“…Despite the well-characterized role of pluripotency factors in embryonic stem cells and the preimplantation embryo (Chambers & Tomlinson, 2009), their function at later developmental stages has received much less attention, even if they are expressed up to gastrulation in mice (Yeom et al, 1996;Hart et al, 2004;Osorno et al, 2012) and primates (Nakamura et al, 2016). Oct4 is involved in proliferation of the primitive streak (DeVeale et al, 2013), in correct trunk elongation of the trunk (Aires et al, 2016), and some evidence points to it having a role in mesoderm and subsequent hematopoietic specification (Kong et al, 2009). However, no clear function is known for Nanog after implantation apart from the regulation of germline development (Chambers et al, 2007).…”