, absence of HRF and an attached vitreoretinal interface predict better visual outcome after treatment with DEX implant in eyes with DME.…”

Section: Discussionsupporting

confidence: 64%

“…The absence of DRIL was significantly associated with the presence of SRF which is known to be more commonly seen in acute DME (Zur et al. ,b). These findings might indicate DRIL as a sign of chronicity of macular oedema.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, the authors of this study identified baseline spectral‐domain (SD)‐OCT measures which can serve as biomarkers for predicting visual outcome after treatment with DEX Implant (Zur et al. ,b). Sun et al.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Disorganization of retinal inner layers as a biomarker in patients with diabetic macular oedema treated with dexamethasone implant

Zur

Iglicki

Sala‐Puigdollers

et al. 2019

Acta Ophthalmologica

Self Cite

View full text Add to dashboard Cite

Purpose To investigate disorganization of retinal inner layers (DRIL) as a biomarker in eyes with diabetic macular oedema (DME) treated by intravitreal dexamethasone (DEX) implant. Methods Multicentre, retrospective study including eyes with DME treated with DEX implant and follow‐up of 12 months after the first injection. OCT scans were evaluated for the presence of DRIL and other structural features. Best corrected visual acuity (BCVA) and central subfield thickness (CST) were recorded at baseline and at 2, 4, 6 and 12 months after treatment. Correlation between DRIL at baseline and outcomes after DEX treatment and the change in DRIL were analysed. Results A total of 177 eyes (177 patients; naïve, n = 131; refractory, n = 46) were included. Patients without DRIL at baseline gained significantly more vision and enjoyed greater reduction in CST over 12 months (both p = 0.03). DRIL at the boundary between the ganglion cell‐inner plexiform complex and inner nuclear layer improved in 48/64 eyes (75%, p < 0.001), while DRIL between the inner nuclear layer and outer plexiform layer improved in 27/77 eyes (35%, p = 0.004). Conclusions This is the first study to show that DEX implant has the potential to ameliorate DRIL. Patients without DRIL at baseline have a favourable outcome. DRIL may serve a robust biomarker in DME treated by DEX implant.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Disorganization of retinal inner layers as a biomarker in patients with diabetic macular oedema treated with dexamethasone implant

Zur

Iglicki

Sala‐Puigdollers

et al. 2019

Acta Ophthalmologica

Self Cite

View full text Add to dashboard Cite

show abstract

“…In contrast with our results, they found a better visual outcome in eyes without HRS at 4 months (Zur et al. ). However, at baseline, they found that HRS were more frequent in eyes refractory to anti‐VEGF that could be associated with a worse prognosis.…”

Section: Discussioncontrasting

confidence: 99%

Dexamethasone for unresponsive diabetic macular oedema: optical coherence tomography biomarkers

Bonfiglio

Reibaldi

Pizzo

et al. 2018

Acta Ophthalmologica

View full text Add to dashboard Cite

Purpose To analyse the effects of intravitreal dexamethasone implant (DEX) in patients with diabetic macular oedema (DME) unresponsive to ranibizumab treatment, in relation to the inflammatory optical coherence tomography (OCT) retinal features, subfoveal neuroretinal detachment (SND) and hyperreflective retinal spots (HRS). Methods Patients with DME poorly responsive to three injections of ranibizumab were treated with DEX. Best‐corrected visual acuity (BCVA) and central macula thickness (CMT, measured by Spectralis SD‐OCT) were assessed at baseline and at 1, 3, and 6 months. Results Overall, 44 eyes were included in the study. In the whole group, mean BCVA (baseline 51.5 ± 8.3 letters) increased significantly at 1 month (to 56.9 ± 8.8 letters; Tukey HSD p = 0.017) and was 55.5 ± 8.8 letters at 3 months (Tukey HSD p = 0.128). Central macula thickness (CMT) reduced significantly at 1 and 3 months (417 ± 149 μm and 469 ± 128 μm, respectively, both Tukey HSD p < 0.001 versus baseline). Subgroup analysis showed a significant BCVA increase at 1 month in eyes with SND + HRS (from 51.2 ± 9.2 to 58.2 ± 9.0, p = 0.029), and a trend to BCVA increase in eyes with HRS (from 52.3 ± 6.4 to 56.8 ± 7.9, p = 0.080), with a significant CMT decrease in both groups (p < 0.001). No changes of either parameter were found in eyes without SND and HRS. Conclusion Spectral domain OCT is useful in identifying some inflammatory features in DME. Among DME eyes ‘poorly responsive’ to ranibizumab, those with SND and HRS responded better to DEX implants than those without these features.

show abstract

Quantification of Fluid Resolution and Visual Acuity Gain in Patients With Diabetic Macular Edema Using Deep Learning

et al. 2020

View full text Add to dashboard Cite

show abstract

OCT Biomarkers as Functional Outcome Predictors in Diabetic Macular Edema Treated with Dexamethasone Implant

Cited by 216 publications

References 44 publications

Disorganization of retinal inner layers as a biomarker in patients with diabetic macular oedema treated with dexamethasone implant

Disorganization of retinal inner layers as a biomarker in patients with diabetic macular oedema treated with dexamethasone implant

Dexamethasone for unresponsive diabetic macular oedema: optical coherence tomography biomarkers

Quantification of Fluid Resolution and Visual Acuity Gain in Patients With Diabetic Macular Edema Using Deep Learning

Contact Info

Product

Resources

About