2016
DOI: 10.1016/j.devcel.2016.06.021
|View full text |Cite
|
Sign up to set email alerts
|

Oct4 Is a Key Regulator of Vertebrate Trunk Length Diversity

Abstract: Vertebrates exhibit a remarkably broad variation in trunk and tail lengths. However, the evolutionary and developmental origins of this diversity remain largely unknown. Posterior Hox genes were proposed to be major players in trunk length diversification in vertebrates, but functional studies have so far failed to support this view. Here we identify the pluripotency factor Oct4 as a key regulator of trunk length in vertebrate embryos. Maintaining high Oct4 levels in axial progenitors throughout development wa… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

2
93
1
1

Year Published

2017
2017
2020
2020

Publication Types

Select...
7
2

Relationship

1
8

Authors

Journals

citations
Cited by 71 publications
(97 citation statements)
references
References 42 publications
(88 reference statements)
2
93
1
1
Order By: Relevance
“…In addition, genes such as Epha2 , Epha5 , Pou5f1 ( Oct3/4 ) , Sema6a , and Zic5 were enriched in e-NMPs. The function of many of these genes will require further investigation because, for example, Pou5f1 ( Oct3/4 ) has recently been implicated in the maintenance of axial progenitors and trunk extension (Aires et al., 2016). …”
Section: Discussionmentioning
confidence: 99%
“…In addition, genes such as Epha2 , Epha5 , Pou5f1 ( Oct3/4 ) , Sema6a , and Zic5 were enriched in e-NMPs. The function of many of these genes will require further investigation because, for example, Pou5f1 ( Oct3/4 ) has recently been implicated in the maintenance of axial progenitors and trunk extension (Aires et al., 2016). …”
Section: Discussionmentioning
confidence: 99%
“…Despite the well-characterized role of pluripotency factors in embryonic stem cells and the preimplantation embryo (Chambers & Tomlinson, 2009), their function at later developmental stages has received much less attention, even if they are expressed up to gastrulation in mice (Yeom et al, 1996;Hart et al, 2004;Osorno et al, 2012) and primates (Nakamura et al, 2016). Oct4 is involved in proliferation of the primitive streak (DeVeale et al, 2013), in correct trunk elongation of the trunk (Aires et al, 2016), and some evidence points to it having a role in mesoderm and subsequent hematopoietic specification (Kong et al, 2009). However, no clear function is known for Nanog after implantation apart from the regulation of germline development (Chambers et al, 2007).…”
Section: Discussionmentioning
confidence: 99%
“…Mouse embryos with mutations associated to a prolonged trunk extension (Gdf11 loss of function mutants or overexpression of OCT4; Aires et al, 2016) show an abnormal increase in Fgf8 expression in the tailbud region. In the chick, RA derived from the tailbud is also important for the correct termination of FGF8 expression (Olivera-Martinez et al, 2012) while in the mouse other mechanisms seem to be responsible (Cunningham et al, 2011), as body axis extension continues for a much longer time to form the tail in mouse.…”
Section: Fgf Signaling Pathway: Expression Of Components In the Develmentioning
confidence: 99%